Protein: SATB2
DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2)

Gene: SATB2
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9UPW6

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1032794

SATB1
DNA-binding protein SATB1

4

2

High-throughput

0.892

High

1462468

LHX6
LIM/homeobox protein Lhx6

3

7

High-throughput

0.861

High

920372

PLK1
Serine/threonine-protein kinase PLK1

4

1

High-throughput

0.699

High

256536

TBX19
T-box transcription factor TBX19

1

5

High-throughput

0.691

High

848840

MAGAA
Melanoma-associated antigen 10

3

4

High-throughput

0.667

High

1110199

HDAC1
Histone deacetylase 1

3

3

Small-scale

0.660

High

1432499

FOXP1
Forkhead box protein P1

2

20

Small-scale

0.639

High

1091063

FOXF1
Forkhead box protein F1

2

20

High-throughput

0.628

High

65385

DPRX
Divergent paired-related homeobox

1

5

High-throughput

0.618

High

181581

TBXT
T-box transcription factor T

1

5

High-throughput

0.618

High

210149

CRX
Cone-rod homeobox protein

1

11

High-throughput

0.618

High

225142

TLX3
T-cell leukemia homeobox protein 3

1

13

High-throughput

0.618

High

226619

TLX2
T-cell leukemia homeobox protein 2

1

8

High-throughput

0.618

High

574040

HXB2
Homeobox protein Hox-B2

1

8

High-throughput

0.618

High

662300

PAX7
Paired box protein Pax-7

1

8

High-throughput

0.618

High

685389

PAX6
Paired box protein Pax-6

1

7

High-throughput

0.618

High

725340

TLX1
T-cell leukemia homeobox protein 1

1

8

High-throughput

0.618

High

851822

NKX21
Homeobox protein Nkx-2.1

1

14

High-throughput

0.618

High

877575

LHX1
LIM/homeobox protein Lhx1

1

7

High-throughput

0.618

High

895819

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.618

High

942480

GSC
Homeobox protein goosecoid

1

8

High-throughput

0.618

High

1160905

TBR1
T-box brain protein 1

1

5

High-throughput

0.618

High

1379969

LHX4
LIM/homeobox protein Lhx4

1

7

High-throughput

0.618

High

1437241

NANOG
Homeobox protein NANOG

1

12

High-throughput

0.618

High

1453590

VSX1
Visual system homeobox 1

1

8

High-throughput

0.618

High

1458649

LHX3
LIM/homeobox protein Lhx3

1

7

High-throughput

0.618

High

1091379

FOXL1
Forkhead box protein L1

2

20

High-throughput

0.611

High

1134853

NR1D2
Nuclear receptor subfamily 1 group D member 2

2

2

High-throughput

0.611

High

1144809

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

1

High-throughput

0.609

High

1136885

MO4L2
Mortality factor 4-like protein 2

2

0

High-throughput

0.602

High

1233821

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

1397061

HSFY1
Heat shock transcription factor, Y-linked

2

0

High-throughput

0.602

High

1462606

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

0

High-throughput

0.602

High

143334

NFIB
Nuclear factor 1 B-type

2

7

High-throughput

0.584

High

474381

NFIC
Nuclear factor 1 C-type

2

8

High-throughput

0.584

High

1088107

NFIA
Nuclear factor 1 A-type

2

7

High-throughput

0.584

High

1133742

NFIX
Nuclear factor 1 X-type

2

7

High-throughput

0.584

High

1397021

TRI47
E3 ubiquitin-protein ligase TRIM47

2

1

High-throughput

0.574

High

190094

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.561

High

1308733

FOXP4
Forkhead box protein P4

1

20

Small-scale

0.561

High

133143

FOXE1
Forkhead box protein E1

1

20

High-throughput

0.536

High

166207

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

186866

FOXN1
Forkhead box protein N1

1

20

High-throughput

0.536

High

221978

FOXS1
Forkhead box protein S1

1

20

High-throughput

0.536

High

430517

JUN
Transcription factor Jun

1

2

High-throughput

0.536

High

686874

S10A4
Protein S100-A4

1

3

High-throughput

0.536

High

848589

MAGA8
Melanoma-associated antigen 8

1

4

High-throughput

0.536

High

848749

MAGA9
Melanoma-associated antigen 9

1

4

High-throughput

0.536

High

937666

FOXG1
Forkhead box protein G1

1

20

High-throughput

0.536

High

937973

FOXA1
Hepatocyte nuclear factor 3-alpha

1

20

High-throughput

0.536

High

938034

FOXA3
Hepatocyte nuclear factor 3-gamma

1

20

High-throughput

0.536

High

1029786

FOXK2
Forkhead box protein K2

1

20

High-throughput

0.536

High

1054822

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

1065499

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.536

High

1085642

FOXO1
Forkhead box protein O1

1

20

High-throughput

0.536

High

1091173

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.536

High

1150272

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.536

High

1235572

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

1253583

FOXI2
Forkhead box protein I2

1

20

High-throughput

0.536

High

1368211

HDAC2
Histone deacetylase 2

1

3

High-throughput

0.536

High

1407775

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.536

High

1408314

FOXC2
Forkhead box protein C2

1

20

High-throughput

0.536

High

1420211

FOXP3
Forkhead box protein P3

1

20

High-throughput

0.536

High

1420521

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.536

High

1453810

FOXJ2
Forkhead box protein J2

1

20

High-throughput

0.536

High

1460643

FOXD3
Forkhead box protein D3

1

20

High-throughput

0.536

High

1462603

FOXA2
Hepatocyte nuclear factor 3-beta

1

20

High-throughput

0.536

High

1432540

P63
Tumor protein 63

1

2

Small-scale

0.534

High

186353

RA51B
DNA repair protein RAD51 homolog 2

1

0

High-throughput

0.513

High

208917

ZBT24
Zinc finger and BTB domain-containing protein 24

1

0

High-throughput

0.513

High

384583

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.513

High

517837

GLI4
Zinc finger protein GLI4

1

0

High-throughput

0.513

High

833798

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

886616

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

1450393

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1452155

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

317040

MTA2
Metastasis-associated protein MTA2

1

5

Small-scale

0.501

High

652437

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.489

High

706352

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

762259

TRY3
Trypsin-3

1

1

High-throughput

0.489

High

1323709

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

1

High-throughput

0.489

High

1420483

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.479

High

240015

SOX15
Transcription factor SOX-15

1

13

High-throughput

0.479

High

243768

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

6

Small-scale

0.479

High

247038

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

404550

GCR
Glucocorticoid receptor

1

2

High-throughput

0.479

High

414867

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

487889

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

533980

IRF1
Interferon regulatory factor 1

1

2

High-throughput

0.479

High

540971

ERG
Transcriptional regulator ERG

1

5

High-throughput

0.479

High

590508

GATA1
Erythroid transcription factor

1

4

High-throughput

0.479

High

662519

GATA2
Endothelial transcription factor GATA-2

1

4

High-throughput

0.479

High

662676

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

4

High-throughput

0.479

High

703216

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

775934

HNF1B
Hepatocyte nuclear factor 1-beta

1

9

High-throughput

0.479

High

776153

SOX5
Transcription factor SOX-5

1

11

High-throughput

0.479

High

776267

SOX6
Transcription factor SOX-6

1

13

High-throughput

0.479

High

834094

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

High-throughput

0.479

High

837109

ELK3
ETS domain-containing protein Elk-3

1

7

High-throughput

0.479

High

872897

SOX2
Transcription factor SOX-2

1

13

High-throughput

0.479

High

903521

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

6

Small-scale

0.479

High

938522

PAX9
Paired box protein Pax-9

1

7

High-throughput

0.479

High

1040093

PAX2
Paired box protein Pax-2

1

7

High-throughput

0.479

High

1056664

PAX8
Paired box protein Pax-8

1

9

High-throughput

0.479

High

1088620

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

1091266

FOXI1
Forkhead box protein I1

1

20

High-throughput

0.479

High

1141368

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

1145849

IRF4
Interferon regulatory factor 4

1

2

High-throughput

0.479

High

1151312

MED1
Mediator of RNA polymerase II transcription subunit 1

1

1

Small-scale

0.479

High

1156717

NF2L2
Nuclear factor erythroid 2-related factor 2

1

2

Small-scale

0.479

High

1351201

SP7
Transcription factor Sp7

1

1

High-throughput

0.479

High

1356520

PHF10
PHD finger protein 10

1

4

Small-scale

0.479

High

1369226

KAT2B
Histone acetyltransferase KAT2B

1

2

Small-scale

0.479

High

1401454

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1405460

FEV
Protein FEV

1

4

High-throughput

0.479

High

1413242

SOX7
Transcription factor SOX-7

1

11

High-throughput

0.479

High

1429929

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

1

Small-scale

0.479

High

1434985

SOX17
Transcription factor SOX-17

1

13

High-throughput

0.479

High

1446443

BRD7
Bromodomain-containing protein 7

1

2

Small-scale

0.479

High

1461138

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

1461297

ELF5
ETS-related transcription factor Elf-5

1

6

High-throughput

0.479

High

1462608

ETV7
Transcription factor ETV7

1

6

High-throughput

0.479

High

1430924

RPB1C
DNA-directed RNA polymerase II subunit RPB11-b2

1

2

High-throughput

0.470

High

216563

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.458

High

519438

MYB
Transcriptional activator Myb

1

0

High-throughput

0.458

High

887343

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

944767

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.458

High

1250692

BCOR
BCL-6 corepressor

1

0

High-throughput

0.458

High

1359729

PHIP
PH-interacting protein

1

0

Small-scale

0.458

High

1412837

PCGF1
Polycomb group RING finger protein 1

1

0

High-throughput

0.458

High

1462605

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High

1238009

Q6NSM0
NR1D2 protein

1

2

High-throughput

0.445

High

1453278

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

1428147

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

2

High-throughput

0.439

High

1448569

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1256121

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

922411

CRBB1
Beta-crystallin B1

1

1

High-throughput

0.407

High

1131910

COG2
Conserved oligomeric Golgi complex subunit 2

1

1

High-throughput

0.407

High

1257265

RFPLB
Ret finger protein-like 4B

3

0

High-throughput

0.347

High

1462604

KLH20
Kelch-like protein 20

3

0

High-throughput

0.347

High

1211468

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1462607

ASB3
Ankyrin repeat and SOCS box protein 3

2

0

High-throughput

0.328

High

1349058

R3GEF
Guanine nucleotide exchange factor for Rab-3A

1

0

High-throughput

0.299

High

692840

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

953839

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

1098690

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1193172

RN212
Probable E3 SUMO-protein ligase RNF212

1

0

High-throughput

0.279

Low

1402742

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1430004

SHRPN
Sharpin

1

0

High-throughput

0.279

Low

1439080

CPNE5
Copine-5

1

0

High-throughput

0.279

Low

995900

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1135860

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

1453496

ARHGC
Rho guanine nucleotide exchange factor 12

1

0

High-throughput

0.249

Low

1458829

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.249

Low

1260669

CCD80
Coiled-coil domain-containing protein 80

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025