Protein: PUM2
Pumilio homolog 2 (Pumilio-2)

Gene: PUM2
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q8TB72

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001942 - hair follicle development
GO:0003723 - RNA binding
GO:0003730 - mRNA 3'-UTR binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1348099

PUM2
Pumilio homolog 2

2

7

Small-scale

0.757

High

1348101

NANO1
Nanos homolog 1

1

4

Small-scale

0.713

High

211371

RFOX2
RNA binding protein fox-1 homolog 2

3

10

High-throughput

0.667

High

1089480

ILF2
Interleukin enhancer-binding factor 2

3

4

High-throughput

0.667

High

1090262

ELAV2
ELAV-like protein 2

3

10

High-throughput

0.662

High

1348107

DAZL
Deleted in azoospermia-like

3

11

Small-scale

0.637

High

1330003

CELF5
CUGBP Elav-like family member 5

2

9

High-throughput

0.628

High

1348113

STRBP
Spermatid perinuclear RNA-binding protein

2

10

High-throughput

0.628

High

949518

NANO3
Nanos homolog 3

1

4

Small-scale

0.618

High

1129460

PUM1
Pumilio homolog 1

1

6

High-throughput

0.618

High

48032

RBM47
RNA-binding protein 47

2

9

High-throughput

0.611

High

1324441

CLASR
CLK4-associating serine/arginine rich protein

2

2

High-throughput

0.574

High

1348115

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

2

1

High-throughput

0.574

High

1348132

DAZ1
Deleted in azoospermia protein 1

1

12

Small-scale

0.573

High

396565

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

765727

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.571

High

170246

AURKA
Aurora kinase A

1

2

Small-scale

0.561

High

192616

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

214318

MSI1H
RNA-binding protein Musashi homolog 1

1

10

High-throughput

0.536

High

256649

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

7

High-throughput

0.536

High

344256

PTBP3
Polypyrimidine tract-binding protein 3

1

5

High-throughput

0.536

High

462530

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

High-throughput

0.536

High

504748

FBSP1
F-box/SPRY domain-containing protein 1

1

6

High-throughput

0.536

High

700693

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.536

High

1095075

DAZ2
Deleted in azoospermia protein 2

1

13

High-throughput

0.536

High

1148737

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

12

High-throughput

0.536

High

1277865

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.536

High

1307496

RBM45
RNA-binding protein 45

1

14

High-throughput

0.536

High

1314823

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

6

High-throughput

0.536

High

1348103

LAR4B
La-related protein 4B

1

5

High-throughput

0.536

High

1348109

SPSB4
SPRY domain-containing SOCS box protein 4

1

7

High-throughput

0.536

High

1348110

PABP5
Polyadenylate-binding protein 5

1

6

High-throughput

0.536

High

1348124

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

1

High-throughput

0.536

High

1348127

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.536

High

1348136

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

3

High-throughput

0.536

High

1348139

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1348141

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

2

High-throughput

0.536

High

1348146

YBOX2
Y-box-binding protein 2

1

4

High-throughput

0.536

High

1348117

RTP3
Receptor-transporting protein 3

1

0

High-throughput

0.513

High

1348118

PSMG3
Proteasome assembly chaperone 3

1

0

High-throughput

0.513

High

1332289

BOLL
Protein boule-like

1

11

Small-scale

0.506

High

1348108

CSN5
COP9 signalosome complex subunit 5

1

5

Small-scale

0.501

High

338914

CBX6
Chromobox protein homolog 6

1

2

High-throughput

0.489

High

1247609

SAMD1
Sterile alpha motif domain-containing protein 1

1

3

High-throughput

0.489

High

1348112

LOXL4
Lysyl oxidase homolog 4

1

1

High-throughput

0.489

High

1348142

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.489

High

180878

TIF1A
Transcription intermediary factor 1-alpha

1

6

Small-scale

0.479

High

242352

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

274202

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.479

High

341629

EYA4
Protein phosphatase EYA4

1

3

High-throughput

0.479

High

346095

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

8

High-throughput

0.479

High

372644

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

412295

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

472910

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

550371

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.479

High

606930

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

688282

TTP
mRNA decay activator protein ZFP36

1

4

High-throughput

0.479

High

713819

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

14

High-throughput

0.479

High

875724

PRC2A
Protein PRRC2A

1

6

High-throughput

0.479

High

984208

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

1032370

OTUD4
OTU domain-containing protein 4

1

3

High-throughput

0.479

High

1056867

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.479

High

1100912

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

1113772

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1122114

UBP2L
Ubiquitin-associated protein 2-like

1

4

High-throughput

0.479

High

1127023

RBM39
RNA-binding protein 39

1

8

High-throughput

0.479

High

1165475

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

13

High-throughput

0.479

High

1206497

PRC2B
Protein PRRC2B

1

6

High-throughput

0.479

High

1221005

FBW10
F-box/WD repeat-containing protein 10

1

6

High-throughput

0.479

High

1252342

MEX3B
RNA-binding protein MEX3B

1

3

High-throughput

0.479

High

1254747

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1280699

YTHD3
YTH domain-containing family protein 3

1

6

High-throughput

0.479

High

1310608

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

2

High-throughput

0.479

High

1316418

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

1322597

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

1336252

LS14A
Protein LSM14 homolog A

1

2

High-throughput

0.479

High

1339101

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1348100

SMAP2
Stromal membrane-associated protein 2

1

1

High-throughput

0.479

High

1348102

CNOT9
CCR4-NOT transcription complex subunit 9

1

5

High-throughput

0.479

High

1348104

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1348106

CELF1
CUGBP Elav-like family member 1

1

10

High-throughput

0.479

High

1348111

FUBP3
Far upstream element-binding protein 3

1

7

High-throughput

0.479

High

1348116

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

2

High-throughput

0.479

High

1348120

YTHD1
YTH domain-containing family protein 1

1

6

High-throughput

0.479

High

1348121

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

9

High-throughput

0.479

High

1348122

UNK
RING finger protein unkempt homolog

1

5

High-throughput

0.479

High

1348123

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

4

High-throughput

0.479

High

1348126

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1348128

MOV10
Helicase MOV-10

1

4

High-throughput

0.479

High

1348134

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

1348135

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

3

High-throughput

0.479

High

1348137

CNOT2
CCR4-NOT transcription complex subunit 2

1

8

High-throughput

0.479

High

1348138

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1348143

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

4

High-throughput

0.479

High

1348145

R3HD2
R3H domain-containing protein 2

1

5

High-throughput

0.479

High

1348147

YTHD2
YTH domain-containing family protein 2

1

6

High-throughput

0.479

High

1348149

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

8

High-throughput

0.479

High

1045550

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1135745

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1289472

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1348114

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

1348133

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

485284

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.445

High

1009261

PRR3
Proline-rich protein 3

1

1

High-throughput

0.445

High

1348119

MCRI2
MAPK regulated corepressor interacting protein 2

1

2

High-throughput

0.445

High

1348144

DICER
Endoribonuclease Dicer

1

2

Small-scale

0.445

High

143131

NFIB
Nuclear factor 1 B-type

1

5

High-throughput

0.437

High

194277

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.437

High

589221

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

657639

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.437

High

696004

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

879289

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1133546

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.437

High

1233921

Q6ICH2
single-stranded DNA cytosine deaminase

1

3

High-throughput

0.437

High

1336195

RN214
RING finger protein 214

1

2

High-throughput

0.437

High

1348105

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1348130

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

4

High-throughput

0.437

High

1111128

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1136748

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.426

High

1199608

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1348125

ATG5
Autophagy protein 5

1

0

High-throughput

0.426

High

1348140

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

Small-scale

0.417

High

73428

B2CML4
single-stranded DNA cytosine deaminase

1

3

High-throughput

0.407

High

868369

CDX1
Homeobox protein CDX-1

2

0

High-throughput

0.328

High

1340006

O13C3
Olfactory receptor 13C3

1

0

High-throughput

0.279

Low

1348148

BACE2
Beta-secretase 2

1

0

High-throughput

0.279

Low

1348131

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.251

Low

1348129

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025