Interactor 1: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.975

The method score is based on:

Property Details
Experiments 25416956, 27045108, 32296183, 31980649, 15001576, 23473668, unassigned1304, 14743216, 22817896
Identification Methods two hybrid, enzymatic study, affinity chromatography technology, two hybrid array, protein kinase assay, validated two hybrid, two hybrid prey pooling approach, tandem affinity purification, molecular sieving, electron microscopy and 2 others

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Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005123 - death receptor binding
and 62 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 671
Hs

1 671
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Last updated: 15 Jul 2024