HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: FBX27 (Q8NI29)
F-box only protein 27 (F-box/G-domain protein 5)
Gene: FBXO27

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	18203720, 21640084
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 283
+	Hs
		1041142 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX17_HUMAN (1-283): 7.96e-129: 368: 57.34
+	Hs
		1041217 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX6_HUMAN (18-283): 1.79e-127: 365: 40.44
+	Hs
		1041202 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX44_HUMAN (25-282): 1.74e-119: 344: 38.78
+	Hs
		1041259 CUL1_HUMAN (1-776): 0: 911: 100.00		FBX2_HUMAN (37-280): 1.79e-102: 302: 40.00
+	Mm
		1193600 CUL1_MOUSE (1-776): 0: 912: 99.87		FBX2_MOUSE (37-280): 3.59e-100: 296: 39.76
+	Hs
		1043220 CUL4A_HUMAN (7-776): 0: 781: 30.41		FBX44_HUMAN (25-282): 1.74e-119: 344: 38.78
+	Hs
		1043585 CUL4B_HUMAN (7-776): 0: 773: 29.90		FBX44_HUMAN (25-282): 1.74e-119: 344: 38.78
+	Hs
		1274013 CUL5_HUMAN (2-776): 0: 622: 28.85		FBX17_HUMAN (1-283): 7.96e-129: 368: 57.34