HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 26612615, 29021293, 29955050, 18570872, 34942311, 35218437, 21113135, 27197231, 30561431, 34839354, 19854138, 21931591, 23972990, 15147886
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, virotrap
Interaction Type physical association, direct interaction, ubiquitination reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~PK_Tyr_Ser-Thr, CARD~Death
Common GO terms GO:0005829 - cytosol
GO:0006915 - apoptotic process
GO:0033209 - tumor necrosis factor-mediated signaling pathway
GO:0043066 - negative regulation of apoptotic process
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024