HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: DNM3B (Q9UBC3)
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
Gene: DNMT3B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	16331260, 15148359, 15120635, 23708667
Identification Methods	pull down, biochemical, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010628 - positive regulation of gene expression
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 482 Hs			1 853
+	Hs
		1270494 HDAC2_HUMAN (1-478): 0: 666: 85.92		DNM3B_HUMAN (1-853): 0: 1352: 100.00
+	Rn
		100231 F7ENH8_RAT (1-478): 0: 664: 85.51		Q1LZ51_RAT (1-853): 0: 1270: 82.16
+	Hs
		1038858 HDAC1_HUMAN (1-482): 0: 668: 100.00		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Hs
		1038796 HDAC1_HUMAN (1-482): 0: 668: 100.00		DNM3L_HUMAN (417-758): 2.76e-164: 484: 36.81
+	Hs
		1038468 HDAC1_HUMAN (1-482): 0: 668: 100.00		PWP2B_HUMAN (15-310): 4.83e-94: 309: 25.32
+	Hs
		1038633 HDAC1_HUMAN (1-482): 0: 668: 100.00		PWP2A_HUMAN (45-310): 1.4e-63: 230: 19.50
+	Hs
		1270385 HDAC2_HUMAN (1-478): 0: 666: 85.92		PWP2A_HUMAN (45-310): 1.4e-63: 230: 19.50