Protein: DIAP3
Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (MDia2)

Gene: DIAP3, DIAPH3
Organism: Homo sapiens
Interactions: 110
UniProt ID: Q9NSV4

Gene Ontology (top 5):
GO:0000813 - ESCRT I complex
GO:0000922 - spindle pole
GO:0001701 - in utero embryonic development
GO:0003779 - actin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

955654

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.768

High

962540

RHOA
Transforming protein RhoA

2

20

Small-scale

0.768

High

988751

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

Small-scale

0.768

High

978340

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

262319

SCN2B
Sodium channel regulatory subunit beta-2

3

4

High-throughput

0.667

High

1251116

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

3

2

High-throughput

0.667

High

1273284

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

4

0

High-throughput

0.661

High

1232138

VASN
Vasorin

2

1

High-throughput

0.628

High

126824

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

374963

RASH
GTPase HRas

1

12

High-throughput

0.618

High

375996

RASK
GTPase KRas

1

19

High-throughput

0.618

High

466485

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581318

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601464

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

631506

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.618

High

953134

ACTB
Actin, cytoplasmic 1

1

16

High-throughput

0.618

High

953699

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

976594

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

1015833

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1145128

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

1433530

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1438179

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1213044

CC183
Coiled-coil domain-containing protein 183

3

5

High-throughput

0.609

High

640303

EPHA1
Ephrin type-A receptor 1

3

5

High-throughput

0.604

High

686870

S10A4
Protein S100-A4

2

3

High-throughput

0.601

High

1326233

PNKD
Probable thioesterase PNKD

2

0

High-throughput

0.585

High

1108194

SQSTM
Sequestosome-1

2

2

High-throughput

0.584

High

441452

CHLE
Cholinesterase

2

1

High-throughput

0.574

High

1227538

A16L1
Autophagy-related protein 16-1

2

4

High-throughput

0.571

High

1143555

PCM1
Pericentriolar material 1 protein

2

0

High-throughput

0.559

High

1449461

SPN90
NCK-interacting protein with SH3 domain

1

0

Small-scale

0.549

High

606041

CAN2
Calpain-2 catalytic subunit

1

4

High-throughput

0.536

High

1111299

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

388309

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

1323273

SIX5
Homeobox protein SIX5

1

0

High-throughput

0.513

High

1445995

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.513

High

276532

PDCD6
Programmed cell death protein 6

1

6

Small-scale

0.501

High

130260

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.493

High

1388750

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.493

High

1249857

BTNL9
Butyrophilin-like protein 9

1

2

High-throughput

0.489

High

1403445

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

181948

SMAD9
Mothers against decapentaplegic homolog 9

1

0

High-throughput

0.486

High

124974

GTPB1
GTP-binding protein 1

1

3

High-throughput

0.479

High

164108

NDC80
Kinetochore protein NDC80 homolog

1

8

High-throughput

0.479

High

173432

XPO1
Exportin-1

1

5

High-throughput

0.479

High

226222

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

247443

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

294396

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

323581

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.479

High

373262

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

459769

PROF1
Profilin-1

1

11

High-throughput

0.479

High

556368

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

582983

EZRI
Ezrin

1

5

High-throughput

0.479

High

696626

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

883707

CENPA
Histone H3-like centromeric protein A

1

4

Small-scale

0.479

High

935181

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

1041319

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1095816

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

10

High-throughput

0.479

High

1110121

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

1123838

DCTN1
Dynactin subunit 1

1

6

High-throughput

0.479

High

1138679

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1140922

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

1152262

MARE1
Microtubule-associated protein RP/EB family member 1

1

5

High-throughput

0.479

High

1233518

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1255729

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1276846

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1326359

NIN
Ninein

1

8

High-throughput

0.479

High

1363864

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

1368962

GOGA1
Golgin subfamily A member 1

1

4

High-throughput

0.479

High

1403801

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

1428383

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.479

High

1428986

WWTR1
WW domain-containing transcription regulator protein 1

1

6

High-throughput

0.479

High

1434004

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1449460

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1449462

HDAC6
Protein deacetylase HDAC6

1

8

Small-scale

0.479

High

1449463

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

1449465

MARE3
Microtubule-associated protein RP/EB family member 3

1

5

High-throughput

0.479

High

1449466

NINL
Ninein-like protein

1

6

High-throughput

0.479

High

1449467

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

246983

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

290171

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

346387

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

437367

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

605824

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.458

High

961859

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

1110739

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1214581

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1322456

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.458

High

1365373

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1429859

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1435344

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1315539

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

4

High-throughput

0.445

High

1415932

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

5

High-throughput

0.445

High

769294

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1241970

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1384456

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

344334

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

532178

CD28
T-cell-specific surface glycoprotein CD28

1

0

High-throughput

0.426

High

1290434

LRRT3
Leucine-rich repeat transmembrane neuronal protein 3

1

1

High-throughput

0.407

High

1248843

ENPP6
Glycerophosphocholine cholinephosphodiesterase ENPP6

3

0

High-throughput

0.347

High

1291693

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

71253

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

1178896

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1429434

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

1449464

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

140004

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

643092

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

1418465

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

683347

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

1279090

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025