HitPredict

Interactor 1: MPP3 (Q13368)
MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)
Gene: MPP3

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030165 - PDZ domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 585 Hs			1 207
+	Hs
		1032762 MPP3_HUMAN (1-585): 1.23e-169: 496: 100.00		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Dm
		116476 M9PJD0_DROME (129-584): 1.4e-159: 502: 34.74		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Hs
		158279 MPP3_HUMAN (1-585): 1.23e-169: 496: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		1132892 MPP7_HUMAN (1-584): 1.05e-148: 442: 52.27		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		1032764 MPP3_HUMAN (1-585): 1.23e-169: 496: 100.00		SNTG2_HUMAN (26-207): 3.92e-34: 128: 26.34
+	Hs
		1132897 MPP7_HUMAN (1-584): 1.05e-148: 442: 52.27		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		1050415 MPP2_HUMAN (1-584): 1.51e-141: 424: 30.05		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		1334778 PALS2_HUMAN (10-584): 8.44e-142: 423: 31.22		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Dm
		53140 A1Z8G0_DROME (3-585): 7.7e-149: 443: 36.82		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Hs
		158288 MPP7_HUMAN (1-584): 1.05e-148: 442: 52.27		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		1050418 MPP2_HUMAN (1-584): 1.51e-141: 424: 30.05		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		1346107 PALS2_HUMAN (10-584): 8.44e-142: 423: 31.22		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158282 MPP2_HUMAN (1-584): 1.51e-141: 424: 30.05		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		158304 PALS2_HUMAN (10-584): 8.44e-142: 423: 31.22		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Rn
		292499 MPP3_RAT (1-585): 1.34e-163: 480: 90.43		DLG1_RAT (57-191): 8.24e-25: 103: 25.71
+	Dm
		1250379 Q8T5S9_DROME (3-585): 5.28e-137: 411: 35.99		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Mm
		1143555 MPP2_MOUSE (1-584): 5.31e-142: 424: 31.26		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Dm
		53136 A1Z8G0_DROME (3-585): 7.7e-149: 443: 36.82		DLG1_DROME (7-200): 5.11e-17: 80.6: 20.59
+	Hs
		1021489 MPP2_HUMAN (1-584): 1.51e-141: 424: 30.05		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Hs
		1132886 MPP7_HUMAN (1-584): 1.05e-148: 442: 52.27		SNX27_HUMAN (91-175): 3.28e-12: 66.6: 38.14