Protein: MKRN3
E3 ubiquitin-protein ligase makorin-3 (EC 2.3.2.27) (RING finger protein 63) (RING-type E3 ubiquitin transferase makorin-3) (Zinc finger protein 127)

Gene: MKRN3
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q13064

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906653

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

14

Small-scale

0.910

High

1093610

MKRN3
E3 ubiquitin-protein ligase makorin-3

4

6

High-throughput

0.904

High

957597

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

18

High-throughput

0.783

High

1090611

TRAF2
TNF receptor-associated factor 2

2

4

High-throughput

0.783

High

179716

MDM4
Protein Mdm4

4

1

High-throughput

0.706

High

1093671

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

5

0

High-throughput

0.699

High

909312

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

14

High-throughput

0.698

High

957069

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

High-throughput

0.698

High

957725

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

14

High-throughput

0.698

High

970421

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

14

High-throughput

0.698

High

982175

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

14

High-throughput

0.698

High

993538

UBC9
SUMO-conjugating enzyme UBC9

1

14

High-throughput

0.698

High

995950

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

15

High-throughput

0.698

High

1093614

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

16

High-throughput

0.698

High

1093621

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

15

High-throughput

0.698

High

1093641

TRI65
E3 ubiquitin-protein ligase TRIM65

1

3

High-throughput

0.698

High

1093678

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

14

High-throughput

0.698

High

1093682

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

15

High-throughput

0.698

High

1093691

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

14

High-throughput

0.698

High

1093708

TRI34
E3 ubiquitin-protein ligase TRIM34

1

1

High-throughput

0.698

High

1093710

TRI31
E3 ubiquitin-protein ligase TRIM31

1

3

High-throughput

0.698

High

1093711

TRIM5
Tripartite motif-containing protein 5

1

2

High-throughput

0.698

High

1093742

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

14

High-throughput

0.698

High

550253

PABP1
Polyadenylate-binding protein 1

3

12

Small-scale

0.670

High

783254

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.663

High

505712

ZN688
Zinc finger protein 688

3

4

High-throughput

0.654

High

352125

MBD3
Methyl-CpG-binding domain protein 3

3

0

Small-scale

0.650

High

680856

PSA1
Proteasome subunit alpha type-1

3

0

High-throughput

0.646

High

1093698

F110A
Protein FAM110A

3

0

High-throughput

0.646

High

1093705

SCNM1
Sodium channel modifier 1

3

0

High-throughput

0.646

High

1093707

BEX2
Protein BEX2

3

0

High-throughput

0.646

High

180280

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

3

0

High-throughput

0.643

High

1061682

TLE5
TLE family member 5

3

0

High-throughput

0.643

High

1093703

TCHP
Trichoplein keratin filament-binding protein

4

1

High-throughput

0.637

High

730555

1433S
14-3-3 protein sigma

2

0

High-throughput

0.623

High

1093635

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

14

High-throughput

0.621

High

1093713

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

8

High-throughput

0.618

High

1093735

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

8

High-throughput

0.618

High

1093612

PABP4
Polyadenylate-binding protein 4

2

12

Small-scale

0.611

High

1093717

PABP3
Polyadenylate-binding protein 3

2

12

Small-scale

0.611

High

1093674

LAR4B
La-related protein 4B

2

11

High-throughput

0.611

High

72413

MI4GD
MIF4G domain-containing protein

2

3

High-throughput

0.606

High

74338

ZBT42
Zinc finger and BTB domain-containing protein 42

2

2

High-throughput

0.606

High

283469

TAD2A
Transcriptional adapter 2-alpha

2

1

High-throughput

0.606

High

473409

HCK
Tyrosine-protein kinase HCK

2

1

High-throughput

0.606

High

771558

HXD12
Homeobox protein Hox-D12

2

3

High-throughput

0.606

High

885235

HXA1
Homeobox protein Hox-A1

2

3

High-throughput

0.606

High

893688

MEOX1
Homeobox protein MOX-1

2

2

High-throughput

0.606

High

1093613

KLF1
Krueppel-like factor 1

2

3

High-throughput

0.606

High

1093615

PTK6
Protein-tyrosine kinase 6

2

1

High-throughput

0.606

High

1093640

MORN3
MORN repeat-containing protein 3

2

1

High-throughput

0.606

High

1093648

RBPS2
RNA-binding protein with multiple splicing 2

2

2

High-throughput

0.606

High

1093731

ZIM2
Zinc finger imprinted 2

2

1

High-throughput

0.606

High

1093736

IKZF3
Zinc finger protein Aiolos

2

3

High-throughput

0.606

High

1093745

MAGD1
Melanoma-associated antigen D1

2

3

High-throughput

0.606

High

1093676

RENT1
Regulator of nonsense transcripts 1

2

7

Small-scale

0.584

High

1093721

MOV10
Helicase MOV-10

2

7

Small-scale

0.584

High

1093645

ANR11
Ankyrin repeat domain-containing protein 11

2

5

High-throughput

0.584

High

169534

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.580

High

250240

VINEX
Vinexin

2

0

High-throughput

0.580

High

480117

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

590418

GATA1
Erythroid transcription factor

2

0

High-throughput

0.580

High

633669

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

715891

AQP1
Aquaporin-1

2

0

High-throughput

0.580

High

930684

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

0

High-throughput

0.580

High

933834

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

1042738

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

0

High-throughput

0.580

High

1044633

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.580

High

1093616

LAGE3
EKC/KEOPS complex subunit LAGE3

2

0

High-throughput

0.580

High

1093618

RTP5
Receptor-transporting protein 5

2

0

High-throughput

0.580

High

1093622

PKN1
Serine/threonine-protein kinase N1

2

0

High-throughput

0.580

High

1093650

ATOSB
Atos homolog protein B

2

0

High-throughput

0.580

High

1093658

STH
Saitohin

2

0

High-throughput

0.580

High

1093662

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

2

0

High-throughput

0.580

High

1093670

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.580

High

1093679

TET5B
Terminal nucleotidyltransferase 5B

2

0

High-throughput

0.580

High

1093683

ARMC5
Armadillo repeat-containing protein 5

2

0

High-throughput

0.580

High

1093686

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.580

High

1093688

ZN414
Zinc finger protein 414

2

0

High-throughput

0.580

High

1093695

ZN587
Zinc finger protein 587

2

0

High-throughput

0.580

High

1093699

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

2

0

High-throughput

0.580

High

1093706

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.580

High

1093712

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1093716

GO45
Golgin-45

2

0

High-throughput

0.580

High

1093719

STN1
CST complex subunit STN1

2

0

High-throughput

0.580

High

1093720

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

High-throughput

0.580

High

1093724

ZFP57
Zinc finger protein 57 homolog

2

0

High-throughput

0.580

High

1093729

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1093734

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

2

0

High-throughput

0.580

High

1093738

RASD1
Dexamethasone-induced Ras-related protein 1

2

0

High-throughput

0.580

High

1093740

ZN835
Zinc finger protein 835

2

0

High-throughput

0.580

High

1009194

PRR3
Proline-rich protein 3

1

3

High-throughput

0.575

High

1093620

SF01
Splicing factor 1

1

3

High-throughput

0.573

High

292829

GRAP2
GRB2-related adapter protein 2

1

1

High-throughput

0.560

High

1093677

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.560

High

227216

KRT86
Keratin, type II cuticular Hb6

2

1

High-throughput

0.553

High

300347

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.553

High

341763

K2C75
Keratin, type II cytoskeletal 75

2

1

High-throughput

0.553

High

1086392

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

1

High-throughput

0.553

High

1093617

LASP1
LIM and SH3 domain protein 1

2

1

High-throughput

0.553

High

1093624

RSPO4
R-spondin-4

2

1

High-throughput

0.553

High

1093636

TASO2
Protein TASOR 2

2

3

High-throughput

0.553

High

1093638

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

5

High-throughput

0.553

High

1093639

WDR25
WD repeat-containing protein 25

2

3

High-throughput

0.553

High

1093665

USBP1
Harmonin-binding protein USHBP1

2

2

High-throughput

0.553

High

1093666

CC185
Coiled-coil domain-containing protein 185

2

1

High-throughput

0.553

High

1093669

G45IP
Large ribosomal subunit protein mL64

2

1

High-throughput

0.553

High

1093704

KIFC3
Kinesin-like protein KIFC3

2

1

High-throughput

0.553

High

1093726

GOG6A
Golgin subfamily A member 6A

2

2

High-throughput

0.553

High

1093737

HSF4
Heat shock factor protein 4

2

2

High-throughput

0.553

High

431561

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.549

High

1093619

TCEA2
Transcription elongation factor A protein 2

1

0

High-throughput

0.549

High

1093681

SOSB2
SOSS complex subunit B2

1

0

High-throughput

0.549

High

1093746

X5D778
Ankyrin repeat domain 11 isoform A

2

5

High-throughput

0.544

High

1028174

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.541

High

1093673

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.541

High

1093680

RN166
E3 ubiquitin-protein ligase RNF166

1

3

High-throughput

0.541

High

1093709

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

5

High-throughput

0.541

High

214287

MSI1H
RNA-binding protein Musashi homolog 1

1

17

High-throughput

0.536

High

462380

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

17

High-throughput

0.536

High

1093659

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

2

High-throughput

0.536

High

75510

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

16

High-throughput

0.528

High

334406

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.523

High

464375

ERCC1
DNA excision repair protein ERCC-1

1

1

High-throughput

0.523

High

1012687

RT06
Small ribosomal subunit protein bS6m

1

2

High-throughput

0.523

High

1093689

RBM41
RNA-binding protein 41

1

19

High-throughput

0.523

High

1093692

ODAD4
Outer dynein arm-docking complex subunit 4

1

1

High-throughput

0.523

High

253557

PEX10
Peroxisome biogenesis factor 10

1

0

High-throughput

0.518

High

908741

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

1093646

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.518

High

1093714

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

1093733

RBX2
RING-box protein 2

1

0

High-throughput

0.518

High

1093611

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.515

High

1085067

KIF1A
Kinesin-like protein KIF1A

1

1

High-throughput

0.494

High

926967

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1093675

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

1093693

MIA2
Melanoma inhibitory activity protein 2

1

2

High-throughput

0.489

High

244686

ZC3H1
Zinc finger C3H1 domain-containing protein

1

3

High-throughput

0.481

High

893847

MEOX2
Homeobox protein MOX-2

1

5

High-throughput

0.481

High

286192

CSDE1
Cold shock domain-containing protein E1

1

1

High-throughput

0.479

High

615376

SON
Protein SON

1

1

High-throughput

0.479

High

1027418

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.479

High

1035583

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1093643

LARP1
La-related protein 1

1

11

High-throughput

0.479

High

1093652

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1093653

PABP2
Polyadenylate-binding protein 2

1

17

High-throughput

0.479

High

1093696

ATX2
Ataxin-2

1

4

High-throughput

0.479

High

1093727

BCLF1
Bcl-2-associated transcription factor 1

1

4

High-throughput

0.479

High

1093730

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

Small-scale

0.479

High

1093741

TR150
Thyroid hormone receptor-associated protein 3

1

5

High-throughput

0.479

High

1093743

STRAP
Serine-threonine kinase receptor-associated protein

1

1

High-throughput

0.479

High

1093744

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

108031

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

3

High-throughput

0.470

High

1081296

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

1093649

NKAP1
Uncharacterized protein NKAPD1

1

2

High-throughput

0.464

High

1093660

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

517655

ZBT48
Zinc finger and BTB domain-containing protein 48

1

0

Small-scale

0.458

High

3535

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

4

High-throughput

0.457

High

896229

PEX5
Peroxisomal targeting signal 1 receptor

1

1

High-throughput

0.439

High

946366

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

1093725

NDE1
Nuclear distribution protein nudE homolog 1

1

3

High-throughput

0.439

High

1093656

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

2

High-throughput

0.437

High

953866

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.426

High

1093747

X5DP35
NudE neurodevelopment protein 1 isoform A

1

3

High-throughput

0.417

High

1093715

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.334

High

70190

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

71799

CMA1B
Ciliary microtubule associated protein 1B

2

0

High-throughput

0.316

High

143839

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.316

High

165174

TSN4
Tetraspanin-4

2

0

High-throughput

0.316

High

219625

B2L11
Bcl-2-like protein 11

2

0

High-throughput

0.316

High

269188

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

352625

TCL1B
T-cell leukemia/lymphoma protein 1B

2

0

High-throughput

0.316

High

377056

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.316

High

399407

SLPI
Antileukoproteinase

2

0

High-throughput

0.316

High

420280

IGF1
Insulin-like growth factor 1

2

0

High-throughput

0.316

High

506722

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

605457

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

2

0

High-throughput

0.316

High

616697

ADA2C
Alpha-2C adrenergic receptor

2

0

High-throughput

0.316

High

948235

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.316

High

1093623

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.316

High

1093625

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1093626

KR192
Keratin-associated protein 19-2

2

0

High-throughput

0.316

High

1093627

KR212
Keratin-associated protein 21-2

2

0

High-throughput

0.316

High

1093628

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1093629

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

1093630

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1093631

KR197
Keratin-associated protein 19-7

2

0

High-throughput

0.316

High

1093633

GT253
Inactive glycosyltransferase 25 family member 3

2

0

High-throughput

0.316

High

1093634

AVPI1
Arginine vasopressin-induced protein 1

2

0

High-throughput

0.316

High

1093637

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1093642

TXD11
Thioredoxin domain-containing protein 11

2

0

High-throughput

0.316

High

1093644

SPAT8
Spermatogenesis-associated protein 8

2

0

High-throughput

0.316

High

1093647

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1093654

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

1093655

KRA71
Keratin-associated protein 7-1

2

0

High-throughput

0.316

High

1093657

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1093663

RIBC1
RIB43A-like with coiled-coils protein 1

2

0

High-throughput

0.316

High

1093667

TPRX1
Tetra-peptide repeat homeobox protein 1

2

0

High-throughput

0.316

High

1093668

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1093672

ACO11
Acyl-coenzyme A thioesterase 11

2

0

High-throughput

0.316

High

1093684

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1093685

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.316

High

1093687

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1093694

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.316

High

1093700

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1093701

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

2

0

High-throughput

0.316

High

1093722

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1093723

MYOZ2
Myozenin-2

2

0

High-throughput

0.316

High

1093728

STMN3
Stathmin-3

2

0

High-throughput

0.316

High

1093732

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

1093739

VP9D1
VPS9 domain-containing protein 1

2

0

High-throughput

0.316

High

1093702

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

0

High-throughput

0.299

High

1093718

F124B
Protein FAM124B

1

0

High-throughput

0.299

High

1093697

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.282

High

1092368

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

47325

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

458910

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

1093651

PEX26
Peroxisome assembly protein 26

1

0

High-throughput

0.268

Low

959465

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

1093632

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1093661

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1093664

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1093690

SPTCS
Spatacsin

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025