Protein: TFAP4
Transcription factor AP-4 (Activating enhancer-binding protein 4) (Class C basic helix-loop-helix protein 41) (bHLHc41)

Gene: TFAP4
Organism: Homo sapiens
Interactions: 150
UniProt ID: Q01664

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032064

FBW1B
F-box/WD repeat-containing protein 11

8

1

Small-scale

0.748

High

1032033

AJUBA
LIM domain-containing protein ajuba

2

0

High-throughput

0.742

High

1032067

FBW1A
F-box/WD repeat-containing protein 1A

6

1

Small-scale

0.735

High

1029660

FOXK2
Forkhead box protein K2

4

3

High-throughput

0.697

High

1031988

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.675

High

1032070

CABIN
Calcineurin-binding protein cabin-1

3

1

Small-scale

0.667

High

1032031

EXOS8
Exosome complex component RRP43

3

0

High-throughput

0.646

High

473921

NFIC
Nuclear factor 1 C-type

3

3

Small-scale

0.640

High

1017402

FOXK1
Forkhead box protein K1

2

2

High-throughput

0.628

High

1032014

UBN2
Ubinuclein-2

2

2

High-throughput

0.628

High

209984

CRX
Cone-rod homeobox protein

1

1

High-throughput

0.618

High

725242

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.618

High

1032041

TRAF4
TNF receptor-associated factor 4

2

1

High-throughput

0.606

High

617094

ATF1
Cyclic AMP-dependent transcription factor ATF-1

2

0

High-throughput

0.602

High

732548

ARRB2
Beta-arrestin-2

2

0

High-throughput

0.602

High

926646

HIRA
Protein HIRA

2

0

High-throughput

0.602

High

1032003

CTC1
CST complex subunit CTC1

2

0

High-throughput

0.602

High

1032025

TRIB2
Tribbles homolog 2

2

0

High-throughput

0.602

High

1032048

STN1
CST complex subunit STN1

2

0

High-throughput

0.602

High

192914

CLOCK
Circadian locomoter output cycles protein kaput

1

0

Small-scale

0.586

High

685160

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.586

High

1032001

USF2
Upstream stimulatory factor 2

1

0

Small-scale

0.586

High

1032046

ZHX3
Zinc fingers and homeoboxes protein 3

1

0

Small-scale

0.586

High

992140

SKP1
S-phase kinase-associated protein 1

2

0

Small-scale

0.585

High

1031982

SUH
Recombining binding protein suppressor of hairless

2

0

High-throughput

0.585

High

259812

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

872213

SOX2
Transcription factor SOX-2

2

2

Small-scale

0.584

High

1031987

NFIA
Nuclear factor 1 A-type

2

4

Small-scale

0.584

High

1031998

NFIX
Nuclear factor 1 X-type

2

3

High-throughput

0.584

High

1031984

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1032009

SMBT2
Scm-like with four MBT domains protein 2

2

0

High-throughput

0.580

High

1032024

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

1032032

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1032036

UHRF2
E3 ubiquitin-protein ligase UHRF2

2

0

Small-scale

0.559

High

133106

FOXE1
Forkhead box protein E1

1

3

High-throughput

0.536

High

166143

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

937716

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.536

High

1031989

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1032038

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.536

High

1032063

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.536

High

603237

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.513

High

1022837

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

188243

HDAC3
Histone deacetylase 3

1

2

Small-scale

0.500

High

605453

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.493

High

1032028

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

706097

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

1031997

KCTD2
BTB/POZ domain-containing protein KCTD2

1

1

High-throughput

0.489

High

1032018

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.489

High

142944

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

180145

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

1

Small-scale

0.479

High

186645

HMGB3
High mobility group protein B3

1

4

Small-scale

0.479

High

239939

SOX15
Transcription factor SOX-15

1

2

High-throughput

0.479

High

274311

SIN3B
Paired amphipathic helix protein Sin3b

1

2

Small-scale

0.479

High

334546

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

424179

S10A8
Protein S100-A8

1

1

Small-scale

0.479

High

464914

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

481238

HMGB1
High mobility group protein B1

1

4

Small-scale

0.479

High

522778

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

3

Small-scale

0.479

High

522816

COT1
COUP transcription factor 1

1

3

Small-scale

0.479

High

543571

ERR1
Steroid hormone receptor ERR1

1

3

Small-scale

0.479

High

606647

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

665085

COT2
COUP transcription factor 2

1

3

Small-scale

0.479

High

687221

HMGB2
High mobility group protein B2

1

4

Small-scale

0.479

High

799003

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

886768

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.479

High

1031981

SP3
Transcription factor Sp3

1

2

Small-scale

0.479

High

1031985

TFCP2
Alpha-globin transcription factor CP2

1

2

Small-scale

0.479

High

1031992

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.479

High

1031996

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.479

High

1032005

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

Small-scale

0.479

High

1032011

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1032013

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

Small-scale

0.479

High

1032021

SMRC2
SWI/SNF complex subunit SMARCC2

1

1

Small-scale

0.479

High

1032026

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.479

High

1032027

HDAC2
Histone deacetylase 2

1

2

Small-scale

0.479

High

1032030

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

Small-scale

0.479

High

1032035

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

1

Small-scale

0.479

High

1032037

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1032040

MTA3
Metastasis-associated protein MTA3

1

2

Small-scale

0.479

High

1032042

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.479

High

1032044

SP130
Histone deacetylase complex subunit SAP130

1

2

Small-scale

0.479

High

1032049

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

Small-scale

0.479

High

1032057

TF2L1
Transcription factor CP2-like protein 1

1

2

Small-scale

0.479

High

1032058

UBIP1
Upstream-binding protein 1

1

2

Small-scale

0.479

High

1032065

YETS2
YEATS domain-containing protein 2

1

3

Small-scale

0.479

High

1032066

TTF2
Transcription termination factor 2

1

1

Small-scale

0.479

High

303323

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

0

High-throughput

0.460

High

128982

MEN1
Menin

1

0

High-throughput

0.458

High

154671

ARI1A
AT-rich interactive domain-containing protein 1A

1

0

Small-scale

0.458

High

173693

BTAF1
TATA-binding protein-associated factor 172

1

0

Small-scale

0.458

High

344922

WIZ
Protein Wiz

1

0

Small-scale

0.458

High

413649

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

550993

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

552564

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

0

High-throughput

0.458

High

697079

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.458

High

703121

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.458

High

799850

COIL
Coilin

1

0

High-throughput

0.458

High

886455

CTCF
Transcriptional repressor CTCF

1

0

Small-scale

0.458

High

933823

GEM
GTP-binding protein GEM

1

0

Small-scale

0.458

High

938153

PKNX1
Homeobox protein PKNOX1

1

0

Small-scale

0.458

High

940481

DPOE2
DNA polymerase epsilon subunit 2

1

0

Small-scale

0.458

High

979518

H4
Histone H4

1

0

High-throughput

0.458

High

981461

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

1005844

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1031986

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

1031990

CTBP1
C-terminal-binding protein 1

1

0

Small-scale

0.458

High

1031991

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

Small-scale

0.458

High

1031993

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1031994

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.458

High

1031999

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1032000

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.458

High

1032002

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1032010

ARID2
AT-rich interactive domain-containing protein 2

1

0

Small-scale

0.458

High

1032012

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1032016

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

Small-scale

0.458

High

1032020

IN80E
INO80 complex subunit E

1

0

Small-scale

0.458

High

1032022

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1032029

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

1032034

ZN462
Zinc finger protein 462

1

0

Small-scale

0.458

High

1032039

VRK1
Serine/threonine-protein kinase VRK1

1

0

Small-scale

0.458

High

1032045

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

Small-scale

0.458

High

1032047

ZN335
Zinc finger protein 335

1

0

Small-scale

0.458

High

1032051

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

Small-scale

0.458

High

1032052

BRD7
Bromodomain-containing protein 7

1

0

Small-scale

0.458

High

1032053

PRDM5
PR domain zinc finger protein 5

1

0

High-throughput

0.458

High

1032054

CHRC1
Chromatin accessibility complex protein 1

1

0

Small-scale

0.458

High

1032055

HPF1
Histone PARylation factor 1

1

0

Small-scale

0.458

High

1032056

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

1032059

THYN1
Thymocyte nuclear protein 1

1

0

Small-scale

0.458

High

1032061

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.458

High

1032062

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.458

High

1032069

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.458

High

1032006

CYTSB
Cytospin-B

1

0

High-throughput

0.426

High

1032019

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.426

High

1031983

GOGA2
Golgin subfamily A member 2

3

0

High-throughput

0.352

High

1032068

NEUR2
Sialidase-2

3

0

High-throughput

0.347

High

229272

ANGL7
Angiopoietin-related protein 7

3

0

High-throughput

0.345

High

273755

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

2

0

High-throughput

0.328

High

1032007

WIPI3
WD repeat domain phosphoinositide-interacting protein 3

2

0

High-throughput

0.328

High

683989

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

0

High-throughput

0.316

High

1032004

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

2

0

High-throughput

0.316

High

1032023

S2543
Solute carrier family 25 member 43

1

0

High-throughput

0.279

Low

1032050

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.279

Low

1032060

ARP3B
Actin-related protein 3B

1

0

High-throughput

0.279

Low

1031995

CKAP5
Cytoskeleton-associated protein 5

1

0

Small-scale

0.249

Low

1032008

MTCL3
Microtubule cross-linking factor 3

1

0

Small-scale

0.249

Low

1032015

NAV3
Neuron navigator 3

1

0

Small-scale

0.249

Low

1032017

NGEF
Ephexin-1

1

0

Small-scale

0.249

Low

51594

SPD2B
SH3 and PX domain-containing protein 2B

1

0

High-throughput

0.232

Low

1032043

NDEL1
Nuclear distribution protein nudE-like 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025