Protein: KIF2C
Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)

Gene: KIF2C
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q99661

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0003777 - microtubule motor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

122840

KIF2A
Kinesin-like protein KIF2A

2

18

High-throughput

0.811

High

1326638

KIF2B
Kinesin-like protein KIF2B

2

17

High-throughput

0.811

High

1210967

CE170
Centrosomal protein of 170 kDa

2

14

High-throughput

0.789

High

1152221

MARE1
Microtubule-associated protein RP/EB family member 1

9

15

Small-scale

0.754

High

1406251

KIF2C
Kinesin-like protein KIF2C

1

13

Small-scale

0.713

High

1257203

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

14

High-throughput

0.691

High

1406279

DYN3
Dynamin-3

3

3

High-throughput

0.667

High

622668

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

5

High-throughput

0.628

High

1180406

KLH40
Kelch-like protein 40

2

3

High-throughput

0.628

High

1234708

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

2

High-throughput

0.628

High

1351640

TCP1L
T-complex protein 10A homolog 1

2

1

High-throughput

0.628

High

920227

PLK1
Serine/threonine-protein kinase PLK1

2

16

Small-scale

0.624

High

1205956

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

17

Small-scale

0.622

High

1140741

KIF14
Kinesin-like protein KIF14

1

18

High-throughput

0.618

High

1294887

KI18B
Kinesin-like protein KIF18B

1

18

High-throughput

0.618

High

422967

A4
Amyloid-beta precursor protein

2

11

High-throughput

0.602

High

1108388

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.602

High

1392859

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.602

High

372949

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

1123785

DCTN1
Dynactin subunit 1

2

14

High-throughput

0.584

High

1406278

MARE3
Microtubule-associated protein RP/EB family member 3

2

15

High-throughput

0.584

High

1293805

FBX11
F-box only protein 11

2

0

High-throughput

0.576

High

336601

PPN
Papilin

2

5

High-throughput

0.574

High

396791

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

1406277

HECD1
E3 ubiquitin-protein ligase HECTD1

1

17

High-throughput

0.553

High

1257110

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.552

High

1381442

ZN566
Zinc finger protein 566

1

4

High-throughput

0.541

High

212784

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

5

High-throughput

0.536

High

214614

WDR62
WD repeat-containing protein 62

1

7

High-throughput

0.536

High

300822

KRT38
Keratin, type I cuticular Ha8

1

16

High-throughput

0.536

High

329164

RCBT2
RCC1 and BTB domain-containing protein 2

1

7

High-throughput

0.536

High

407883

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

451561

CENPB
Major centromere autoantigen B

1

1

High-throughput

0.536

High

612751

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.536

High

618728

ML12A
Myosin regulatory light chain 12A

1

10

High-throughput

0.536

High

625580

CSK22
Casein kinase II subunit alpha'

1

7

High-throughput

0.536

High

630341

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

7

High-throughput

0.536

High

692789

CALL3
Calmodulin-like protein 3

1

7

High-throughput

0.536

High

698357

MAP4
Microtubule-associated protein 4

1

14

High-throughput

0.536

High

721054

CLIP1
CAP-Gly domain-containing linker protein 1

1

12

High-throughput

0.536

High

749117

RL9
Large ribosomal subunit protein uL6

1

2

High-throughput

0.536

High

848707

MAGA9
Melanoma-associated antigen 9

1

7

High-throughput

0.536

High

859412

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

875759

PRC2A
Protein PRRC2A

1

13

High-throughput

0.536

High

882553

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.536

High

902944

DUS3
Dual specificity protein phosphatase 3

1

5

High-throughput

0.536

High

936673

BRPF1
Peregrin

1

6

High-throughput

0.536

High

1036587

SEMG2
Semenogelin-2

1

1

High-throughput

0.536

High

1058920

ZO1
Tight junction protein 1

1

16

High-throughput

0.536

High

1093164

STK4
Serine/threonine-protein kinase 4

1

19

High-throughput

0.536

High

1096921

FADD
FAS-associated death domain protein

1

2

High-throughput

0.536

High

1097725

STK3
Serine/threonine-protein kinase 3

1

17

High-throughput

0.536

High

1111219

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1200144

BOREA
Borealin

1

1

High-throughput

0.536

High

1206759

RRP12
RRP12-like protein

1

2

High-throughput

0.536

High

1207424

HABP4
Intracellular hyaluronan-binding protein 4

1

4

High-throughput

0.536

High

1214662

RBM26
RNA-binding protein 26

1

3

High-throughput

0.536

High

1220475

K2C79
Keratin, type II cytoskeletal 79

1

10

High-throughput

0.536

High

1278211

CLAP1
CLIP-associating protein 1

1

3

High-throughput

0.536

High

1286259

PCGF5
Polycomb group RING finger protein 5

1

11

High-throughput

0.536

High

1336281

LS14A
Protein LSM14 homolog A

1

5

High-throughput

0.536

High

1365580

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

1369475

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.536

High

1395691

ZN668
Zinc finger protein 668

1

2

High-throughput

0.536

High

1404337

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

1406254

CAB45
45 kDa calcium-binding protein

1

9

High-throughput

0.536

High

1406270

TBCD7
TBC1 domain family member 7

1

1

High-throughput

0.536

High

1406271

ARP3B
Actin-related protein 3B

1

6

High-throughput

0.536

High

1406274

MBD1
Methyl-CpG-binding domain protein 1

1

4

High-throughput

0.536

High

1406280

RBMX2
RNA-binding motif protein, X-linked 2

1

9

High-throughput

0.536

High

1406283

SAR1B
Small COPII coat GTPase SAR1B

1

6

High-throughput

0.536

High

692255

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.513

High

770415

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.513

High

983036

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.513

High

1054778

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1129569

ESPL1
Separin

1

0

High-throughput

0.513

High

1204389

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1330470

HORM2
HORMA domain-containing protein 2

1

0

High-throughput

0.513

High

1337518

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.513

High

1358185

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1406258

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.513

High

1406262

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1406268

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.513

High

1406272

BCCIP
BRCA2 and CDKN1A-interacting protein

1

0

High-throughput

0.513

High

1406276

FBX5
F-box only protein 5

1

0

High-throughput

0.513

High

1406281

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

822828

VHL
von Hippel-Lindau disease tumor suppressor

1

4

Small-scale

0.508

High

995219

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.508

High

170306

AURKA
Aurora kinase A

1

7

Small-scale

0.501

High

964434

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

724165

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.489

High

1105766

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

2

High-throughput

0.489

High

1179843

INSY1
Inhibitory synaptic factor 1

1

3

High-throughput

0.489

High

1217831

PR38B
Pre-mRNA-splicing factor 38B

1

5

High-throughput

0.489

High

1388526

RMXL1
RNA binding motif protein, X-linked-like-1

1

10

High-throughput

0.489

High

1393535

MR1L1
MORF4 family-associated protein 1-like 1

1

3

High-throughput

0.489

High

1406255

WDR18
WD repeat-containing protein 18

1

8

High-throughput

0.489

High

1406257

NDEL1
Nuclear distribution protein nudE-like 1

1

15

High-throughput

0.481

High

1406259

CENPH
Centromere protein H

1

0

Small-scale

0.480

High

132254

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

High-throughput

0.479

High

157774

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

159821

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

16

High-throughput

0.479

High

242701

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

260357

BRD4
Bromodomain-containing protein 4

1

11

High-throughput

0.479

High

412500

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.479

High

537772

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

573221

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.479

High

589503

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

607039

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

613154

EGR1
Early growth response protein 1

1

6

High-throughput

0.479

High

643042

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

684024

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

10

High-throughput

0.479

High

696316

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

700716

PSA5
Proteasome subunit alpha type-5

1

3

Small-scale

0.479

High

799432

BRCA1
Breast cancer type 1 susceptibility protein

1

16

High-throughput

0.479

High

831302

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

942836

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

High-throughput

0.479

High

955995

RAB8A
Ras-related protein Rab-8A

1

3

Small-scale

0.479

High

966793

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

980204

H4
Histone H4

1

5

High-throughput

0.479

High

981043

H2B1C
Histone H2B type 1-C/E/F/G/I

1

17

High-throughput

0.479

High

998728

H31
Histone H3.1

1

20

High-throughput

0.479

High

1026519

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1049706

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1106376

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

7

High-throughput

0.479

High

1114105

CUL3
Cullin-3

1

10

High-throughput

0.479

High

1137972

TNIP1
TNFAIP3-interacting protein 1

1

18

High-throughput

0.479

High

1255221

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1276698

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1324056

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.479

High

1338336

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1367106

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1391722

AURKB
Aurora kinase B

1

7

Small-scale

0.479

High

1403763

RMD3
Regulator of microtubule dynamics protein 3

1

2

High-throughput

0.479

High

1406252

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1406256

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

5

High-throughput

0.479

High

1406260

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1406261

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1406264

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.479

High

1406265

ANLN
Anillin

1

7

High-throughput

0.479

High

1406266

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

7

Small-scale

0.479

High

1406273

ZRAN1
Ubiquitin thioesterase ZRANB1

1

18

High-throughput

0.479

High

1406275

APC4
Anaphase-promoting complex subunit 4

1

3

Small-scale

0.479

High

1406282

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1293653

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1382166

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

1331355

ENAH
Protein enabled homolog

1

15

High-throughput

0.445

High

1406263

ZN287
Zinc finger protein 287

1

1

High-throughput

0.445

High

218677

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.437

High

389488

FINC
Fibronectin

1

2

High-throughput

0.437

High

768986

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

879389

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

1314381

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.437

High

1200949

SGO2
Shugoshin 2

1

0

Small-scale

0.426

High

1406267

IFT57
Intraflagellar transport protein 57 homolog

1

0

High-throughput

0.426

High

1406269

GRHL1
Grainyhead-like protein 1 homolog

1

0

High-throughput

0.426

High

887161

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

1162015

H31T
Histone H3.1t

1

20

Small-scale

0.408

High

619900

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.407

High

1156944

CNGA3
Cyclic nucleotide-gated channel alpha-3

1

1

High-throughput

0.407

High

1389680

SGF29
SAGA-associated factor 29

4

0

High-throughput

0.360

High

562755

BMP1
Bone morphogenetic protein 1

2

0

High-throughput

0.328

High

1334450

RELL2
RELT-like protein 2

2

0

High-throughput

0.328

High

1406253

KXDL1
KxDL motif-containing protein 1

2

0

High-throughput

0.313

High

1287528

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.279

Low

1340607

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

0

High-throughput

0.279

Low

1389733

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1405359

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.279

Low

124457

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025