HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLH17 (Q6TDP4)
Kelch-like protein 17 (Actinfilin)
Gene: KLHL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0016567 - protein ubiquitination GO:0031208 - POZ domain binding GO:0098978 - glutamatergic synapse GO:0140252 - regulation protein catabolic process at postsynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 642
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (1-642): 0: 543: 97.04
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (72-625): 1.67e-169: 497: 40.40
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (65-622): 5.89e-165: 485: 42.93
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (65-624): 1.04e-156: 466: 36.83
+	Hs
		1042727 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH13_HUMAN (55-641): 4.61e-155: 463: 28.36
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (61-622): 5.42e-156: 462: 40.98
+	Hs
		1042026 CUL3_HUMAN (1-768): 0: 951: 100.00		Q8N4I8_HUMAN (74-335): 2.15e-95: 297: 53.23
+	Hs
		1042324 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL5_HUMAN (417-641): 1.26e-64: 228: 41.33
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (417-641): 2.18e-63: 224: 37.78
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (417-641): 1.52e-62: 222: 38.22
+	Hs
		1042768 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL3_HUMAN (438-640): 1.32e-55: 200: 40.00
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (438-641): 6.78e-55: 199: 32.68
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (417-640): 7.4e-53: 193: 36.73
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (438-640): 1.02e-48: 181: 26.67
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (470-641): 1.48e-35: 144: 31.25
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (447-642): 9.5e-33: 135: 24.62
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (484-633): 3.8e-31: 130: 27.22
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (487-641): 4.76e-25: 112: 21.08
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH25_HUMAN (529-636): 2.54e-13: 75.1: 19.27
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (446-623): 1.15e-11: 69.7: 26.34