Protein: DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (HSD17B8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (Estradiol 17-beta-dehydrogenase 8) (EC 1.1.1.62) (Protein Ke6) (Ke6) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)

Gene: DHB8, HSD17B8
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q92506

Gene Ontology (top 5):
GO:0004303 - estradiol 17-beta-dehydrogenase [NAD(P)+] activity
GO:0005739 - mitochondrion
GO:0005740 - mitochondrial envelope
GO:0005759 - mitochondrial matrix
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1326813

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

4

17

High-throughput

0.895

High

856321

IF2M
Translation initiation factor IF-2, mitochondrial

3

4

High-throughput

0.667

High

1203448

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

1363500

MOCOS
Molybdenum cofactor sulfurase

4

1

High-throughput

0.630

High

1363508

SEPT3
Neuronal-specific septin-3

4

1

High-throughput

0.630

High

912984

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

5

High-throughput

0.628

High

1162453

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

554820

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

5

High-throughput

0.536

High

884680

SYHM
Histidine--tRNA ligase, mitochondrial

1

4

High-throughput

0.536

High

1061347

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

1

High-throughput

0.536

High

1138862

SYLM
Leucine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

1200393

BOLA3
BolA-like protein 3

1

1

High-throughput

0.536

High

1310270

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1363502

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

1142611

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1363499

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1290915

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

1363511

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.458

High

1363512

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.458

High

626302

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

653471

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

1359627

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

1

High-throughput

0.445

High

1347821

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.437

High

1363510

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1219212

SUSD4
Sushi domain-containing protein 4

3

0

High-throughput

0.347

High

1363501

ZN414
Zinc finger protein 414

3

0

High-throughput

0.347

High

229276

ANGL7
Angiopoietin-related protein 7

2

0

High-throughput

0.328

High

1279012

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

163575

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.279

Low

587161

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

1363505

BEX4
Protein BEX4

1

0

High-throughput

0.279

Low

1363506

RBX2
RING-box protein 2

1

0

High-throughput

0.279

Low

1363507

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

1363509

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

238577

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

249995

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.232

Low

1363503

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low

1363504

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025