HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: CASP8 (Q14790)
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Gene: CASP8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.687

Property	Details
Experiments	25551360, 19427028, 28574503, 23142077
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 479
+	Hs
		788253 CUL3_HUMAN (1-768): 0: 951: 100.00		CASP2_HUMAN (212-478): 3.31e-94: 294: 27.60
+	Hs
		667463 CUL3_HUMAN (1-768): 0: 951: 100.00		CASP1_HUMAN (192-478): 1.67e-85: 270: 22.33
+	Hs
		181614 CUL1_HUMAN (18-768): 0: 707: 30.57		CFLAR_HUMAN (5-476): 9.95e-137: 404: 25.30
+	Hs
		683077 CUL4A_HUMAN (10-768): 0: 791: 38.32		CASPE_HUMAN (258-476): 3.03e-64: 209: 29.46
+	Hs
		683076 CUL2_HUMAN (30-768): 0: 672: 26.17		CASPE_HUMAN (258-476): 3.03e-64: 209: 29.46