Protein: CP51A
Lanosterol 14-alpha demethylase (LDM) (EC 1.14.14.154) (CYPLI) (Cytochrome P450 51A1) (CYP51A1) (Cytochrome P450-14DM) (Cytochrome P45014DM) (Cytochrome P450LI) (Sterol 14-alpha demethylase)

Gene: CP51A, CYP51A1
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q16850

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005789 - endoplasmic reticulum membrane
GO:0006694 - steroid biosynthetic process
GO:0006695 - cholesterol biosynthetic process
GO:0006699 - bile acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

513740

CP19A
Aromatase

1

11

High-throughput

0.691

High

199899

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.638

High

474815

POTEI
POTE ankyrin domain family member I

3

0

High-throughput

0.638

High

1088316

PCDGG
Protocadherin gamma-B4

2

5

High-throughput

0.628

High

349353

RASH
GTPase HRas

2

2

High-throughput

0.611

High

1088321

PCDA3
Protocadherin alpha-3

2

2

High-throughput

0.574

High

123613

PGRC1
Membrane-associated progesterone receptor component 1

1

8

High-throughput

0.536

High

558730

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

1

High-throughput

0.536

High

834292

PSN1
Presenilin-1

1

2

High-throughput

0.536

High

1015978

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

3

High-throughput

0.536

High

1053756

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

1088260

PTHD3
Patched domain-containing protein 3

1

3

High-throughput

0.536

High

1088262

ACTBL
Beta-actin-like protein 2

1

1

High-throughput

0.536

High

1088289

T4S18
Transmembrane 4 L6 family member 18

1

1

High-throughput

0.536

High

1088292

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.536

High

1088309

RTN4
Reticulon-4

1

5

High-throughput

0.536

High

1088311

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.536

High

1088318

PCDB3
Protocadherin beta-3

1

5

High-throughput

0.536

High

227600

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.533

High

168256

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.513

High

235375

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.513

High

351158

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

654378

CALX
Calnexin

1

0

High-throughput

0.513

High

725461

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.513

High

1088266

TM268
Transmembrane protein 268

1

0

High-throughput

0.513

High

1088286

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.513

High

1088287

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1088297

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

1088305

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1088283

ZN420
Zinc finger protein 420

1

1

High-throughput

0.494

High

201093

AQP9
Aquaporin-9

1

7

High-throughput

0.489

High

234013

O10H2
Olfactory receptor 10H2

1

2

High-throughput

0.489

High

537744

INSRR
Insulin receptor-related protein

1

5

High-throughput

0.489

High

676804

SSR1
Somatostatin receptor type 1

1

2

High-throughput

0.489

High

1088263

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.489

High

1088293

NEB2
Neurabin-2

1

3

High-throughput

0.489

High

1088296

KCNS3
Potassium voltage-gated channel subfamily S member 3

1

1

High-throughput

0.489

High

1088300

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.489

High

1088307

RXFP1
Relaxin receptor 1

1

1

High-throughput

0.489

High

1088308

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

1088317

O10H1
Olfactory receptor 10H1

1

2

High-throughput

0.489

High

1088319

PCDGL
Protocadherin gamma-C4

1

5

High-throughput

0.489

High

1088320

PCDGH
Protocadherin gamma-B5

1

5

High-throughput

0.489

High

1088323

SNX14
Sorting nexin-14

1

2

High-throughput

0.489

High

163823

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

167931

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

348691

RASN
GTPase NRas

1

2

High-throughput

0.479

High

350204

RASK
GTPase KRas

1

2

High-throughput

0.479

High

377362

GCR
Glucocorticoid receptor

1

2

Small-scale

0.479

High

436330

RHOC
Rho-related GTP-binding protein RhoC

1

1

High-throughput

0.479

High

793103

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

1

High-throughput

0.479

High

885923

EVA1C
Protein eva-1 homolog C

1

1

High-throughput

0.479

High

900521

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1088274

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.479

High

1088280

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1088291

RN185
E3 ubiquitin-protein ligase RNF185

1

1

Small-scale

0.479

High

1088298

DERL1
Derlin-1

1

1

High-throughput

0.479

High

1088303

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.479

High

1088304

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

3

High-throughput

0.479

High

390922

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

739988

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

838863

EMD
Emerin

1

0

High-throughput

0.458

High

890174

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1087947

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

0

High-throughput

0.458

High

1088261

MBRL
Membralin

1

0

Small-scale

0.458

High

1088267

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1088275

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1088306

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1088322

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.458

High

120462

RHOD
Rho-related GTP-binding protein RhoD

1

2

High-throughput

0.437

High

205448

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

374305

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.437

High

433373

YES
Tyrosine-protein kinase Yes

1

5

High-throughput

0.437

High

542018

ETS1
Protein C-ets-1

1

1

High-throughput

0.437

High

575463

EGR1
Early growth response protein 1

1

3

High-throughput

0.437

High

844952

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.437

High

940971

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

969737

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.437

High

1088268

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1088269

PAQR9
Membrane progestin receptor epsilon

1

2

Small-scale

0.437

High

1088272

PAQR2
Adiponectin receptor protein 2

1

3

Small-scale

0.437

High

1088279

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

1088302

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.437

High

1088264

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1057485

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.407

High

1088290

TSN17
Tetraspanin-17

3

0

High-throughput

0.347

High

1088265

TRML2
Trem-like transcript 2 protein

2

0

High-throughput

0.318

High

1088281

CCNY
Cyclin-Y

2

0

High-throughput

0.318

High

1088294

KCNKG
Potassium channel subfamily K member 16

2

0

High-throughput

0.318

High

1088295

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.318

High

1088301

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.282

High

49454

CLRN2
Clarin-2

1

0

High-throughput

0.279

Low

179183

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

200577

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.279

Low

656364

DMB
HLA class II histocompatibility antigen, DM beta chain

1

0

High-throughput

0.279

Low

1051870

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.279

Low

1088270

T150A
Transmembrane protein 150A

1

0

High-throughput

0.279

Low

1088276

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1088277

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

1088278

I22R1
Interleukin-22 receptor subunit alpha-1

1

0

High-throughput

0.279

Low

1088282

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1088284

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.279

Low

1088313

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

0

High-throughput

0.279

Low

1088314

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.279

Low

61234

5HT3E
5-hydroxytryptamine receptor 3E

1

0

High-throughput

0.249

Low

346919

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

532545

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.249

Low

552848

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651338

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720588

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

779507

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

1079742

EREP1
Endosomal transmembrane epsin interactor 1

1

0

High-throughput

0.249

Low

1088271

LBN
Limbin

1

0

High-throughput

0.249

Low

1088273

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1088285

MCLN3
Mucolipin-3

1

0

High-throughput

0.249

Low

1088288

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1088310

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1088312

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

1088315

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.249

Low

1088299

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.213

Low


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Last updated: 15 Jul 2024