HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	32707033, 25036637
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 344
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (3-343): 1.2e-140: 408: 26.91
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (3-343): 2.05e-138: 403: 28.05
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (3-343): 6.77e-137: 399: 28.53
+	Hs
		568651 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Hs
		160553 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AURKA_HUMAN (1-334): 2.45e-133: 387: 58.89
+	Hs
		609666 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		610723 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KAPCB_HUMAN (36-342): 2.47e-133: 385: 26.50
+	Hs
		1035054 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AURKC_HUMAN (35-337): 4.3e-133: 383: 75.91
+	Hs
		609664 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		118778 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		118692 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		568664 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KAPCA_HUMAN (36-342): 1.66e-134: 388: 26.18
+	Rn
		193486 STIP1_RAT (265-457): 1.25e-22: 102: 18.14		AKT3_RAT (3-343): 9.7e-137: 398: 28.05
+	Hs
		609671 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66
+	Hs
		684955 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		AURKB_HUMAN (1-344): 5.7e-136: 391: 100.00
+	Hs
		609649 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		KAPCG_HUMAN (67-343): 2.85e-133: 385: 30.66