HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 0.60 0.678

The method score is based on:

Property Details
Experiments 33545068, 31723608, 25026213
Identification Methods proximity labelling technology, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005776 - autophagosome
GO:0005829 - cytosol
GO:0006914 - autophagy
and 4 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 440
Hs

1 577
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024