HitPredict

Interactor 1: PABP4 (Q13310)
Polyadenylate-binding protein 4 (PABP-4) (Poly(A)-binding protein 4) (Activated-platelet protein 1) (APP-1) (Inducible poly(A)-binding protein) (iPABP)
Gene: PABPC4

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:1990904 - ribonucleoprotein complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 482
+	Hs
		516742 PABP1_HUMAN (1-644): 0: 542: 74.54		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		1030211 PABP4_HUMAN (1-644): 0: 585: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		516494 PABP1_HUMAN (1-644): 0: 542: 74.54		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1031413 PABP4_HUMAN (1-644): 0: 585: 100.00		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		516621 PABP1_HUMAN (1-644): 0: 542: 74.54		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		582556 NUCL_HUMAN (2-89): 1.4e-20: 98.4: 31.82		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Sc
		376881 PABP_YEAST (2-290): 4.28e-66: 228: 30.07		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		680445 TIA1_HUMAN (4-109): 7.62e-12: 69.5: 24.53		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Zm
		22429 A0A1D6I0G1_MAIZE (1-89): 2.48e-16: 84.9: 30.34		A0A1D6Q2L8_MAIZE (6-475): 6.16e-65: 218: 23.80
+	Hs
		1049508 PABP5_HUMAN (4-93): 1.22e-15: 81: 23.33		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69