HitPredict

Interactor 1: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Interactor 2: UB2J1 (Q9Y385)
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)
Gene: UBE2J1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	19690564, 28321712, 15861135
Identification Methods	two hybrid, affinity chromatography technology, pull down, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 618 Hs			1 318
+	Hs
		919722 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849322 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895788 BIRC2_HUMAN (1-618): 0: 702: 100.00		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		927749 BIRC2_HUMAN (1-618): 0: 702: 100.00		UBE2B_HUMAN (7-154): 6.08e-60: 190: 22.52
+	Hs
		1206094 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D4_HUMAN (10-156): 3.97e-70: 216: 28.00
+	Hs
		919776 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849363 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		919721 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Hs
		849321 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895841 MIB1_HUMAN (231-616): 1.49e-51: 193: 15.83		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		895787 BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Mm
		620834 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D1_MOUSE (10-156): 1e-69: 215: 30.00
+	Hs
		919708 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D2_HUMAN (10-156): 5.15e-70: 216: 28.00
+	Mm
		620833 MDM2_MOUSE (319-617): 5.64e-35: 140: 16.21		UB2D3_MOUSE (10-156): 1.73e-68: 212: 28.00
+	Hs
		849309 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D1_HUMAN (10-156): 1e-69: 215: 30.00
+	Hs
		895778 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2D3_HUMAN (10-156): 1.73e-68: 212: 28.00
+	Hs
		851803 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2E1_HUMAN (1-156): 1.67e-64: 203: 28.30
+	Hs
		828987 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UBE2A_HUMAN (7-154): 3.69e-61: 193: 21.85
+	Hs
		927746 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UBE2B_HUMAN (7-154): 6.08e-60: 190: 22.52
+	Hs
		891403 MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56		UB2G2_HUMAN (7-142): 5.84e-58: 185: 26.00