Protein: NPL4
Nuclear protein localization protein 4 homolog (Protein NPL4)

Gene: NPL4, NPLOC4
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q8TAT6

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

934886

TERA
Transitional endoplasmic reticulum ATPase

29

6

Small-scale

0.992

High

508313

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

10

2

Small-scale

0.973

High

1347626

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

17

7

Small-scale

0.762

High

242350

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.754

High

1347669

FAF1
FAS-associated factor 1

6

9

Small-scale

0.726

High

543241

UBL4A
Ubiquitin-like protein 4A

1

4

High-throughput

0.691

High

1347643

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.687

High

987422

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.656

High

1347630

FAF2
FAS-associated factor 2

3

8

High-throughput

0.650

High

1347646

ASPC1
Tether containing UBX domain for GLUT4

3

1

High-throughput

0.650

High

1347671

NSF1C
NSFL1 cofactor p47

3

2

Small-scale

0.640

High

1347647

UBXN6
UBX domain-containing protein 6

3

1

Small-scale

0.633

High

547331

CP19A
Aromatase

2

1

High-throughput

0.628

High

425575

ISG15
Ubiquitin-like protein ISG15

1

4

Small-scale

0.618

High

1347666

UBQL2
Ubiquilin-2

1

2

High-throughput

0.618

High

320729

UBXN7
UBX domain-containing protein 7

2

7

High-throughput

0.611

High

258311

TRI13
E3 ubiquitin-protein ligase TRIM13

2

0

High-throughput

0.602

High

664994

ERD21
ER lumen protein-retaining receptor 1

2

0

High-throughput

0.602

High

1205388

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

2

0

High-throughput

0.602

High

1347633

VCIP1
Deubiquitinating protein VCPIP1

2

0

High-throughput

0.585

High

1347635

UBX10
UBX domain-containing protein 10

2

0

High-throughput

0.585

High

1347661

EKI2
Ethanolamine kinase 2

2

0

High-throughput

0.585

High

1347668

AMFR
E3 ubiquitin-protein ligase AMFR

2

1

Small-scale

0.584

High

1194101

VP26B
Vacuolar protein sorting-associated protein 26B

2

0

High-throughput

0.580

High

1155567

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.576

High

788968

TGFR2
TGF-beta receptor type-2

2

0

High-throughput

0.575

High

142143

NPT3
Sodium-dependent phosphate transport protein 3

2

2

High-throughput

0.574

High

1043865

KCNC4
Voltage-gated potassium channel KCNC4

2

2

High-throughput

0.574

High

1276233

ATG9A
Autophagy-related protein 9A

2

1

High-throughput

0.574

High

401180

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

Small-scale

0.561

High

951284

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

122629

UBXN8
UBX domain-containing protein 8

1

5

High-throughput

0.536

High

1046390

UBXN1
UBX domain-containing protein 1

1

6

High-throughput

0.536

High

1185816

PTHD3
Patched domain-containing protein 3

1

1

High-throughput

0.536

High

1168613

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

2

High-throughput

0.515

High

275698

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.513

High

431195

LA
Lupus La protein

1

0

High-throughput

0.513

High

890755

PSN2
Presenilin-2

1

0

High-throughput

0.513

High

1272405

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

1347627

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

0

High-throughput

0.513

High

248609

FADS1
Acyl-CoA

1

1

High-throughput

0.489

High

538789

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.489

High

595081

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.489

High

720588

AA1R
Adenosine receptor A1

1

1

High-throughput

0.489

High

1142106

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

1193266

SV2C
Synaptic vesicle glycoprotein 2C

1

2

High-throughput

0.489

High

1228390

SE1L3
Protein sel-1 homolog 3

1

1

High-throughput

0.489

High

1339969

OR6M1
Olfactory receptor 6M1

1

1

High-throughput

0.489

High

1339972

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

1347663

SC5A4
Probable glucose sensor protein SLC5A4

1

2

High-throughput

0.489

High

1347670

CP8B1
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase

1

1

High-throughput

0.489

High

1347675

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.489

High

1347679

FADS3
Fatty acid desaturase 3

1

1

High-throughput

0.489

High

955396

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

1042895

ERCC6
DNA excision repair protein ERCC-6

1

0

High-throughput

0.480

High

1098812

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.480

High

1218608

OTU1
Ubiquitin thioesterase OTU1

1

1

Small-scale

0.479

High

1254741

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1280351

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1347623

ZFN2B
AN1-type zinc finger protein 2B

1

1

Small-scale

0.479

High

1347631

RN185
E3 ubiquitin-protein ligase RNF185

1

1

High-throughput

0.479

High

1347651

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

Small-scale

0.479

High

1347657

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

Small-scale

0.479

High

1347664

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.479

High

1347667

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.479

High

260200

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

305844

DXO
Decapping and exoribonuclease protein

1

0

Small-scale

0.458

High

315800

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

386002

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

414261

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

458449

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.458

High

578686

GLNA
Glutamine synthetase

1

0

Small-scale

0.458

High

683490

IKBA
NF-kappa-B inhibitor alpha

1

0

Small-scale

0.458

High

698921

CALX
Calnexin

1

0

High-throughput

0.458

High

719160

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

768700

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831101

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

888200

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

904022

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

937183

ADK
Adenosine kinase

1

0

High-throughput

0.458

High

1088923

TP53B
TP53-binding protein 1

1

0

Small-scale

0.458

High

1121278

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

1123728

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1138419

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1150881

CIP4
Cdc42-interacting protein 4

1

0

High-throughput

0.458

High

1211750

UBX11
UBX domain-containing protein 11

1

0

High-throughput

0.458

High

1289471

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1333673

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.458

High

1340054

SVIP
Small VCP/p97-interacting protein

1

0

Small-scale

0.458

High

1347622

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

1347625

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1347628

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1347629

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.458

High

1347634

IFT74
Intraflagellar transport protein 74 homolog

1

0

High-throughput

0.458

High

1347636

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1347640

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

1347641

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1347644

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1347645

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1347650

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1347655

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1347656

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1347658

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1347665

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1347672

POLH
DNA polymerase eta

1

0

Small-scale

0.458

High

1347674

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

1347677

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

0

Small-scale

0.458

High

642980

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

1031467

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1347652

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

48246

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.426

High

143459

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

613408

VINC
Vinculin

1

0

High-throughput

0.426

High

1099735

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.426

High

1147803

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1209419

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1347642

PIGQ
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q

1

0

High-throughput

0.426

High

1347680

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.426

High

1347681

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.426

High

97252

E9PS44
Interferon induced transmembrane protein 3

1

1

High-throughput

0.407

High

137359

NPT4
Sodium-dependent phosphate transport protein 4

1

1

High-throughput

0.407

High

855358

5HT3A
5-hydroxytryptamine receptor 3A

1

1

High-throughput

0.407

High

926807

VMAT1
Chromaffin granule amine transporter

1

2

High-throughput

0.407

High

1194525

SL9C1
Solute carrier family 9 member C1

1

1

High-throughput

0.407

High

1215254

SL9C2
Sodium/hydrogen exchanger 11

1

1

High-throughput

0.407

High

1325642

SVOPL
Putative transporter SVOPL

1

3

High-throughput

0.407

High

1326590

CTL3
Choline transporter-like protein 3

1

1

High-throughput

0.407

High

1336020

CTL5
Choline transporter-like protein 5

1

1

High-throughput

0.407

High

1347648

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

1

High-throughput

0.407

High

1347649

SC5A7
High affinity choline transporter 1

1

2

High-throughput

0.407

High

1347673

S22AE
Solute carrier family 22 member 14

1

2

High-throughput

0.407

High

1347639

KCNKG
Potassium channel subfamily K member 16

3

0

High-throughput

0.347

High

1071247

TMM62
Transmembrane protein 62

2

0

High-throughput

0.318

High

1206669

LRC73
Leucine-rich repeat-containing protein 73

2

0

High-throughput

0.313

High

1207727

TMM31
Transmembrane protein 31

2

0

High-throughput

0.313

High

1347653

VIAAT
Vesicular inhibitory amino acid transporter

2

0

High-throughput

0.313

High

1316655

S38A6
Solute carrier family 38 member 6

2

0

High-throughput

0.298

High

49805

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

320479

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

1010499

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1333573

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1347660

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

1347676

O10H1
Olfactory receptor 10H1

1

0

High-throughput

0.279

Low

892158

GRAK
Granzyme K

1

0

Small-scale

0.261

Low

48163

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.249

Low

106320

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

412293

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

548354

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.249

Low

1256524

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

1322905

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1324019

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1347659

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1347662

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

163387

GBRD
Gamma-aminobutyric acid receptor subunit delta

1

0

High-throughput

0.232

Low

539727

ACHB
Acetylcholine receptor subunit beta

1

0

High-throughput

0.232

Low

1288432

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

1292702

IT70A
Intraflagellar transport protein 70A

1

0

High-throughput

0.232

Low

1335637

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1337032

TM104
Transmembrane protein 104

1

0

High-throughput

0.232

Low

1347624

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low

1347632

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low

1347637

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low

1347638

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low

1347654

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.232

Low

1347678

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025