HitPredict

Interactor 1: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Interactor 2: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30209976, 23663784
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003723 - RNA binding GO:0010494 - cytoplasmic stress granule
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 1191
+	Hs
		516698 PABP1_HUMAN (1-644): 0: 542: 74.54		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1329984 PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1031360 PABP4_HUMAN (1-644): 0: 585: 100.00		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		516550 PABP1_HUMAN (1-644): 0: 542: 74.54		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136287 PABP3_HUMAN (1-644): 7.04e-175: 513: 68.98		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		582503 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		1288632 PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		680490 TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53		RC3H2_HUMAN (1-1191): 0: 1105: 100.00
+	Hs
		582333 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		1136223 PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33		RC3H1_HUMAN (1-1108): 0: 788: 49.30
+	Hs
		516595 PABP1_HUMAN (1-644): 0: 542: 74.54		KMT2C_HUMAN (351-895): 4.49e-14: 79.7: 9.35
+	Hs
		582292 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21
+	Hs
		582417 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		PRG4_HUMAN (469-824): 3.07e-09: 63.7: 13.04