Protein: NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)

Gene: NUCKS, NUCKS1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q9H1E3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0001678 - intracellular glucose homeostasis
GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

855515

ATRX
Transcriptional regulator ATRX

2

4

Small-scale

0.639

High

355597

NSD2
Histone-lysine N-methyltransferase NSD2

2

2

Small-scale

0.611

High

596348

H12
Histone H1.2

2

1

High-throughput

0.611

High

625617

CSK22
Casein kinase II subunit alpha'

2

2

High-throughput

0.611

High

998014

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.611

High

1258938

H32
Histone H3.2

2

2

High-throughput

0.611

High

905128

MECP2
Methyl-CpG-binding protein 2

2

0

High-throughput

0.585

High

1028389

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.569

High

180922

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

243732

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

High-throughput

0.536

High

277814

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.536

High

283143

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.536

High

285470

EED
Polycomb protein EED

1

1

High-throughput

0.536

High

316985

MTA2
Metastasis-associated protein MTA2

1

2

High-throughput

0.536

High

320357

PHF14
PHD finger protein 14

1

1

High-throughput

0.536

High

332044

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.536

High

487742

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

502122

H2AZ
Histone H2A.Z

1

3

High-throughput

0.536

High

542648

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

595866

H13
Histone H1.3

1

1

High-throughput

0.536

High

703377

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

2

High-throughput

0.536

High

718624

CDC27
Cell division cycle protein 27 homolog

1

1

High-throughput

0.536

High

755789

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.536

High

756344

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.536

High

770053

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.536

High

853404

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

903478

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

2

High-throughput

0.536

High

936676

BRPF1
Peregrin

1

4

High-throughput

0.536

High

1014198

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

1039567

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1041596

KMT2A
Histone-lysine N-methyltransferase 2A

1

2

High-throughput

0.536

High

1066488

RBBP4
Histone-binding protein RBBP4

1

2

High-throughput

0.536

High

1097552

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.536

High

1102649

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.536

High

1115051

CUL4A
Cullin-4A

1

1

High-throughput

0.536

High

1115418

CUL4B
Cullin-4B

1

1

High-throughput

0.536

High

1123603

ZMYM3
Zinc finger MYM-type protein 3

1

1

High-throughput

0.536

High

1128285

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.536

High

1129740

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.536

High

1145524

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.536

High

1155753

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.536

High

1159000

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.536

High

1163200

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1217195

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.536

High

1232728

H2A2A
Histone H2A type 2-A

1

2

High-throughput

0.536

High

1253871

SRCAP
Helicase SRCAP

1

3

High-throughput

0.536

High

1273159

KDM3B
Lysine-specific demethylase 3B

1

1

High-throughput

0.536

High

1277233

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.536

High

1278973

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.536

High

1279171

RAI1
Retinoic acid-induced protein 1

1

3

High-throughput

0.536

High

1287984

PB1
Protein polybromo-1

1

2

High-throughput

0.536

High

1307320

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

1336372

Z280C
Zinc finger protein 280C

1

1

High-throughput

0.536

High

1359699

PHIP
PH-interacting protein

1

2

High-throughput

0.536

High

1361578

ING5
Inhibitor of growth protein 5

1

1

High-throughput

0.536

High

1368614

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.536

High

1372246

H2A1C
Histone H2A type 1-C

1

2

High-throughput

0.536

High

1380007

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

High-throughput

0.536

High

1395203

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.536

High

1403258

RSF1
Remodeling and spacing factor 1

1

3

High-throughput

0.536

High

1403653

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

2

High-throughput

0.536

High

1416766

CECR2
Chromatin remodeling regulator CECR2

1

6

High-throughput

0.536

High

1431059

HM20A
High mobility group protein 20A

1

1

High-throughput

0.536

High

1431060

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.536

High

1431064

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

6

High-throughput

0.536

High

1431067

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

1431068

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.536

High

1431071

TCF20
Transcription factor 20

1

2

High-throughput

0.536

High

1431073

BAZ1B
Tyrosine-protein kinase BAZ1B

1

7

High-throughput

0.536

High

1431074

APC7
Anaphase-promoting complex subunit 7

1

1

High-throughput

0.536

High

1431075

RCOR1
REST corepressor 1

1

2

High-throughput

0.536

High

1431079

MTF2
Metal-response element-binding transcription factor 2

1

1

High-throughput

0.536

High

1431080

KAD5
Adenylate kinase isoenzyme 5

1

0

High-throughput

0.518

High

285721

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

331313

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.513

High

446544

DPOLB
DNA polymerase beta

1

0

High-throughput

0.513

High

455868

H10
Histone H1.0

1

0

High-throughput

0.513

High

470340

NEP
Neprilysin

1

0

Small-scale

0.513

High

507363

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

559493

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

600202

ZNF22
Zinc finger protein 22

1

0

High-throughput

0.513

High

650578

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

0

High-throughput

0.513

High

658399

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.513

High

671856

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

681023

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.513

High

770290

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

829147

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.513

High

892619

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

892940

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.513

High

965235

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.513

High

980308

H4
Histone H4

1

0

High-throughput

0.513

High

985554

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

1008345

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.513

High

1086694

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

1134717

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

1137519

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.513

High

1157923

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

1200145

BOREA
Borealin

1

0

High-throughput

0.513

High

1210530

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1228912

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.513

High

1229202

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

1335889

RN169
E3 ubiquitin-protein ligase RNF169

1

0

High-throughput

0.513

High

1340914

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.513

High

1346785

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.513

High

1363624

H1X
Histone H1.10

1

0

High-throughput

0.513

High

1370704

SMRC1
SWI/SNF complex subunit SMARCC1

1

0

High-throughput

0.513

High

1395288

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1398070

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1431062

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.513

High

1431063

CHRC1
Chromatin accessibility complex protein 1

1

0

High-throughput

0.513

High

1431065

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.513

High

1431070

KDM5B
Lysine-specific demethylase 5B

1

0

High-throughput

0.513

High

1431078

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

1219750

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

1383910

R51A1
RAD51-associated protein 1

1

0

Small-scale

0.480

High

260441

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

302637

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.479

High

636147

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

981085

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

998794

H31
Histone H3.1

1

2

High-throughput

0.479

High

1017201

H33
Histone H3.3

1

2

High-throughput

0.479

High

1067706

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

1337836

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1364246

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1431077

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.479

High

247425

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

254427

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

363839

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

375932

RASK
GTPase KRas

1

0

High-throughput

0.458

High

426574

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

537888

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

589655

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

615589

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

696471

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769142

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

772204

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

833478

WNT5A
Protein Wnt-5a

1

0

High-throughput

0.458

High

930051

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

971065

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

986712

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

995813

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1033221

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1045757

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1107198

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1138044

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1252046

EMAL6
Echinoderm microtubule-associated protein-like 6

1

0

High-throughput

0.458

High

1255487

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1271087

ERIP6
Glutamate-rich protein 6

1

0

High-throughput

0.458

High

1289617

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1334902

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1339706

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1364587

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1413309

DIDO1
Death-inducer obliterator 1

1

0

High-throughput

0.458

High

1431057

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

1431066

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1431069

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1431072

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

530364

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

944070

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1154926

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.445

High

1431058

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

404909

PRIO
Major prion protein

1

0

High-throughput

0.426

High

442805

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

887212

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

846097

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.288

High

1419477

DOCK9
Dedicator of cytokinesis protein 9

1

0

High-throughput

0.282

High

1385511

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.279

Low

65211

OR6C6
Olfactory receptor 6C6

1

0

High-throughput

0.249

Low

106633

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

322785

SO2B1
Solute carrier organic anion transporter family member 2B1

1

0

High-throughput

0.249

Low

590942

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

1178686

RHG31
Rho GTPase-activating protein 31

1

0

High-throughput

0.249

Low

1385861

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1431061

CK016
Uncharacterized protein C11orf16

1

0

High-throughput

0.249

Low

1431076

COHA1
Collagen alpha-1(XVII) chain

1

0

High-throughput

0.249

Low

1257229

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025