Protein: KPCG
Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13)

Gene: KPCG, PRKCG
Organism: Homo sapiens
Interactions: 80
UniProt ID: P05129

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0004698 - calcium,diacylglycerol-dependent serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

424632

KPCA
Protein kinase C alpha type

6

17

High-throughput

0.945

High

424620

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.817

High

424621

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.817

High

424634

DNJA1
DnaJ homolog subfamily A member 1

2

13

High-throughput

0.737

High

424662

CDC37
Hsp90 co-chaperone Cdc37

2

11

High-throughput

0.737

High

424619

KPCB
Protein kinase C beta type

1

17

High-throughput

0.691

High

424657

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

High-throughput

0.691

High

424659

RCN2
Reticulocalbin-2

2

6

High-throughput

0.659

High

424666

NOXA1
NADPH oxidase activator 1

1

3

High-throughput

0.656

High

424643

RGS2
Regulator of G-protein signaling 2

1

4

Small-scale

0.647

High

424648

GSK3A
Glycogen synthase kinase-3 alpha

1

19

Small-scale

0.647

High

424649

EPHB1
Ephrin type-B receptor 1

1

19

Small-scale

0.647

High

424656

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

20

Small-scale

0.647

High

424658

ARHG7
Rho guanine nucleotide exchange factor 7

1

9

Small-scale

0.647

High

424667

ARHGP
Rho guanine nucleotide exchange factor 25

1

15

Small-scale

0.647

High

424669

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

424677

DNJC5
DnaJ homolog subfamily C member 5

1

2

Small-scale

0.647

High

424678

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

14

Small-scale

0.647

High

424668

DJC10
DnaJ homolog subfamily C member 10

1

7

High-throughput

0.618

High

410512

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

424617

KPCG
Protein kinase C gamma type

1

17

High-throughput

0.618

High

424635

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

424641

STAT3
Signal transducer and activator of transcription 3

1

8

Small-scale

0.618

High

424644

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

17

Small-scale

0.618

High

424651

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

424652

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.618

High

424664

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

346802

BAG2
BAG family molecular chaperone regulator 2

2

5

High-throughput

0.571

High

348314

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

3

High-throughput

0.571

High

415266

HSPB1
Heat shock protein beta-1

2

13

High-throughput

0.571

High

424618

ADT2
ADP/ATP translocase 2

2

12

High-throughput

0.571

High

424624

CH60
60 kDa heat shock protein, mitochondrial

2

5

High-throughput

0.571

High

424625

HSP7C
Heat shock cognate 71 kDa protein

2

12

High-throughput

0.571

High

424627

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

424628

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

11

High-throughput

0.571

High

424631

HSP76
Heat shock 70 kDa protein 6

2

12

High-throughput

0.571

High

424636

STIP1
Stress-induced-phosphoprotein 1

2

5

High-throughput

0.571

High

424640

LONM
Lon protease homolog, mitochondrial

2

6

High-throughput

0.571

High

424650

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

11

High-throughput

0.571

High

424653

TBB4B
Tubulin beta-4B chain

2

20

High-throughput

0.571

High

424655

S25A3
Solute carrier family 25 member 3

2

17

High-throughput

0.571

High

424675

TCF25
Ribosome quality control complex subunit TCF25

2

1

High-throughput

0.571

High

424684

NS1BP
Influenza virus NS1A-binding protein

2

6

High-throughput

0.571

High

424645

GRIA4
Glutamate receptor 4

1

8

Small-scale

0.561

High

424665

RBP10
Ran-binding protein 10

1

7

Small-scale

0.561

High

424670

SAMD3
Sterile alpha motif domain-containing protein 3

1

0

High-throughput

0.556

High

424682

IBTK
Inhibitor of Bruton tyrosine kinase

1

7

Small-scale

0.553

High

240039

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

11

High-throughput

0.521

High

424660

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

11

High-throughput

0.521

High

424661

LTBP1
Latent-transforming growth factor beta-binding protein 1

2

5

High-throughput

0.521

High

424663

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

2

High-throughput

0.521

High

297398

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

High-throughput

0.515

High

424622

K1C19
Keratin, type I cytoskeletal 19

1

10

High-throughput

0.515

High

424671

CCHCR
Coiled-coil alpha-helical rod protein 1

1

6

High-throughput

0.508

High

424680

PICK1
PRKCA-binding protein

1

8

High-throughput

0.508

High

345033

RIGI
Antiviral innate immune response receptor RIG-I

1

11

Small-scale

0.501

High

421289

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

424048

ITB2
Integrin beta-2

1

16

Small-scale

0.501

High

424623

TAU
Microtubule-associated protein tau

1

13

Small-scale

0.501

High

424626

TOP2A
DNA topoisomerase 2-alpha

1

6

Small-scale

0.501

High

424629

GFAP
Glial fibrillary acidic protein

1

11

Small-scale

0.501

High

424637

SDC2
Syndecan-2

1

4

Small-scale

0.501

High

424638

HSP74
Heat shock 70 kDa protein 4

1

19

Small-scale

0.501

High

424639

CTNB1
Catenin beta-1

1

6

Small-scale

0.501

High

424642

CASR
Extracellular calcium-sensing receptor

1

8

Small-scale

0.501

High

424654

DAB2
Disabled homolog 2

1

12

Small-scale

0.501

High

424676

TRIM5
Tripartite motif-containing protein 5

1

10

Small-scale

0.501

High

424679

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

2

Small-scale

0.501

High

424681

SCN3A
Sodium channel protein type 3 subunit alpha

1

1

Small-scale

0.501

High

424683

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

424672

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.493

High

137171

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.486

High

424630

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

3

Small-scale

0.479

High

424633

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

7

Small-scale

0.479

High

424646

GBRA4
Gamma-aminobutyric acid receptor subunit alpha-4

1

3

Small-scale

0.479

High

424674

RANB9
Ran-binding protein 9

1

7

Small-scale

0.479

High

424647

HSP77
Putative heat shock 70 kDa protein 7

1

15

High-throughput

0.445

High

105113

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

424673

F167A
Protein FAM167A

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025