HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.648

Property	Details
Experiments	18157088, 15802564, 31391242
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 353
+	Hs
		584950 SQSTM_HUMAN (1-440): 0: 760: 100.00		RO52_HUMAN (8-353): 2.82e-75: 241: 14.74
+	Hs
		1036807 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI11_HUMAN (8-353): 1.23e-72: 234: 17.63
+	Hs
		1036872 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		536812 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1019298 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI26_HUMAN (8-353): 7.66e-66: 219: 14.60
+	Hs
		1036876 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRIM5_HUMAN (10-346): 1.16e-64: 214: 17.49
+	Hs
		242847 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI13_HUMAN (14-286): 2.03e-64: 211: 25.90
+	Mm
		102616 SQSTM_MOUSE (1-440): 0: 731: 90.72		TRI55_MOUSE (11-324): 4.46e-73: 237: 61.47
+	Hs
		1036706 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI50_HUMAN (14-250): 3.59e-14: 75.1: 25.00
+	Hs
		1036682 SQSTM_HUMAN (1-440): 0: 760: 100.00		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		584963 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		RO52_HUMAN (8-353): 2.82e-75: 241: 14.74
+	Hs
		1170674 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		319890 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Mm
		1118130 HERC2_MOUSE (120-197): 2.07e-12: 71.7: 32.50		TRI67_MOUSE (75-147): 1.18e-11: 67.9: 28.21