Protein: NGN3
Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)

Gene: NGN3, NEUROG3
Organism: Homo sapiens
Interactions: 154
UniProt ID: Q9Y4Z2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1403959

HTF4
Transcription factor 12

8

20

High-throughput

0.974

High

587269

ITF2
Transcription factor 4

5

20

High-throughput

0.924

High

587542

TFE2
Transcription factor E2-alpha

3

20

High-throughput

0.855

High

868657

ID4
DNA-binding protein inhibitor ID-4

2

20

High-throughput

0.811

High

1393916

HES6
Transcription cofactor HES-6

2

19

High-throughput

0.811

High

1008007

PO6F2
POU domain, class 6, transcription factor 2

2

2

High-throughput

0.783

High

1273922

BHA15
Class A basic helix-loop-helix protein 15

1

19

High-throughput

0.691

High

1058379

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

4

4

Small-scale

0.691

High

1394388

ZN496
Zinc finger protein 496

3

4

High-throughput

0.662

High

316217

RECQ4
ATP-dependent DNA helicase Q4

2

4

High-throughput

0.628

High

644158

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

High-throughput

0.628

High

940205

RRP1
Ribosomal RNA processing protein 1 homolog A

2

1

High-throughput

0.628

High

1134094

ZN638
Zinc finger protein 638

2

1

High-throughput

0.628

High

1309386

ARI3B
AT-rich interactive domain-containing protein 3B

2

5

High-throughput

0.628

High

1315306

ZN100
Zinc finger protein 100

2

3

High-throughput

0.628

High

1316904

ASPM
Abnormal spindle-like microcephaly-associated protein

2

11

High-throughput

0.628

High

1332647

ZN579
Zinc finger protein 579

2

2

High-throughput

0.628

High

1403836

RMD3
Regulator of microtubule dynamics protein 3

2

1

High-throughput

0.628

High

1436189

YYAP1
YY1-associated protein 1

2

1

High-throughput

0.628

High

1436256

ZN430
Zinc finger protein 430

2

3

High-throughput

0.628

High

1491472

NGN3
Neurogenin-3

1

18

Small-scale

0.618

High

1066209

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

2

1

Small-scale

0.611

High

213346

ADCY6
Adenylate cyclase type 6

3

1

High-throughput

0.604

High

1212734

TMTC4
Protein O-mannosyl-transferase TMTC4

3

2

High-throughput

0.604

High

138409

ZN593
Zinc finger protein 593

2

0

High-throughput

0.602

High

340713

NET1
Netrin-1

2

0

High-throughput

0.602

High

1275989

SETX
Probable helicase senataxin

2

0

High-throughput

0.602

High

1452004

TEX10
Testis-expressed protein 10

2

0

High-throughput

0.602

High

1453085

RTEL1
Regulator of telomere elongation helicase 1

2

0

High-throughput

0.602

High

1131864

LBR
Delta(14)-sterol reductase LBR

2

3

High-throughput

0.601

High

1214691

RBM26
RNA-binding protein 26

2

3

High-throughput

0.601

High

141189

NOP56
Nucleolar protein 56

2

1

High-throughput

0.574

High

1106249

MYO9B
Unconventional myosin-IXb

2

1

High-throughput

0.574

High

1153238

HERC1
Probable E3 ubiquitin-protein ligase HERC1

2

4

High-throughput

0.574

High

1240525

DHX57
Putative ATP-dependent RNA helicase DHX57

2

1

High-throughput

0.574

High

1383757

EME1
Structure-specific endonuclease subunit EME1

2

1

High-throughput

0.574

High

1397772

RMD2
Regulator of microtubule dynamics protein 2

2

1

High-throughput

0.574

High

1408454

TEP1
Telomerase protein component 1

2

2

High-throughput

0.574

High

1049070

REL
Proto-oncogene c-Rel

1

6

High-throughput

0.573

High

369109

ASSY
Argininosuccinate synthase

2

1

High-throughput

0.549

High

644240

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

1

High-throughput

0.536

High

877265

KC1D
Casein kinase I isoform delta

1

3

High-throughput

0.536

High

1040410

DYST
Dystonin

1

11

High-throughput

0.536

High

1243886

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.536

High

1253889

SRCAP
Helicase SRCAP

1

12

High-throughput

0.536

High

1316607

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

11

High-throughput

0.536

High

1330583

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

High-throughput

0.536

High

1331058

DDX51
ATP-dependent RNA helicase DDX51

1

2

High-throughput

0.536

High

1356522

PHF10
PHD finger protein 10

1

7

High-throughput

0.536

High

1395497

ZFP91
E3 ubiquitin-protein ligase ZFP91

1

4

High-throughput

0.536

High

1398182

HEXI2
Protein HEXIM2

1

3

High-throughput

0.536

High

1452376

DDX56
Probable ATP-dependent RNA helicase DDX56

1

3

High-throughput

0.536

High

1454730

RBM27
RNA-binding protein 27

1

3

High-throughput

0.536

High

1462299

MAGD2
Melanoma-associated antigen D2

1

3

High-throughput

0.536

High

1462366

FAF1
FAS-associated factor 1

1

2

High-throughput

0.536

High

1490997

ZN281
Zinc finger protein 281

1

3

High-throughput

0.536

High

1491474

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

2

High-throughput

0.536

High

1211370

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.513

High

1240731

CDC73
Parafibromin

1

0

High-throughput

0.513

High

1295002

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

High-throughput

0.513

High

1353805

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

1411233

TIRR
Tudor-interacting repair regulator protein

1

0

High-throughput

0.513

High

1446865

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

High-throughput

0.513

High

1448093

SPHK2
Sphingosine kinase 2

1

0

High-throughput

0.513

High

1491456

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.513

High

74075

MYO9A
Unconventional myosin-IXa

1

1

High-throughput

0.489

High

252207

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.489

High

348235

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

2

High-throughput

0.489

High

1214840

ATD3B
ATPase family AAA domain-containing protein 3B

1

2

High-throughput

0.489

High

1219769

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

1251479

GGYF2
GRB10-interacting GYF protein 2

1

4

High-throughput

0.489

High

1272635

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

1

High-throughput

0.489

High

1281681

ZER1
Protein zer-1 homolog

1

1

High-throughput

0.489

High

1327297

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.489

High

1350819

RS4Y2
Small ribosomal subunit protein eS4, Y isoform 2

1

1

High-throughput

0.489

High

1390325

TRI11
E3 ubiquitin-protein ligase TRIM11

1

3

High-throughput

0.489

High

1409973

DDX50
ATP-dependent RNA helicase DDX50

1

1

High-throughput

0.489

High

1421076

ZY11B
Protein zyg-11 homolog B

1

1

High-throughput

0.489

High

1438611

MRM3
rRNA methyltransferase 3, mitochondrial

1

1

High-throughput

0.489

High

1446694

LUC7L
Putative RNA-binding protein Luc7-like 1

1

2

High-throughput

0.489

High

1491473

TF3C3
General transcription factor 3C polypeptide 3

1

5

High-throughput

0.489

High

123888

MYO1C
Unconventional myosin-Ic

1

3

Small-scale

0.479

High

425084

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

538171

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

552456

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.479

High

658492

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.479

High

660197

COF1
Cofilin-1

1

1

Small-scale

0.479

High

842049

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

Small-scale

0.479

High

997579

TBB4B
Tubulin beta-4B chain

1

2

Small-scale

0.479

High

1028920

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

10

Small-scale

0.479

High

1040247

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

4

Small-scale

0.479

High

1068345

AHNK
Neuroblast differentiation-associated protein AHNAK

1

2

Small-scale

0.479

High

1280638

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.479

High

1371805

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.479

High

1410794

MBB1A
Myb-binding protein 1A

1

1

Small-scale

0.479

High

586970

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.458

High

694098

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

773314

MYH10
Myosin-10

1

0

Small-scale

0.458

High

948492

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

Small-scale

0.458

High

949524

NANO3
Nanos homolog 3

1

0

Small-scale

0.458

High

969539

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

973008

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

1153524

SPEG
Striated muscle preferentially expressed protein kinase

1

0

Small-scale

0.458

High

1022207

DAB2
Disabled homolog 2

1

1

High-throughput

0.445

High

1187993

GON4L
GON-4-like protein

1

1

High-throughput

0.445

High

1211875

CHCH9
Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial

1

2

High-throughput

0.445

High

1287707

RBM23
Probable RNA-binding protein 23

1

3

High-throughput

0.445

High

228008

MYO1B
Unconventional myosin-Ib

1

4

Small-scale

0.437

High

533105

CH60
60 kDa heat shock protein, mitochondrial

1

1

Small-scale

0.437

High

773701

COPB2
Coatomer subunit beta'

1

3

Small-scale

0.437

High

952681

MYL6
Myosin light polypeptide 6

1

1

Small-scale

0.437

High

970198

RS16
Small ribosomal subunit protein uS9

1

2

Small-scale

0.437

High

1024503

S25A3
Solute carrier family 25 member 3

1

3

Small-scale

0.437

High

1117538

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

Small-scale

0.437

High

1143320

PLEC
Plectin

1

8

Small-scale

0.437

High

1247541

POTEE
POTE ankyrin domain family member E

1

5

Small-scale

0.437

High

1290007

LUZP1
Leucine zipper protein 1

1

3

Small-scale

0.437

High

1365800

GCN1
Stalled ribosome sensor GCN1

1

1

Small-scale

0.437

High

1450618

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

Small-scale

0.437

High

1461772

COR1C
Coronin-1C

1

3

Small-scale

0.437

High

1462486

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

11

Small-scale

0.437

High

1311328

CDAN1
Codanin-1

1

0

High-throughput

0.426

High

318421

MYO1D
Unconventional myosin-Id

1

3

High-throughput

0.407

High

1090326

ELAV2
ELAV-like protein 2

1

1

High-throughput

0.407

High

1339441

NBEA
Neurobeachin

1

1

High-throughput

0.407

High

1386849

KCD12
BTB/POZ domain-containing protein KCTD12

1

1

High-throughput

0.407

High

49603

GXLT2
Glucoside xylosyltransferase 2

3

0

High-throughput

0.345

High

1357622

DCAF4
DDB1- and CUL4-associated factor 4

3

0

High-throughput

0.345

High

1434799

DHX35
Probable ATP-dependent RNA helicase DHX35

3

0

High-throughput

0.345

High

1332327

CC71L
Coiled-coil domain-containing protein 71L

2

0

High-throughput

0.328

High

1356468

TF3C2
General transcription factor 3C polypeptide 2

2

0

High-throughput

0.328

High

1085861

TF3C1
General transcription factor 3C polypeptide 1

2

0

Small-scale

0.318

High

1313236

PLPL6
Patatin-like phospholipase domain-containing protein 6

2

0

Small-scale

0.318

High

1203922

NOM1
Nucleolar MIF4G domain-containing protein 1

2

0

High-throughput

0.313

High

194857

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.279

Low

337846

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

562823

CY24A
Cytochrome b-245 light chain

1

0

High-throughput

0.279

Low

867835

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.279

Low

877408

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.279

Low

885614

PRI2
DNA primase large subunit

1

0

High-throughput

0.279

Low

1116934

MOGS
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.279

Low

1123288

DPYL3
Dihydropyrimidinase-related protein 3

1

0

High-throughput

0.279

Low

1335476

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.279

Low

1449415

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.279

Low

1452026

TOR4A
Torsin-4A

1

0

High-throughput

0.279

Low

1459061

ADDG
Gamma-adducin

1

0

High-throughput

0.279

Low

860653

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.249

Low

973109

RS29
Small ribosomal subunit protein uS14

1

0

Small-scale

0.249

Low

986295

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.249

Low

1098540

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

0

Small-scale

0.249

Low

1180638

KIF4B
Chromosome-associated kinesin KIF4B

1

0

Small-scale

0.249

Low

1311430

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

Small-scale

0.249

Low

1385542

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025