HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: SF3B3 (Q15393)
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
Gene: SF3B3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	21145461, 23951410
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~Cullin, Cullin~MMS1_N
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0044877 - protein-containing complex binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 1217
+	Hs
		1040995 CUL1_HUMAN (6-745): 0: 775: 36.24		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1043002 CUL4A_HUMAN (4-745): 0: 773: 26.86		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1041634 CUL3_HUMAN (1-745): 0: 768: 26.38		SF3B3_HUMAN (1-1217): 0: 1474: 100.00
+	Hs
		1041008 CUL1_HUMAN (6-745): 0: 775: 36.24		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Mm
		1111812 CUL4A_MOUSE (4-745): 0: 774: 26.73		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	Hs
		1043013 CUL4A_HUMAN (4-745): 0: 773: 26.86		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Hs
		1043374 CUL4B_HUMAN (4-745): 0: 771: 27.79		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Mm
		56795 CUL4B_MOUSE (4-745): 0: 771: 27.79		DDB1_MOUSE (2-1211): 0: 1062: 21.02
+	Hs
		1041668 CUL3_HUMAN (1-745): 0: 768: 26.38		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	At
		1228145 CUL4_ARATH (4-745): 0: 720: 26.60		DDB1A_ARATH (2-1211): 0: 1039: 20.03
+	At
		221829 CUL4_ARATH (4-745): 0: 720: 26.60		DDB1B_ARATH (1-1211): 0: 1032: 20.10
+	Dm
		1124382 Q5BI50_DROME (4-745): 0: 742: 27.06		DDB1_DROME (2-1211): 0: 948: 19.94
+	Hs
		1082313 CUL5_HUMAN (7-745): 0: 627: 26.69		DDB1_HUMAN (2-1211): 0: 1062: 21.10
+	Ce
		1088892 CUL4_CAEEL (14-745): 0: 575: 22.09		DDB1_CAEEL (3-1211): 0: 832: 18.50
+	Hs
		1014118 CUL4A_HUMAN (4-745): 0: 773: 26.86		CPSF1_HUMAN (701-1216): 4.42e-121: 410: 15.99
+	Hs
		1014117 CUL3_HUMAN (1-745): 0: 768: 26.38		CPSF1_HUMAN (701-1216): 4.42e-121: 410: 15.99