Protein: RL6B
Large ribosomal subunit protein eL6B (60S ribosomal protein L6-B) (L17) (RP18) (YL16)

Gene: RL6B, RPL6B
Organism: Saccharomyces cerevisiae S288C
Interactions: 172
UniProt ID: P05739

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

433006

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.691

High

432963

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.633

High

432430

RL7A
Large ribosomal subunit protein uL30A

1

4

High-throughput

0.618

High

432940

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.618

High

432943

RL33A
Large ribosomal subunit protein eL33A

1

2

High-throughput

0.618

High

433005

RL14A
Large ribosomal subunit protein eL14A

1

3

High-throughput

0.618

High

433065

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.618

High

432949

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

2

1

High-throughput

0.611

High

432980

SIS1
Protein SIS1

2

2

High-throughput

0.601

High

432967

CAF20
Cap-associated protein CAF20

3

1

Small-scale

0.585

High

432990

RL16A
Large ribosomal subunit protein uL13A

2

4

High-throughput

0.584

High

433000

MRT4
Ribosome assembly factor MRT4

2

4

Small-scale

0.584

High

433009

RL32
Large ribosomal subunit protein eL32

2

1

High-throughput

0.584

High

433047

DXO
Decapping nuclease RAI1

2

1

Small-scale

0.584

High

433087

TMA46
Translation machinery-associated protein 46

2

1

High-throughput

0.584

High

432974

DBP4
ATP-dependent RNA helicase HCA4

1

8

High-throughput

0.536

High

432981

RNA14
mRNA 3'-end-processing protein RNA14

1

1

High-throughput

0.536

High

433001

MPE1
Protein MPE1

1

1

High-throughput

0.536

High

433039

REF2
RNA end formation protein 2

1

1

High-throughput

0.536

High

433056

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

433064

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

433090

MAK21
Ribosome biogenesis protein MAK21

1

2

High-throughput

0.536

High

433014

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.533

High

433035

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

433042

ALB1
Ribosome biogenesis protein ALB1

2

1

High-throughput

0.533

High

433061

ORC1
Origin recognition complex subunit 1

2

2

High-throughput

0.521

High

433002

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.513

High

433083

CFT1
Protein CFT1

1

0

High-throughput

0.513

High

432985

PWP2
Periodic tryptophan protein 2

1

1

High-throughput

0.489

High

432998

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.489

High

433008

NOP4
Nucleolar protein 4

1

3

High-throughput

0.489

High

154101

RL36B
Large ribosomal subunit protein eL36B

1

2

High-throughput

0.479

High

383040

RLA4
Large ribosomal subunit protein P2B

1

3

High-throughput

0.479

High

383229

RL28
Large ribosomal subunit protein uL15

1

2

High-throughput

0.479

High

391971

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

409643

RL24A
Large ribosomal subunit protein eL24A

1

3

High-throughput

0.479

High

409820

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

427053

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.479

High

427508

RLA1
Large ribosomal subunit protein P1A

1

3

High-throughput

0.479

High

427630

RLA2
Large ribosomal subunit protein P2A

1

3

High-throughput

0.479

High

430730

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

432755

RL9A
Large ribosomal subunit protein uL6A

1

1

High-throughput

0.479

High

432941

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

432942

RL26A
Large ribosomal subunit protein uL24A

1

4

High-throughput

0.479

High

432944

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.479

High

432945

RL22A
Large ribosomal subunit protein eL22A

1

2

High-throughput

0.479

High

432946

SC160
Protein SCP160

1

5

High-throughput

0.479

High

432950

RL11A
Large ribosomal subunit protein uL5A

1

4

High-throughput

0.479

High

432951

RL27A
Large ribosomal subunit protein eL27A

1

2

High-throughput

0.479

High

432952

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

432954

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.479

High

432955

RL43B
Large ribosomal subunit protein eL43B

1

2

High-throughput

0.479

High

432956

RL44B
Large ribosomal subunit protein eL42B

1

1

High-throughput

0.479

High

432957

RL1A
Large ribosomal subunit protein uL1A

1

2

High-throughput

0.479

High

432958

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.479

High

432959

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

432960

RL12B
Large ribosomal subunit protein uL11B

1

1

High-throughput

0.479

High

432961

RL19B
Large ribosomal subunit protein eL19

1

3

High-throughput

0.479

High

432964

RLA3
Large ribosomal subunit protein P1B

1

3

High-throughput

0.479

High

432965

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.479

High

432969

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.479

High

432970

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.479

High

432972

RL8A
Large ribosomal subunit protein eL8A

1

4

High-throughput

0.479

High

432978

RL24B
Large ribosomal subunit protein eL24B

1

3

High-throughput

0.479

High

432984

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.479

High

432986

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

2

Small-scale

0.479

High

432987

CDC48
Cell division control protein 48

1

3

High-throughput

0.479

High

432988

SPB4
ATP-dependent rRNA helicase SPB4

1

6

High-throughput

0.479

High

432989

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.479

High

432991

RL16B
Large ribosomal subunit protein uL13B

1

4

High-throughput

0.479

High

432993

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.479

High

432994

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

432999

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

433011

ATG8
Autophagy-related protein 8

1

5

High-throughput

0.479

High

433012

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

High-throughput

0.479

High

433019

NMD3
60S ribosomal export protein NMD3

1

1

High-throughput

0.479

High

433021

STM1
Suppressor protein STM1

1

1

High-throughput

0.479

High

433024

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

433026

IF2P
Eukaryotic translation initiation factor 5B

1

2

High-throughput

0.479

High

433029

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.479

High

433032

RL34B
Large ribosomal subunit protein eL34B

1

3

High-throughput

0.479

High

433036

RLP7
Ribosome biogenesis protein RLP7

1

4

High-throughput

0.479

High

433037

NOP2
25S rRNA

1

1

Small-scale

0.479

High

433038

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

433041

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.479

High

433045

RL37A
Large ribosomal subunit protein eL37A

1

2

High-throughput

0.479

High

433046

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.479

High

433048

LSG1
Large subunit GTPase 1

1

2

High-throughput

0.479

High

433049

RL26B
Large ribosomal subunit protein uL24B

1

4

High-throughput

0.479

High

433052

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

433059

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

Small-scale

0.479

High

433062

RL34A
Large ribosomal subunit protein eL34A

1

3

High-throughput

0.479

High

433067

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.479

High

433070

HAS1
ATP-dependent RNA helicase HAS1

1

7

High-throughput

0.479

High

433076

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

433077

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

433080

LTN1
E3 ubiquitin-protein ligase listerin

1

2

Small-scale

0.479

High

433089

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.479

High

433092

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

433095

RL11B
Large ribosomal subunit protein uL5B

1

4

High-throughput

0.479

High

403291

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

4

Small-scale

0.445

High

432953

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

High-throughput

0.445

High

432966

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

432983

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

432996

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

433018

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

433028

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

433058

JJJ1
J protein JJJ1

1

9

High-throughput

0.445

High

433088

NOP53
Ribosome biogenesis protein NOP53

1

1

Small-scale

0.445

High

364217

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.437

High

432947

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.437

High

432968

ACOX
Acyl-coenzyme A oxidase

1

1

High-throughput

0.437

High

432975

PWP1
Periodic tryptophan protein 1

1

4

High-throughput

0.437

High

432976

KCC2
Calcium/calmodulin-dependent protein kinase II

1

2

High-throughput

0.437

High

432979

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.437

High

432992

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

432995

RPD3
Histone deacetylase RPD3

1

4

Small-scale

0.437

High

432997

CHD1
Chromo domain-containing protein 1

1

3

High-throughput

0.437

High

433004

EAP1
Protein EAP1

1

1

High-throughput

0.437

High

433007

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.437

High

433010

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

433016

YB8A
Putative uncharacterized protein YBR285W

1

1

Small-scale

0.437

High

433017

ECM29
Proteasome component ECM29

1

1

High-throughput

0.437

High

433023

DHH1
ATP-dependent RNA helicase DHH1

1

5

High-throughput

0.437

High

433025

ECM1
Shuttling pre-60S factor ECM1

1

1

High-throughput

0.437

High

433030

MLP2
Protein MLP2

1

3

High-throughput

0.437

High

433031

TM108
Protein TMA108

1

1

High-throughput

0.437

High

433040

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

433044

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

433050

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

433051

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.437

High

433054

H1
Histone H1

1

1

High-throughput

0.437

High

433055

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

Small-scale

0.437

High

433057

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.437

High

433060

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

433063

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

433066

MLP1
Protein MLP1

1

4

High-throughput

0.437

High

433069

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

433071

ARX1
Probable metalloprotease ARX1

1

3

High-throughput

0.437

High

433073

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.437

High

433074

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.437

High

433079

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

433081

RQC1
Ribosome quality control complex subunit 1

1

1

Small-scale

0.437

High

433082

RRP15
Ribosomal RNA-processing protein 15

1

1

Small-scale

0.437

High

433084

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

433085

SGO1
Shugoshin

1

1

High-throughput

0.437

High

433086

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

433093

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.437

High

433094

RQC2
Ribosome quality control complex subunit 2

1

1

High-throughput

0.437

High

433003

NDK
Nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

432982

SCJ1
DnaJ-related protein SCJ1

1

1

High-throughput

0.407

High

433034

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.407

High

433043

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.407

High

432962

MPPB
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.279

Low

433053

SDA1
Protein SDA1

1

0

High-throughput

0.279

Low

432971

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

432977

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

433013

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

433020

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

433027

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

0

High-throughput

0.249

Low

433033

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.249

Low

433068

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.249

Low

433072

FIN1
Filament protein FIN1

1

0

Small-scale

0.249

Low

433078

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.249

Low

433096

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

432948

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.232

Low

432973

SPO7
Sporulation-specific protein SPO7

1

0

High-throughput

0.232

Low

433015

RGD1
RHO GTPase-activating protein RGD1

1

0

High-throughput

0.232

Low

433022

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low

433075

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.232

Low

433091

PUS1
tRNA pseudouridine synthase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025