HitPredict

Interactor 1: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	28943310, 14519663, 29656893, 20026654, 12607005, 18006705
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, enzymatic study, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 3056 Hs			1 2089
+	Hs
		1018942 ATM_HUMAN (1-3056): 0: 3806: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		554305 ATM_HUMAN (1-3056): 0: 3806: 100.00		MUC1_HUMAN (762-1525): 1.68e-11: 72: 18.23
+	Hs
		1018945 ATR_HUMAN (1223-3056): 0: 1214: 20.34		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		801124 ATR_HUMAN (1223-3056): 0: 1214: 20.34		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		1057035 TRRAP_HUMAN (1874-3056): 0: 683: 12.97		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		944242 PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1377813 TRRAP_HUMAN (1874-3056): 0: 683: 12.97		NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36
+	Hs
		801480 TRRAP_HUMAN (1874-3056): 0: 683: 12.97		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		787371 PK3CB_HUMAN (2385-3011): 9.82e-99: 348: 13.76		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		801319 SMG1_HUMAN (2626-2961): 7.72e-90: 331: 29.12		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53