Protein: GCYB1
Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit)

Gene: GCYB1, GUCY1B1
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q02153

Gene Ontology (top 5):
GO:0004016 - adenylate cyclase activity
GO:0004383 - guanylate cyclase activity
GO:0005525 - GTP binding
GO:0005829 - cytosol
GO:0006182 - cGMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1034918

GCYA1
Guanylate cyclase soluble subunit alpha-1

4

8

Small-scale

0.898

High

752039

GCYA2
Guanylate cyclase soluble subunit alpha-2

3

8

Small-scale

0.861

High

1034974

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

2

0

High-throughput

0.770

High

1034961

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

2

6

High-throughput

0.726

High

1034957

GCYB1
Guanylate cyclase soluble subunit beta-1

1

8

Small-scale

0.647

High

287909

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

0

High-throughput

0.602

High

1034968

NOX5
NADPH oxidase 5

2

0

High-throughput

0.602

High

1034972

BBS2
BBSome complex member BBS2

2

0

High-throughput

0.602

High

1016708

MXRA7
Matrix-remodeling-associated protein 7

2

1

High-throughput

0.574

High

461372

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.561

High

713084

NOS3
Nitric oxide synthase 3

1

1

Small-scale

0.561

High

933512

S12A3
Solute carrier family 12 member 3

1

3

High-throughput

0.536

High

1034969

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

3

High-throughput

0.536

High

1034970

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.513

High

167690

LIN7A
Protein lin-7 homolog A

1

11

High-throughput

0.489

High

248436

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

1

High-throughput

0.489

High

784822

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

4

High-throughput

0.489

High

1034963

OR2M7
Olfactory receptor 2M7

1

1

High-throughput

0.489

High

1034964

OR1M1
Olfactory receptor 1M1

1

1

High-throughput

0.489

High

1034965

OR6T1
Olfactory receptor 6T1

1

2

High-throughput

0.489

High

1034966

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

High-throughput

0.489

High

1034967

ZDH12
Palmitoyltransferase ZDHHC12

1

3

High-throughput

0.489

High

1034973

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.489

High

1034975

TLR9
Toll-like receptor 9

1

1

High-throughput

0.489

High

421949

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1034958

TRAF3
TNF receptor-associated factor 3

1

2

Small-scale

0.479

High

1034976

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

Small-scale

0.479

High

231559

PRKY
Putative serine/threonine-protein kinase PRKY

1

1

High-throughput

0.445

High

105778

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1034977

S27A6
Long-chain fatty acid transport protein 6

1

4

High-throughput

0.407

High

1034960

MTFR2
Mitochondrial fission regulator 2

2

0

High-throughput

0.328

High

74468

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.279

Low

670072

NFYB
Nuclear transcription factor Y subunit beta

1

0

Small-scale

0.249

Low

1034959

NFIX
Nuclear factor 1 X-type

1

0

Small-scale

0.249

Low

1034962

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.249

Low

1034971

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.249

Low

946986

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025