HitPredict

Interactor 1: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Interactor 2: SIR7 (Q9NRC8)
NAD-dependent protein deacetylase sirtuin-7 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-7) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 7) (SIR2-like protein 7)
Gene: SIRT7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22586326
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0006974 - DNA damage response and 1 others more... GO:0035861 - site of double-strand break
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 3056 Hs			1 400
+	Hs
		1038176 ATR_HUMAN (1223-3056): 0: 1214: 20.34		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1038136 ATR_HUMAN (1223-3056): 0: 1214: 20.34		SIR2_HUMAN (75-380): 1.48e-97: 298: 21.26
+	Hs
		787578 MTOR_HUMAN (1846-3055): 0: 843: 16.65		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1344552 TRRAP_HUMAN (1874-3056): 0: 683: 12.97		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		787541 MTOR_HUMAN (1846-3055): 0: 843: 16.65		SIR1_HUMAN (78-380): 5.06e-78: 257: 19.94
+	Hs
		944451 PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20		SIR7_HUMAN (1-400): 0: 535: 100.00
+	Hs
		1236593 TRRAP_HUMAN (1874-3056): 0: 683: 12.97		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		944327 PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87
+	Hs
		1236449 SMG1_HUMAN (2626-2961): 7.72e-90: 331: 29.12		SIR6_HUMAN (77-368): 3.24e-100: 303: 38.87