Protein: DSC1
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)

Gene: DSC1
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q08554

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002160 - desmosome maintenance
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0005921 - gap junction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1036712

DSG1
Desmoglein-1

3

18

Small-scale

0.840

High

1064427

DSG2
Desmoglein-2

1

19

Small-scale

0.724

High

563682

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

High-throughput

0.628

High

1064485

PD1L1
Programmed cell death 1 ligand 1

1

13

High-throughput

0.618

High

587636

DESP
Desmoplakin

2

11

Small-scale

0.595

High

577728

PLAK
Junction plakoglobin

2

20

Small-scale

0.586

High

1064424

PKP1
Plakophilin-1

2

20

Small-scale

0.586

High

371866

MYC
Myc proto-oncogene protein

3

12

High-throughput

0.585

High

830624

CCNF
Cyclin-F

2

5

High-throughput

0.549

High

462867

LAMB1
Laminin subunit beta-1

1

4

High-throughput

0.536

High

838996

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.536

High

1064442

SO4C1
Solute carrier organic anion transporter family member 4C1

1

3

High-throughput

0.536

High

1064429

TNIP1
TNFAIP3-interacting protein 1

2

10

High-throughput

0.533

High

1064452

SLX4
Structure-specific endonuclease subunit SLX4

2

2

High-throughput

0.521

High

1064430

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

1064433

DDR2
Discoidin domain-containing receptor 2

1

20

High-throughput

0.500

High

247110

TBCD4
TBC1 domain family member 4

1

4

High-throughput

0.489

High

317166

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

High-throughput

0.489

High

484506

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

919912

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.489

High

1064421

MK07
Mitogen-activated protein kinase 7

1

5

High-throughput

0.489

High

1064434

CR021
UPF0711 protein C18orf21

1

2

High-throughput

0.489

High

1064444

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.489

High

1064448

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

1064458

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

7

High-throughput

0.489

High

1064459

GRK7
Rhodopsin kinase GRK7

1

3

High-throughput

0.489

High

1064461

ZDH19
Palmitoyltransferase ZDHHC19

1

6

High-throughput

0.489

High

1064480

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.489

High

1064473

PKP2
Plakophilin-2

1

20

Small-scale

0.481

High

1064490

PKP3
Plakophilin-3

1

20

Small-scale

0.481

High

141444

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

331857

GOSR1
Golgi SNAP receptor complex member 1

1

1

High-throughput

0.479

High

400714

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

411810

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

456707

ANXA2
Annexin A2

1

6

High-throughput

0.479

High

460809

CATB
Cathepsin B

1

3

Small-scale

0.479

High

537044

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

558071

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

671780

ZA2G
Zinc-alpha-2-glycoprotein

1

4

High-throughput

0.479

High

729545

CASPE
Caspase-14

1

2

High-throughput

0.479

High

755891

MCM5
DNA replication licensing factor MCM5

1

2

High-throughput

0.479

High

767182

MERL
Merlin

1

19

High-throughput

0.479

High

855602

CRK
Adapter molecule crk

1

15

High-throughput

0.479

High

908818

NEK2
Serine/threonine-protein kinase Nek2

1

9

Small-scale

0.479

High

990144

1433Z
14-3-3 protein zeta/delta

1

18

Small-scale

0.479

High

1026337

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

1047404

K1C17
Keratin, type I cytoskeletal 17

1

2

High-throughput

0.479

High

1062224

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.479

High

1064419

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.479

High

1064426

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

1064435

FILA2
Filaggrin-2

1

4

High-throughput

0.479

High

1064454

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1064463

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

High-throughput

0.479

High

1064464

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1064467

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

1064468

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.479

High

1064472

RANB9
Ran-binding protein 9

1

9

Small-scale

0.479

High

1064475

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1064477

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

1064478

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.479

High

1064481

S10AE
Protein S100-A14

1

4

High-throughput

0.479

High

1064482

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1064487

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

1064489

FND3A
Fibronectin type-III domain-containing protein 3A

1

20

High-throughput

0.479

High

1030443

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1064428

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1064431

CDSN
Corneodesmosin

1

0

High-throughput

0.458

High

1064436

DCA17
DDB1- and CUL4-associated factor 17

1

0

High-throughput

0.458

High

1064439

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1064470

SPB12
Serpin B12

1

0

High-throughput

0.458

High

1064471

GSDMA
Gasdermin-A

1

0

High-throughput

0.458

High

1064493

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.457

High

127064

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

942579

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.445

High

948804

CD81
CD81 antigen

1

4

High-throughput

0.445

High

1063746

LG3BP
Galectin-3-binding protein

1

9

High-throughput

0.445

High

1064437

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

293615

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

302498

RNF8
E3 ubiquitin-protein ligase RNF8

1

2

High-throughput

0.437

High

406105

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.437

High

413707

P53
Cellular tumor antigen p53

1

3

High-throughput

0.437

High

590892

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

655806

TBG1
Tubulin gamma-1 chain

1

4

High-throughput

0.437

High

667807

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.437

High

888009

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.437

High

964592

DCAF7
DDB1- and CUL4-associated factor 7

1

2

High-throughput

0.437

High

970401

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1004486

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

1035565

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.437

High

1046349

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.437

High

1047897

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.437

High

1064418

CDC20
Cell division cycle protein 20 homolog

1

3

High-throughput

0.437

High

1064422

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

1064423

CUL4A
Cullin-4A

1

9

High-throughput

0.437

High

1064425

DX39B
Spliceosome RNA helicase DDX39B

1

5

High-throughput

0.437

High

1064432

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.437

High

1064443

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1064445

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.437

High

1064446

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.437

High

1064447

ZCH18
Zinc finger CCCH domain-containing protein 18

1

4

High-throughput

0.437

High

1064455

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.437

High

1064456

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.437

High

1064462

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

3

High-throughput

0.437

High

1064465

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.437

High

1064466

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

5

Small-scale

0.437

High

1064476

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

1064479

PRD14
PR domain zinc finger protein 14

1

1

Small-scale

0.437

High

1064483

ANLN
Anillin

1

4

High-throughput

0.437

High

1064484

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.437

High

1064486

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1064451

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

911561

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.407

High

1064453

POC5
Centrosomal protein POC5

1

2

Small-scale

0.407

High

1064474

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.279

Low

423643

ARGI1
Arginase-1

1

0

High-throughput

0.249

Low

623303

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.249

Low

695298

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

1064420

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.249

Low

1064438

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.249

Low

1064440

KPLCE
Protein KPLCE

1

0

High-throughput

0.249

Low

1064441

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1064449

FBX11
F-box only protein 11

1

0

Small-scale

0.249

Low

1064450

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.249

Low

1064457

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.249

Low

1064460

STAG1
Cohesin subunit SA-1

1

0

High-throughput

0.249

Low

1064469

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1064488

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

1064491

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.249

Low

1064492

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1021

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

1064417

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025