HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.742

Property	Details
Experiments	27320910, 34655362, 17439941, 17132228, 19940151, 23401859, 18323857
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 826
+	Rn
		88863 D4A0H4_RAT (1-745): 0: 813: 94.90		HIF1A_RAT (1-826): 0: 714: 89.40
+	Hs
		1041447 CUL2_HUMAN (1-745): 0: 840: 100.00		EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24
+	Hs
		649102 CUL2_HUMAN (1-745): 0: 840: 100.00		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		728914 CUL4B_HUMAN (4-745): 0: 771: 27.79		AHR_HUMAN (7-745): 4.08e-113: 366: 15.97
+	Hs
		126128 CUL1_HUMAN (6-745): 0: 775: 36.24		BMAL1_HUMAN (7-505): 9.03e-114: 361: 20.88
+	Hs
		728913 CUL3_HUMAN (1-745): 0: 768: 26.38		AHR_HUMAN (7-745): 4.08e-113: 366: 15.97
+	Hs
		649103 CUL4A_HUMAN (4-745): 0: 773: 26.86		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		1042962 CUL3_HUMAN (1-745): 0: 768: 26.38		NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31