HitPredict

Interactor 1: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Interactor 2: CEA21 (Q3KPI0)
Carcinoembryonic antigen-related cell adhesion molecule 21
Gene: CEACAM21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ig_3~fn3, V-set~fn3, Ig_3~I-set, I-set~V-set, Ig_3~Ig_3, Ig_3~V-set
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1948 Hs			1 293
+	Hs
		68228 PTPRS_HUMAN (1-1948): 0: 1690: 100.00		HECA2_HUMAN (25-292): 2.84e-49: 171: 20.62
+	Hs
		685236 PTPRS_HUMAN (1-1948): 0: 1690: 100.00		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Hs
		489970 PTPRF_HUMAN (1-1948): 0: 1528: 65.42		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		68222 PTPRF_HUMAN (1-1948): 0: 1528: 65.42		HECA2_HUMAN (25-292): 2.84e-49: 171: 20.62
+	Mm
		56906 PTPRA_MOUSE (1168-1948): 0: 802: 37.59		PTPRF_MOUSE (25-173): 8.15e-10: 61.8: 16.78
+	Hs
		1108780 SDK2_HUMAN (3-1422): 1.73e-122: 432: 16.47		CEA21_HUMAN (1-293): 4.87e-75: 233: 100.00
+	Hs
		685250 SDK2_HUMAN (3-1422): 1.73e-122: 432: 16.47		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Hs
		572628 PTPRJ_HUMAN (1651-1945): 1.75e-106: 375: 37.29		VGFR1_HUMAN (17-239): 1.67e-12: 69.7: 14.58
+	Hs
		1264775 NEO1_HUMAN (322-1447): 6.5e-95: 341: 13.80		TITIN_HUMAN (62-258): 8.3e-09: 58.7: 13.89
+	Hs
		441175 PTPRC_HUMAN (450-1662): 1.43e-85: 311: 15.29		CD22_HUMAN (42-242): 2.29e-13: 72: 18.75
+	Hs
		572587 PTPRB_HUMAN (257-1309): 2.07e-37: 157: 12.51		VGFR1_HUMAN (17-239): 1.67e-12: 69.7: 14.58
+	Hs
		1069962 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		LRIG1_HUMAN (5-283): 4.14e-39: 147: 16.14
+	Hs
		685244 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		CEAM8_HUMAN (5-253): 2.17e-20: 91.4: 15.56
+	Dm
		561765 PTP69_DROME (44-540): 2.55e-17: 91.2: 13.64		Q9VPZ7_DROME (25-147): 2.85e-09: 59.9: 11.29
+	Hs
		1069952 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		PXDN_HUMAN (1-137): 3.81e-14: 74.5: 16.67
+	Hs
		1069932 PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72		LRIG3_HUMAN (17-154): 1.15e-10: 64: 14.29