HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: TNIP1 (Q15025)
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)
Gene: TNIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	34079125, 33545068, 36574265
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 636
+	Hs
		148772 SQSTM_HUMAN (1-440): 0: 760: 100.00		CTRO_HUMAN (51-557): 1.5e-16: 86.2: 14.12
+	Mm
		1145351 SQSTM_MOUSE (1-440): 0: 731: 90.72		FTM_MOUSE (17-526): 3.12e-25: 113: 15.30
+	Hs
		1036751 SQSTM_HUMAN (1-440): 0: 760: 100.00		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		1036861 SQSTM_HUMAN (1-440): 0: 760: 100.00		CP250_HUMAN (63-566): 3.97e-11: 68.8: 11.57
+	Hs
		1036960 SQSTM_HUMAN (1-440): 0: 760: 100.00		DAPLE_HUMAN (47-529): 4.09e-09: 61.9: 12.81
+	Hs
		1063925 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00
+	Hs
		1056025 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		TNIP1_HUMAN (1-636): 6.24e-78: 262: 100.00
+	Hs
		1206000 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		1078859 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		ITSN1_HUMAN (92-469): 5.76e-14: 77.7: 11.00
+	Hs
		320063 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		SMC3_HUMAN (278-527): 2.28e-43: 169: 25.09
+	Hs
		1206041 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		CP250_HUMAN (63-566): 3.97e-11: 68.8: 11.57
+	Mm
		1118137 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		MYH10_MOUSE (2-506): 2.12e-19: 95.4: 11.16
+	Hs
		319939 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		1056089 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		RBCC1_HUMAN (161-525): 5.86e-15: 81.1: 17.12
+	Hs
		319994 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		CP250_HUMAN (63-566): 3.97e-11: 68.8: 11.57
+	Hs
		319864 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		GRDN_HUMAN (154-540): 6.14e-09: 61.6: 9.92