HitPredict

Interactor 1: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Interactor 2: SRRM2 (Q9UQ35)
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)
Gene: SRRM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1007 Hs			1 2752
+	Hs
		1348702 CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		1268608 DYRK2_HUMAN (565-1007): 1.72e-117: 375: 27.07		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		625642 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		833993 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		SRRM2_HUMAN (1-2752): 2.88e-178: 615: 100.00
+	Hs
		807687 CDK3_HUMAN (684-1004): 2.74e-128: 392: 26.91		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		415030 CDK1_HUMAN (684-1005): 4.59e-124: 381: 25.00		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		1301016 DYR1B_HUMAN (618-1005): 4.81e-119: 380: 30.25		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		820911 PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00		PRC2A_HUMAN (8-1230): 6.75e-14: 80.5: 10.65
+	Hs
		1268591 DYRK2_HUMAN (565-1007): 1.72e-117: 375: 27.07		TARA_HUMAN (1540-2752): 1.5e-31: 138: 11.50
+	Hs
		1264773 DYRK2_HUMAN (565-1007): 1.72e-117: 375: 27.07		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		625528 CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45		TITIN_HUMAN (26-1299): 8.38e-20: 100: 7.11
+	Hs
		807717 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		MAP1B_HUMAN (15-1517): 8.71e-69: 261: 10.13
+	Hs
		1043850 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		PRC2B_HUMAN (640-2750): 5.74e-64: 245: 9.36
+	Hs
		1044076 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		CIC_HUMAN (216-2751): 1.9e-62: 240: 8.98
+	Hs
		944676 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		MAP1A_HUMAN (170-2540): 2.1e-44: 181: 9.15
+	Hs
		1044147 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		TARA_HUMAN (1540-2752): 1.5e-31: 138: 11.50
+	Ce
		246633 MBK2_CAEEL (668-1007): 1.65e-37: 154: 30.37		O61201_CAEEL (520-2145): 3.23e-14: 81.8: 12.70
+	Hs
		311795 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		TACC2_HUMAN (1893-2744): 4.03e-13: 78.2: 8.34
+	Hs
		70875 CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05		B2RWP4_HUMAN (1893-2744): 4.01e-13: 78.2: 8.34
+	Hs
		152642 DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65		KMT2D_HUMAN (10-501): 7.91e-09: 63.9: 11.75