HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: TGIF1 (Q15583)
Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)
Gene: TGIF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	10995736, 11427533, 11226163
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005654 - nucleoplasm GO:0010629 - negative regulation of gene expression
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 401
+	Hs
		773070 HDAC1_HUMAN (1-482): 0: 668: 100.00		PBX1_HUMAN (112-360): 1.6e-45: 164: 15.94
+	Hs
		1038509 HDAC1_HUMAN (1-482): 0: 668: 100.00		TF2LX_HUMAN (119-398): 7.44e-43: 151: 30.53
+	Hs
		1038693 HDAC1_HUMAN (1-482): 0: 668: 100.00		TGIF2_HUMAN (163-398): 3.16e-42: 150: 50.21
+	Hs
		1216204 HDAC2_HUMAN (1-478): 0: 666: 85.92		TF2LX_HUMAN (119-398): 7.44e-43: 151: 30.53
+	Hs
		1038519 HDAC1_HUMAN (1-482): 0: 668: 100.00		MKX_HUMAN (145-376): 5.35e-39: 144: 22.03
+	Hs
		177218 HDAC3_HUMAN (9-434): 0: 574: 57.94		PBX1_HUMAN (112-360): 1.6e-45: 164: 15.94