HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: HELLS (Q9NRZ9)
Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6)
Gene: HELLS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	19561196, 17967891
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006346 - DNA methylation-dependent heterochromatin formation GO:2001243 - negative regulation of intrinsic apoptotic signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 838
+	Hs
		1270466 HDAC2_HUMAN (1-478): 0: 666: 85.92		HELLS_HUMAN (1-838): 0: 763: 100.00
+	Hs
		1018465 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Hs
		1018617 HDAC2_HUMAN (1-478): 0: 666: 85.92		CHD3_HUMAN (50-828): 0: 649: 24.79
+	Mm
		140261 HDAC1_MOUSE (1-482): 0: 672: 99.38		SMCA4_MOUSE (9-838): 0: 636: 25.42
+	Hs
		1038730 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD8_HUMAN (2-836): 0: 635: 26.71
+	Mm
		140286 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD4_MOUSE (51-828): 0: 629: 25.39
+	Hs
		846962 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Mm
		936385 HDAC2_MOUSE (1-478): 0: 664: 85.71		SMCA4_MOUSE (9-838): 0: 636: 25.42
+	Hs
		847037 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMCA4_HUMAN (9-838): 0: 633: 24.89
+	Hs
		1038382 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		1059770 HDAC2_HUMAN (1-478): 0: 666: 85.92		CHD4_HUMAN (51-828): 0: 630: 25.39
+	Hs
		1038563 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Hs
		1255037 HDAC2_HUMAN (1-478): 0: 666: 85.92		CHD5_HUMAN (50-835): 0: 627: 24.83
+	Mm
		56897 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD5_MOUSE (50-835): 0: 618: 25.17
+	Mm
		56900 HDAC2_MOUSE (1-478): 0: 664: 85.71		CHD5_MOUSE (50-835): 0: 618: 25.17
+	Hs
		229453 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMCA5_HUMAN (75-833): 0: 607: 30.76
+	Hs
		846768 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		846833 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMCA2_HUMAN (27-838): 0: 584: 26.37
+	Hs
		1038710 HDAC1_HUMAN (1-482): 0: 668: 100.00		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59
+	Hs
		1270443 HDAC2_HUMAN (1-478): 0: 666: 85.92		SMRCD_HUMAN (206-744): 1.53e-92: 315: 37.59