Protein: C1TC
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TC, MTHFD1
Organism: Homo sapiens
Interactions: 206
UniProt ID: P11586

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001843 - neural tube closure
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004486 - methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

226371

PRKN
E3 ubiquitin-protein ligase parkin

4

4

High-throughput

0.686

High

513945

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.650

High

368885

ESR1
Estrogen receptor

3

2

Small-scale

0.641

High

514002

CUL3
Cullin-3

2

3

High-throughput

0.611

High

514088

CAH10
Carbonic anhydrase-related protein 10

2

0

High-throughput

0.585

High

513952

CDK2
Cyclin-dependent kinase 2

2

1

High-throughput

0.584

High

513948

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

514092

PD1L1
Programmed cell death 1 ligand 1

2

0

Small-scale

0.559

High

513991

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

437841

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.536

High

452592

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

513964

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

513980

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

513983

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

514001

CUL2
Cullin-2

1

3

High-throughput

0.536

High

514035

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

514050

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

514084

PAK6
Serine/threonine-protein kinase PAK 6

1

2

High-throughput

0.536

High

514110

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

345795

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

513946

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.533

High

513955

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.533

High

513961

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

513951

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.515

High

513966

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

513993

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.515

High

514109

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.515

High

128412

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

201191

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

336333

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

373602

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

439770

NEP
Neprilysin

1

0

Small-scale

0.513

High

496177

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

513992

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

513998

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.513

High

514060

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

514064

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

514096

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

513958

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.489

High

514051

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.489

High

125120

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

153550

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.479

High

177804

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

213470

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.479

High

294306

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

298099

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

326401

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

384173

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

397744

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

428896

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

431474

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

475286

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.479

High

503329

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

513956

PML
Protein PML

1

4

High-throughput

0.479

High

513957

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

513959

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

513960

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

513967

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

513969

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

513972

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

513976

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

1

High-throughput

0.479

High

513979

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

513984

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

513985

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

513986

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

513987

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

513994

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

513997

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

513999

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

514000

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

514003

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

514006

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

514008

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

514009

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

514010

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.479

High

514011

NONO
Non-POU domain-containing octamer-binding protein

1

2

Small-scale

0.479

High

514013

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

514014

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.479

High

514015

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

514031

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.479

High

514034

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

514037

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

514041

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

514043

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

514045

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

514047

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

514052

TITIN
Titin

1

1

High-throughput

0.479

High

514054

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

514055

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

514056

ARMC5
Armadillo repeat-containing protein 5

1

3

High-throughput

0.479

High

514058

SPDLY
Protein Spindly

1

2

High-throughput

0.479

High

514062

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

514065

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

514067

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

514068

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

514069

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

514070

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

4

High-throughput

0.479

High

514074

GAN
Gigaxonin

1

2

High-throughput

0.479

High

514075

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

514078

Q9H4D1
Protein kinase

1

4

High-throughput

0.479

High

514081

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

514082

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

514083

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

514085

ANLN
Anillin

1

2

High-throughput

0.479

High

514095

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

514097

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

514098

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

514099

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

514101

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

514104

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

514089

DJC17
DnaJ homolog subfamily C member 17

1

2

High-throughput

0.470

High

514093

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.470

High

129669

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

150836

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

302842

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

354262

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

385990

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

513949

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

513953

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

513971

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

513973

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

513974

IST1
IST1 homolog

1

0

High-throughput

0.458

High

513975

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

513978

CD81
CD81 antigen

1

0

High-throughput

0.458

High

513988

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

513989

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

513990

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

513996

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

514007

CUL7
Cullin-7

1

0

High-throughput

0.458

High

514019

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

514020

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.458

High

514021

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

514022

CDC73
Parafibromin

1

0

High-throughput

0.458

High

514023

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

514024

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

514032

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

514044

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

514046

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

514049

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

0

Small-scale

0.458

High

514053

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

514061

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

514066

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

514073

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

514076

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

514087

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

514102

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

514107

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

514108

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

513981

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

514079

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.457

High

305929

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

330828

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.445

High

371349

ANGI
Angiogenin

1

1

High-throughput

0.445

High

513950

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

High-throughput

0.445

High

513977

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

513995

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

514016

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

514025

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.445

High

514042

RN169
E3 ubiquitin-protein ligase RNF169

1

2

Small-scale

0.445

High

514072

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

514077

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

243850

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

513947

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

513954

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.437

High

513962

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

513963

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.437

High

513965

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

513968

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

514005

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

514012

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

514017

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

2

Small-scale

0.437

High

514026

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

514027

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

514029

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

514036

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

514038

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

514048

FBX25
F-box only protein 25

1

1

High-throughput

0.437

High

514063

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.437

High

514071

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

514080

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

514086

ANM8
Protein arginine N-methyltransferase 8

1

4

Small-scale

0.437

High

514090

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

514091

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

514094

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

514100

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.437

High

514105

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

907

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

513982

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

514059

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

514103

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

401318

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

513970

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

514004

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.279

Low

329290

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

514033

IQCH
IQ domain-containing protein H

1

0

High-throughput

0.269

Low

231981

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.261

Low

229584

K0513
Uncharacterized protein KIAA0513

1

0

High-throughput

0.249

Low

351707

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

398819

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.249

Low

514018

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

514028

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

514030

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

514040

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

514057

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.249

Low

514106

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.249

Low

514039

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024