HitPredict

Interactor 1: SMAD4 (Q13485)
Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)
Gene: SMAD4

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15359284, 15946939
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 552 Hs			1 922
+	Hs
		1035547 SMAD4_HUMAN (1-552): 0: 696: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		1078757 SMAD1_HUMAN (20-546): 0: 542: 34.91		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		1305881 SMAD5_HUMAN (20-546): 0: 537: 34.15		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950278 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		WWP1_HUMAN (1-922): 0: 953: 100.00
+	Hs
		950248 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Hs
		125369 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		950249 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		NED4L_HUMAN (1-919): 0: 822: 33.16
+	Hs
		808135 SMAD1_HUMAN (20-546): 0: 542: 34.91		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808240 SMAD5_HUMAN (20-546): 0: 537: 34.15		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		808087 SMAD3_HUMAN (19-549): 1.96e-176: 506: 31.22		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Hs
		1035600 SMAD4_HUMAN (1-552): 0: 696: 100.00		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1035596 SMAD4_HUMAN (1-552): 0: 696: 100.00		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1078761 SMAD1_HUMAN (20-546): 0: 542: 34.91		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Hs
		1305888 SMAD5_HUMAN (20-546): 0: 537: 34.15		SMUF1_HUMAN (6-451): 5.28e-38: 154: 15.82
+	Mm
		56826 SMAD1_MOUSE (20-546): 0: 544: 34.72		SMUF2_MOUSE (7-381): 5.96e-31: 132: 16.24
+	Hs
		1078760 SMAD1_HUMAN (20-546): 0: 542: 34.91		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Hs
		1305886 SMAD5_HUMAN (20-546): 0: 537: 34.15		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24
+	Mm
		936618 SMAD1_MOUSE (20-546): 0: 544: 34.72		SMUF1_MOUSE (276-436): 5.09e-16: 84.9: 21.14
+	Xl
		945613 P79947_XENLA (20-546): 0: 544: 34.15		SMUF1_XENLA (314-436): 3.71e-15: 81.8: 22.63
+	Hs
		1305892 SMAD5_HUMAN (20-546): 0: 537: 34.15		HECW2_HUMAN (141-582): 1.9e-12: 73.8: 16.11