HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: NR1D2 (Q14995)
Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
Gene: NR1D2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 579
+	Mm
		846444 CUL3_MOUSE (1-768): 0: 949: 99.48		RORG_MOUSE (91-579): 4.67e-104: 325: 30.72
+	Hs
		823983 CUL4A_HUMAN (10-768): 0: 791: 38.32		NR2C2_HUMAN (30-574): 1e-117: 363: 18.85
+	Hs
		823984 CUL4B_HUMAN (5-768): 0: 779: 36.77		NR2C2_HUMAN (30-574): 1e-117: 363: 18.85
+	Hs
		369559 CUL3_HUMAN (1-768): 0: 951: 100.00		ESR1_HUMAN (204-576): 1.49e-45: 171: 13.15
+	Hs
		622792 CUL3_HUMAN (1-768): 0: 951: 100.00		COT2_HUMAN (36-287): 1.47e-44: 165: 26.09
+	Hs
		659714 CUL3_HUMAN (1-768): 0: 951: 100.00		RXRB_HUMAN (46-199): 6.14e-43: 163: 29.87
+	Hs
		874380 CUL3_HUMAN (1-768): 0: 951: 100.00		NR1H2_HUMAN (12-187): 8.69e-42: 158: 29.35
+	Hs
		846411 CUL4B_HUMAN (5-768): 0: 779: 36.77		RORG_HUMAN (83-579): 2.12e-104: 326: 30.12
+	Hs
		1030586 CUL4B_HUMAN (5-768): 0: 779: 36.77		STF1_HUMAN (96-577): 2.6e-83: 269: 19.35
+	Hs
		369560 CUL4B_HUMAN (5-768): 0: 779: 36.77		ESR1_HUMAN (204-576): 1.49e-45: 171: 13.15
+	Hs
		818874 CUL1_HUMAN (18-768): 0: 707: 30.57		RXRG_HUMAN (6-338): 9.84e-53: 188: 19.22
+	Hs
		369558 CUL1_HUMAN (18-768): 0: 707: 30.57		ESR1_HUMAN (204-576): 1.49e-45: 171: 13.15