HitPredict

Interactor 1: G5E884 (G5E884)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: Pak1

Interactor 2: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12165471
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030335 - positive regulation of cell migration GO:0051496 - positive regulation of stress fiber assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 544 Mm			1 191
+	Hs
		564505 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Mm
		103566 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Hs
		1026226 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17
+	Rn
		723755 PAK1_RAT (1-544): 0: 563: 99.27		CDC42_RAT (1-191): 4.96e-82: 243: 100.00
+	Hs
		925244 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Mm
		103567 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC2_MOUSE (1-191): 1.1e-80: 239: 69.27
+	Mm
		292040 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Hs
		893957 PAK1_HUMAN (1-544): 0: 557: 99.08		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		950963 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		545350 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Mm
		292039 PAK1_MOUSE (1-544): 0: 551: 98.17		CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00
+	Mm
		292048 PAK1_MOUSE (1-544): 0: 551: 98.17		RHOA_MOUSE (5-191): 9.99e-82: 242: 53.48
+	Mm
		292041 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC2_MOUSE (1-191): 1.1e-80: 239: 69.27
+	Hs
		892345 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32
+	Mm
		103575 G5E884_MOUSE (1-544): 0: 561: 100.00		RHOQ_MOUSE (4-191): 3.45e-73: 221: 64.62
+	Hs
		1026182 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOU_HUMAN (4-186): 1.03e-72: 221: 58.82
+	Mm
		925809 PAK2_MOUSE (3-543): 1.86e-172: 499: 74.49		RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31
+	Rn
		1145152 PAK2_RAT (3-543): 3.07e-172: 499: 74.49		CDC42_RAT (1-191): 4.96e-82: 243: 100.00
+	Hs
		545351 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		436282 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41