Protein: DSG4
Desmoglein-4 (Cadherin family member 13)

Gene: DSG4
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q86SJ6

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0001942 - hair follicle development
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane
GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1286491

JAM1
Junctional adhesion molecule A

1

15

High-throughput

0.691

High

181904

SMAD9
Mothers against decapentaplegic homolog 9

3

4

High-throughput

0.667

High

1286468

O51E2
Olfactory receptor 51E2

3

0

High-throughput

0.638

High

406901

MAS
Proto-oncogene Mas

2

4

High-throughput

0.628

High

1286443

IL31R
Interleukin-31 receptor subunit alpha

2

16

High-throughput

0.628

High

853813

MK09
Mitogen-activated protein kinase 9

2

3

High-throughput

0.611

High

1286441

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

3

2

High-throughput

0.609

High

1286451

TFG
Protein TFG

3

2

High-throughput

0.609

High

1286444

GRP4
RAS guanyl-releasing protein 4

2

0

High-throughput

0.602

High

1286464

REEP2
Receptor expression-enhancing protein 2

2

0

High-throughput

0.602

High

190072

FOXP2
Forkhead box protein P2

2

2

High-throughput

0.574

High

418237

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

3

High-throughput

0.574

High

942445

GSC
Homeobox protein goosecoid

2

2

High-throughput

0.574

High

1165335

SYT16
Synaptotagmin-16

2

3

High-throughput

0.574

High

1225719

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

1

High-throughput

0.574

High

1286433

S22A9
Organic anion transporter 7

2

2

High-throughput

0.574

High

1286449

FAN
Protein FAN

2

2

High-throughput

0.574

High

1286455

RM38
Large ribosomal subunit protein mL38

2

1

High-throughput

0.574

High

1286483

FBXL4
F-box/LRR-repeat protein 4

2

3

High-throughput

0.574

High

1286485

OAZ3
Ornithine decarboxylase antizyme 3

2

1

High-throughput

0.574

High

1286489

KIF3A
Kinesin-like protein KIF3A

2

3

High-throughput

0.574

High

1155356

RB11B
Ras-related protein Rab-11B

2

9

High-throughput

0.558

High

1286435

ELMD1
ELMO domain-containing protein 1

2

1

High-throughput

0.558

High

301811

ANXA9
Annexin A9

1

7

High-throughput

0.536

High

366125

C1R
Complement C1r subcomponent

1

11

High-throughput

0.536

High

761252

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.536

High

988489

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.536

High

1036663

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

8

High-throughput

0.536

High

1087061

FSTL1
Follistatin-related protein 1

1

3

High-throughput

0.536

High

1102950

ITAD
Integrin alpha-D

1

6

High-throughput

0.536

High

1127551

SPRL1
SPARC-like protein 1

1

3

High-throughput

0.536

High

1235227

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

2

High-throughput

0.536

High

1286452

US6NL
USP6 N-terminal-like protein

1

4

High-throughput

0.536

High

1286463

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

2

High-throughput

0.536

High

1286469

SRMS
Tyrosine-protein kinase Srms

1

10

High-throughput

0.536

High

1286474

RAB9B
Ras-related protein Rab-9B

1

12

High-throughput

0.536

High

1286476

NPAP1
Nuclear pore-associated protein 1

1

7

High-throughput

0.536

High

762409

BTC
Probetacellulin [Cleaved into: Betacellulin

1

0

High-throughput

0.513

High

771635

DRD3
D(3) dopamine receptor

1

0

High-throughput

0.513

High

1286456

DTBP1
Dysbindin

1

0

High-throughput

0.513

High

1286473

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.513

High

1286488

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

49400

DHR12
Dehydrogenase/reductase SDR family member 12

1

6

High-throughput

0.489

High

133866

FOXN3
Forkhead box protein N3

1

2

High-throughput

0.489

High

326728

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.489

High

370714

FOS
Protein c-Fos

1

2

High-throughput

0.489

High

469508

SYPH
Synaptophysin

1

1

High-throughput

0.489

High

762465

PROF2
Profilin-2

1

1

High-throughput

0.489

High

866745

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.489

High

909065

NEK4
Serine/threonine-protein kinase Nek4

1

13

High-throughput

0.489

High

1138971

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

2

High-throughput

0.489

High

1203373

YIF1B
Protein YIF1B

1

1

High-throughput

0.489

High

1286429

CACL1
CDK2-associated and cullin domain-containing protein 1

1

8

High-throughput

0.489

High

1286431

TF2LX
Homeobox protein TGIF2LX

1

1

High-throughput

0.489

High

1286439

RDH13
Retinol dehydrogenase 13

1

6

High-throughput

0.489

High

1286442

BHE23
Class E basic helix-loop-helix protein 23

1

2

High-throughput

0.489

High

1286446

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.489

High

1286454

OTUL
Ubiquitin thioesterase otulin

1

2

High-throughput

0.489

High

1286459

ZN597
Zinc finger protein 597

1

1

High-throughput

0.489

High

1286484

PNMA2
Paraneoplastic antigen Ma2

1

2

High-throughput

0.489

High

1286486

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

6

High-throughput

0.489

High

520600

RARA
Retinoic acid receptor alpha

1

8

Small-scale

0.479

High

1286428

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.479

High

351919

S1PR4
Sphingosine 1-phosphate receptor 4

1

5

High-throughput

0.445

High

468546

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.445

High

906305

GPC3
Glypican-3

1

3

High-throughput

0.445

High

1286465

SYT11
Synaptotagmin-11

1

2

High-throughput

0.445

High

404173

GCR
Glucocorticoid receptor

1

9

High-throughput

0.437

High

660662

IF4B
Eukaryotic translation initiation factor 4B

1

2

Small-scale

0.437

High

1286450

ESR2
Estrogen receptor beta

1

8

High-throughput

0.437

High

1286467

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.437

High

733703

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

0

High-throughput

0.426

High

1286438

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.426

High

252773

AP180
Clathrin coat assembly protein AP180

1

4

High-throughput

0.407

High

952224

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.407

High

1286466

OSBL8
Oxysterol-binding protein-related protein 8

1

2

High-throughput

0.407

High

1286477

SLAF8
SLAM family member 8

1

15

High-throughput

0.407

High

292296

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

0

High-throughput

0.347

High

1200942

SGO2
Shugoshin 2

3

0

High-throughput

0.347

High

1211601

TEX35
Testis-expressed protein 35

3

0

High-throughput

0.347

High

1235460

IFIX
Pyrin and HIN domain-containing protein 1

3

0

High-throughput

0.347

High

1286432

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.347

High

1286453

PMM1
Phosphomannomutase 1

3

0

High-throughput

0.347

High

1286457

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

3

0

High-throughput

0.347

High

1286458

MTNB
Methylthioribulose-1-phosphate dehydratase

3

0

High-throughput

0.347

High

1286480

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.347

High

1081726

CF210
Cilia- and flagella- associated protein 210

2

0

High-throughput

0.328

High

1286447

CPLX3
Complexin-3

2

0

High-throughput

0.328

High

1286462

SETB2
Histone-lysine N-methyltransferase SETDB2

2

0

High-throughput

0.328

High

1286471

ZMAT4
Zinc finger matrin-type protein 4

2

0

High-throughput

0.328

High

1093474

COASY
Bifunctional coenzyme A synthase

2

0

High-throughput

0.318

High

252943

UD19
UDP-glucuronosyltransferase 1A9

1

0

High-throughput

0.279

Low

284171

SRS10
Serine/arginine-rich splicing factor 10

1

0

High-throughput

0.279

Low

755496

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

876359

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

881719

FNTB
Protein farnesyltransferase subunit beta

1

0

High-throughput

0.279

Low

1206193

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1250866

HEPN1
Putative cancer susceptibility gene HEPN1 protein

1

0

High-throughput

0.279

Low

1273949

DYM
Dymeclin

1

0

High-throughput

0.279

Low

1286427

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1286430

DOPP1
Dolichyldiphosphatase 1

1

0

High-throughput

0.279

Low

1286434

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.279

Low

1286436

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

1286437

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

1286440

TM35B
Transmembrane protein 35B

1

0

High-throughput

0.279

Low

1286445

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.279

Low

1286448

SKA2
Spindle and kinetochore-associated protein 2

1

0

High-throughput

0.279

Low

1286461

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1286470

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.279

Low

1286472

POPD2
Popeye domain-containing protein 2

1

0

High-throughput

0.279

Low

1286478

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1286479

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

1286481

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.279

Low

1286482

FBX3
F-box only protein 3

1

0

High-throughput

0.279

Low

1286487

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

1286490

MTL5
Tesmin

1

0

High-throughput

0.279

Low

528472

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.232

Low

1207707

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low

1286460

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.232

Low

1286475

SPNXC
Sperm protein associated with the nucleus on the X chromosome C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025