HitPredict

Interactor 1: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Interactor 2: STK33 (Q9BYT3)
Serine/threonine-protein kinase 33 (EC 2.7.11.1)
Gene: STK33

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 457 Hs			1 514
+	Hs
		682173 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT2_HUMAN (4-453): 4.92e-143: 421: 24.73
+	Hs
		1035058 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT3_HUMAN (32-433): 8.83e-142: 418: 27.70
+	Hs
		681830 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		AKT1_HUMAN (32-452): 7.26e-141: 416: 25.94
+	Hs
		981051 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KPCT_HUMAN (5-448): 1.13e-136: 413: 20.65
+	Hs
		1034843 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KCC2D_HUMAN (111-406): 9.97e-133: 395: 30.20
+	Hs
		515273 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		KPSH1_HUMAN (116-388): 4.15e-51: 181: 34.80
+	Hs
		1034928 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		DCLK2_HUMAN (105-382): 1.68e-48: 180: 36.07
+	Hs
		1034974 FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00		PSKH2_HUMAN (116-381): 2.75e-47: 170: 35.21
+	Hs
		515269 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		KPSH1_HUMAN (116-388): 4.15e-51: 181: 34.80
+	Hs
		972569 FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59		PSKH2_HUMAN (116-381): 2.75e-47: 170: 35.21
+	Rn
		193486 STIP1_RAT (265-457): 1.25e-22: 102: 18.14		AKT3_RAT (32-427): 3.17e-139: 412: 27.11
+	Hs
		1053253 FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23		KCC2A_HUMAN (111-485): 1.98e-131: 392: 24.67
+	Hs
		684698 STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62		KCC2D_HUMAN (111-406): 9.97e-133: 395: 30.20
+	Hs
		932943 FKB1B_HUMAN (41-138): 1.43e-24: 99.4: 50.00		KCC2D_HUMAN (111-406): 9.97e-133: 395: 30.20
+	Hs
		118682 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		KPSH1_HUMAN (116-388): 4.15e-51: 181: 34.80
+	Hs
		118782 AIP_HUMAN (144-414): 1.52e-49: 173: 16.72		PSKH2_HUMAN (116-381): 2.75e-47: 170: 35.21