HitPredict

Interactor 1: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PH, CAMSAP_CH~PH, PH~PH, PH~RhoGEF
Common GO terms	GO:0001525 - angiogenesis GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 694 Hs			1 847
+	Hs
		548703 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		855792 GAB1_HUMAN (1-694): 0: 547: 100.00		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		562645 GAB1_HUMAN (1-694): 0: 547: 100.00		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		581001 GAB1_HUMAN (1-694): 0: 547: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924547 GAB1_HUMAN (1-694): 0: 547: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		1141170 GAB1_MOUSE (1-694): 0: 544: 89.93		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		1040322 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRAP_HUMAN (613-844): 1.55e-21: 95.9: 27.47
+	Hs
		562669 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		581081 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		924959 GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		50598 PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07		PKHG3_HUMAN (100-672): 2.7e-73: 263: 16.26
+	Hs
		200789 PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00		ARHG9_HUMAN (135-532): 2.03e-75: 257: 19.95
+	Mm
		1141175 GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Mm
		1114082 Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Mm
		57863 CNKR2_MOUSE (7-393): 1.86e-56: 210: 16.38		KALRN_MOUSE (152-836): 2.3e-53: 204: 12.66
+	Hs
		924730 GAB3_HUMAN (1-683): 1.81e-103: 329: 28.82		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Dm
		993221 DOS_DROME (7-655): 6.26e-82: 279: 18.50		GRAP_DROME (672-843): 3.76e-15: 77: 31.25
+	Hs
		924640 PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		1194490 CNKR2_MOUSE (7-393): 1.86e-56: 210: 16.38		ARHG7_MOUSE (747-847): 1.35e-14: 80.2: 27.72
+	Hs
		924627 PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39