Protein: XRN2
5'-3' exoribonuclease 2 (EC 3.1.13.-) (Ribonucleic acid-trafficking protein 1) (p116)

Gene: XRN2, RAT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 183
UniProt ID: Q02792

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000448 - cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 - nuclear-transcribed mRNA catabolic process
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

916860

DXO
Decapping nuclease RAI1

14

4

Small-scale

0.982

High

594528

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

Small-scale

0.676

High

782177

LAS1
Protein LAS1

4

2

Small-scale

0.676

High

1031032

NOP3
Serine/arginine

4

12

Small-scale

0.676

High

804395

SSZ1
Ribosome-associated complex subunit SSZ1

3

2

High-throughput

0.650

High

1038752

RT103
Regulator of Ty1 transposition protein 103

3

1

Small-scale

0.650

High

1038738

XRN2
5'-3' exoribonuclease 2

1

4

Small-scale

0.647

High

410297

RL25
Large ribosomal subunit protein uL23

3

1

High-throughput

0.640

High

513754

RL2A
Large ribosomal subunit protein uL2A

3

2

High-throughput

0.640

High

1038761

GRC3
Polynucleotide 5'-hydroxyl-kinase GRC3

3

2

Small-scale

0.640

High

534302

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.618

High

645512

XRN1
5'-3' exoribonuclease 1

1

4

High-throughput

0.618

High

1038751

RRP5
rRNA biogenesis protein RRP5

1

3

High-throughput

0.618

High

1038772

YRA1
RNA annealing protein YRA1

2

5

High-throughput

0.601

High

403631

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

2

Small-scale

0.584

High

433807

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

435302

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.584

High

674789

RS2
Small ribosomal subunit protein uS5

2

2

High-throughput

0.584

High

689620

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.584

High

707964

TF2B
Transcription initiation factor IIB

2

1

Small-scale

0.584

High

1033519

RS15
Small ribosomal subunit protein uS19

2

1

High-throughput

0.584

High

673218

RRP7
Ribosomal RNA-processing protein 7

2

0

High-throughput

0.559

High

694625

SPT5
Transcription elongation factor SPT5

2

0

Small-scale

0.559

High

819581

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

524918

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.536

High

504379

RL31A
Large ribosomal subunit protein eL31A

2

2

High-throughput

0.533

High

512606

RS6A
Small ribosomal subunit protein eS6A

2

2

High-throughput

0.533

High

513174

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.533

High

753542

RS3A1
Small ribosomal subunit protein eS1A

2

1

High-throughput

0.533

High

874484

RS12
Small ribosomal subunit protein eS12

2

1

High-throughput

0.533

High

828505

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.515

High

1038756

YSP2
Membrane-anchored lipid-binding protein YSP2

1

0

High-throughput

0.493

High

149915

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

382295

H4
Histone H4

1

2

High-throughput

0.479

High

432679

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

435623

RS9B
Small ribosomal subunit protein uS4B

1

3

High-throughput

0.479

High

436498

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

442072

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

444605

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.479

High

455223

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

482080

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.479

High

513556

RL1A
Large ribosomal subunit protein uL1A

1

5

High-throughput

0.479

High

514182

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

514791

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

518115

SSBP1
Single-stranded nucleic acid-binding protein

1

6

High-throughput

0.479

High

531860

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

557628

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.479

High

569850

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.479

High

570121

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

579935

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

584265

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

7

High-throughput

0.479

High

632588

DBP3
ATP-dependent RNA helicase DBP3

1

3

High-throughput

0.479

High

632723

DBP4
ATP-dependent RNA helicase HCA4

1

4

High-throughput

0.479

High

633502

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.479

High

637267

PWP1
Periodic tryptophan protein 1

1

6

High-throughput

0.479

High

646510

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.479

High

666533

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

676766

GBP2
Serine/arginine

1

7

High-throughput

0.479

High

676969

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

677535

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

678732

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

4

High-throughput

0.479

High

689272

RL16B
Large ribosomal subunit protein uL13B

1

3

High-throughput

0.479

High

692611

NSR1
Nuclear localization sequence-binding protein

1

7

High-throughput

0.479

High

712654

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.479

High

735127

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

741073

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

High-throughput

0.479

High

743124

STH1
Nuclear protein STH1/NPS1

1

1

High-throughput

0.479

High

744252

ECM32
Putative ATP-dependent RNA helicase ECM32

1

6

High-throughput

0.479

High

746660

DRS1
ATP-dependent RNA helicase DRS1

1

4

High-throughput

0.479

High

747040

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

3

High-throughput

0.479

High

750133

MRT4
Ribosome assembly factor MRT4

1

1

High-throughput

0.479

High

763848

SKI2
Antiviral helicase SKI2

1

5

High-throughput

0.479

High

778496

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

781724

SA190
SIT4-associating protein SAP190

1

1

High-throughput

0.479

High

782421

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.479

High

791096

NOP4
Nucleolar protein 4

1

5

High-throughput

0.479

High

792203

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

794881

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.479

High

798292

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

802107

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

4

High-throughput

0.479

High

802341

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

803430

RL14B
Large ribosomal subunit protein eL14B

1

1

High-throughput

0.479

High

803918

CIC1
Proteasome-interacting protein CIC1

1

1

High-throughput

0.479

High

807918

BFR1
Nuclear segregation protein BFR1

1

1

High-throughput

0.479

High

809398

STM1
Suppressor protein STM1

1

1

High-throughput

0.479

High

814028

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

814372

NOC2
Nucleolar complex protein 2

1

1

High-throughput

0.479

High

815217

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

820949

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.479

High

870676

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.479

High

893149

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

4

High-throughput

0.479

High

893206

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

4

High-throughput

0.479

High

917460

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.479

High

918434

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

918806

UTP22
U3 small nucleolar RNA-associated protein 22

1

1

High-throughput

0.479

High

918962

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

919427

PBP1
PAB1-binding protein 1

1

2

High-throughput

0.479

High

922174

PAP2
Poly(A) RNA polymerase protein 2

1

2

High-throughput

0.479

High

924318

NOP13
Nucleolar protein 13

1

4

High-throughput

0.479

High

924833

NOP15
Ribosome biogenesis protein 15

1

5

High-throughput

0.479

High

963664

H3
Histone H3

1

2

High-throughput

0.479

High

1025165

SEN1
Helicase SEN1

1

7

High-throughput

0.479

High

1030558

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.479

High

1038741

HAS1
ATP-dependent RNA helicase HAS1

1

7

High-throughput

0.479

High

1038743

HMO1
High mobility group protein 1

1

3

High-throughput

0.479

High

1038745

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.479

High

1038748

PUF6
Pumilio homology domain family member 6

1

1

High-throughput

0.479

High

1038750

ERB1
Ribosome biogenesis protein ERB1

1

3

High-throughput

0.479

High

1038753

MRD1
Multiple RNA-binding domain-containing protein 1

1

5

High-throughput

0.479

High

1038755

DBP9
ATP-dependent RNA helicase DBP9

1

5

High-throughput

0.479

High

1038757

TSR1
Ribosome biogenesis protein TSR1

1

1

High-throughput

0.479

High

1038759

SUB2
ATP-dependent RNA helicase SUB2

1

3

Small-scale

0.479

High

1038760

NOP6
Nucleolar protein 6

1

1

High-throughput

0.479

High

1038762

NOC3
Nucleolar complex-associated protein 3

1

2

High-throughput

0.479

High

1038764

NOP12
Nucleolar protein 12

1

7

High-throughput

0.479

High

1038765

BRX1
Ribosome biogenesis protein BRX1

1

3

High-throughput

0.479

High

1038766

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

1038767

BMS1
Ribosome biogenesis protein BMS1

1

1

High-throughput

0.479

High

1038768

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

1038769

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

1038773

PSH1
RING finger protein PSH1

1

1

High-throughput

0.479

High

1038774

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.479

High

1038775

CLF1
Pre-mRNA-splicing factor CLF1

1

4

Small-scale

0.479

High

1038776

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.479

High

1038777

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.479

High

448999

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.458

High

454349

PHO2
Regulatory protein PHO2

1

0

High-throughput

0.458

High

512141

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

638078

ISY1
Pre-mRNA-splicing factor ISY1

1

0

Small-scale

0.458

High

663715

RL24B
Large ribosomal subunit protein eL24B

1

0

High-throughput

0.458

High

677231

SPB1
27S pre-rRNA

1

0

High-throughput

0.458

High

677958

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

702276

YJU2
Splicing factor YJU2

1

0

Small-scale

0.458

High

763613

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.458

High

783503

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

805837

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

805954

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.458

High

808296

RRP8
25S rRNA

1

0

High-throughput

0.458

High

816170

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.458

High

818266

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.458

High

830165

NOP2
25S rRNA

1

0

High-throughput

0.458

High

864948

NOP9
Nucleolar protein 9

1

0

High-throughput

0.458

High

917679

LSG1
Large subunit GTPase 1

1

0

High-throughput

0.458

High

921159

H1
Histone H1

1

0

High-throughput

0.458

High

924128

SQS1
Protein SQS1

1

0

High-throughput

0.458

High

932178

RL15B
Large ribosomal subunit protein eL15B

1

0

High-throughput

0.458

High

1036281

RL6A
Large ribosomal subunit protein eL6A

1

0

High-throughput

0.458

High

1038739

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.458

High

1038742

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.458

High

1038744

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1038746

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

1038747

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

1038754

IMB1
Importin subunit beta-1

1

0

High-throughput

0.458

High

1038763

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1038770

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1038771

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1038778

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

1038779

IGO2
mRNA stability protein IGO2

1

0

High-throughput

0.458

High

393209

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

742232

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

527492

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

545987

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

676282

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

752643

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

383856

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

436125

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

503200

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

678126

SYP1
Suppressor of yeast profilin deletion

1

1

High-throughput

0.437

High

747540

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

812593

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

843262

KRI1
Protein KRI1

1

1

High-throughput

0.437

High

924612

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.437

High

1038758

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

811145

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.407

High

757389

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

503839

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

511270

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

743716

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.249

Low

831828

RL33B
Large ribosomal subunit protein eL33B

1

0

High-throughput

0.249

Low

835872

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

1038740

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.249

Low

1038749

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025