HitPredict

Interactor 1: IRF5 (Q13568)
Interferon regulatory factor 5 (IRF-5)
Gene: IRF5

Interactor 2: CBP (Q92793)
CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
Gene: CREBBP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	20935208, 18836453
Identification Methods	affinity chromatography technology, pull down, isothermal titration calorimetry, cosedimentation in solution, molecular sieving
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Creb_binding~IRF-3
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 498 Hs			1 2442
+	Hs
		1056440 IRF3_HUMAN (14-459): 1.3e-148: 433: 30.68		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Ss
		94579 IRF3_PIG (13-459): 1.65e-147: 430: 29.80		F1RK46_PIG (1-2442): 0: 1091: 95.22
+	Hs
		971743 IRF8_HUMAN (16-454): 1.66e-141: 415: 31.25		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		998671 IRF5_HUMAN (1-498): 0: 628: 100.00		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1270761 IRF7_HUMAN (14-428): 1.73e-122: 369: 27.43		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		962717 IRF9_HUMAN (16-428): 1.26e-108: 329: 27.99		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Hs
		998733 IRF4_HUMAN (16-449): 3.8e-156: 453: 33.11		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		998708 IRF3_HUMAN (14-459): 1.3e-148: 433: 30.68		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		501074 IRF1_HUMAN (11-233): 1.28e-51: 180: 24.56		CBP_HUMAN (1-2442): 0: 1104: 100.00
+	Mm
		70908 IRF3_MOUSE (14-459): 1.65e-141: 415: 29.11		EP300_MOUSE (1-2426): 0: 867: 53.61
+	Hs
		998953 IRF7_HUMAN (14-428): 1.73e-122: 369: 27.43		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		536517 IRF2_HUMAN (11-226): 3.14e-52: 182: 26.41		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		501043 IRF1_HUMAN (11-233): 1.28e-51: 180: 24.56		EP300_HUMAN (1-2426): 0: 874: 55.06
+	Hs
		1071049 IRF4_HUMAN (16-449): 3.8e-156: 453: 33.11		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83
+	Hs
		1071078 IRF4_HUMAN (16-449): 3.8e-156: 453: 33.11		CHD7_HUMAN (70-467): 2.16e-11: 72.1: 9.68
+	Hs
		1071055 IRF4_HUMAN (16-449): 3.8e-156: 453: 33.11		KMT2C_HUMAN (1945-2437): 8.84e-10: 67.1: 13.89
+	Hs
		501062 IRF1_HUMAN (11-233): 1.28e-51: 180: 24.56		PB1_HUMAN (1040-1275): 1.29e-12: 76: 14.83