HitPredict

Interactor 1: G5E884 (G5E884)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Gene: Pak1

Interactor 2: RAC2 (Q05144)
Ras-related C3 botulinum toxin substrate 2 (Protein EN-7) (p21-Rac2)
Gene: RAC2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11435472
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 544 Mm			1 192
+	Mm
		103566 G5E884_MOUSE (1-544): 0: 561: 100.00		RAC1_MOUSE (1-192): 8.27e-85: 250: 91.67
+	Hs
		925244 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC1_HUMAN (1-192): 8.27e-85: 250: 91.67
+	Mm
		292040 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC1_MOUSE (1-192): 8.27e-85: 250: 91.67
+	Hs
		545350 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC2_HUMAN (1-192): 2.35e-82: 243: 98.96
+	Hs
		564505 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOQ_HUMAN (4-187): 1.4e-81: 242: 61.96
+	Mm
		292041 PAK1_MOUSE (1-544): 0: 551: 98.17		RAC2_MOUSE (1-192): 3.73e-83: 245: 100.00
+	Rn
		723755 PAK1_RAT (1-544): 0: 563: 99.27		CDC42_RAT (1-192): 2.53e-77: 231: 69.27
+	Mm
		103565 G5E884_MOUSE (1-544): 0: 561: 100.00		CDC42_MOUSE (1-192): 2.53e-77: 231: 69.27
+	Hs
		892345 PAK1_HUMAN (1-544): 0: 557: 99.08		RAC3_HUMAN (1-191): 5.68e-79: 235: 88.48
+	Hs
		950963 PAK1_HUMAN (1-544): 0: 557: 99.08		RHOG_HUMAN (1-192): 9.49e-79: 234: 71.35
+	Hs
		893957 PAK1_HUMAN (1-544): 0: 557: 99.08		CDC42_HUMAN (1-192): 2.53e-77: 231: 69.27
+	Mm
		292039 PAK1_MOUSE (1-544): 0: 551: 98.17		CDC42_MOUSE (1-192): 2.53e-77: 231: 69.27
+	Mm
		292048 PAK1_MOUSE (1-544): 0: 551: 98.17		RHOA_MOUSE (5-192): 4.3e-76: 228: 54.26
+	Mm
		103575 G5E884_MOUSE (1-544): 0: 561: 100.00		RHOQ_MOUSE (4-192): 2.06e-71: 216: 58.97
+	Mm
		925809 PAK2_MOUSE (3-543): 1.86e-172: 499: 74.49		RAC1_MOUSE (1-192): 8.27e-85: 250: 91.67
+	Hs
		545351 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RAC2_HUMAN (1-192): 2.35e-82: 243: 98.96
+	Hs
		564507 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOQ_HUMAN (4-187): 1.4e-81: 242: 61.96
+	Hs
		892346 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RAC3_HUMAN (1-191): 5.68e-79: 235: 88.48
+	Rn
		1145152 PAK2_RAT (3-543): 3.07e-172: 499: 74.49		CDC42_RAT (1-192): 2.53e-77: 231: 69.27
+	Hs
		436282 PAK2_HUMAN (3-543): 7.82e-172: 497: 74.12		RHOC_HUMAN (5-192): 7.5e-74: 222: 54.79