HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KCD17 (Q8N5Z5)
BTB/POZ domain-containing protein KCTD17
Gene: KCTD17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	25270598, 33961781, 34342229, 26334369, 28963344, 33130828, 34878901, 35563538, 21145461
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0030030 - cell projection organization GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 314
+	Hs
		1041584 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD2_HUMAN (17-212): 5.93e-73: 227: 68.18
+	Hs
		1042675 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD5_HUMAN (13-212): 7.69e-64: 203: 73.13
+	Hs
		1042523 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD3_HUMAN (3-203): 5.32e-48: 164: 27.23
+	Hs
		1041533 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD2_HUMAN (5-203): 2.51e-46: 160: 26.00
+	Hs
		1042165 CUL3_HUMAN (1-768): 0: 951: 100.00		BACD1_HUMAN (4-178): 1.04e-45: 159: 28.98
+	Hs
		1041705 CUL3_HUMAN (1-768): 0: 951: 100.00		KCD21_HUMAN (23-123): 3.68e-43: 150: 38.24
+	Hs
		1042096 CUL3_HUMAN (1-768): 0: 951: 100.00		SHKB1_HUMAN (14-122): 3.69e-38: 145: 44.95
+	Hs
		1041881 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD1_HUMAN (2-132): 1.06e-40: 144: 25.76
+	Hs
		1041891 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD9_HUMAN (4-174): 1.13e-39: 144: 30.11
+	Hs
		1042934 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD3_HUMAN (13-131): 1.21e-36: 140: 46.22
+	Hs
		1042309 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD7_HUMAN (24-131): 3.35e-34: 128: 36.11
+	Hs
		1042063 CUL3_HUMAN (1-768): 0: 951: 100.00		KCTD6_HUMAN (23-119): 4.33e-31: 118: 41.84
+	Dm
		1213854 Q8IP45_DROME (17-768): 0: 868: 69.08		Q9W579_DROME (12-212): 3.77e-62: 197: 54.46
+	Ce
		1088878 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18776_CAEEL (9-209): 8.85e-63: 201: 50.25
+	Ce
		954547 CUL3_CAEEL (4-768): 0: 792: 48.08		P91563_CAEEL (23-216): 3.48e-49: 165: 25.76
+	Ce
		1088887 CUL3_CAEEL (4-768): 0: 792: 48.08		Q965M5_CAEEL (21-216): 5.7e-45: 153: 21.83
+	Ce
		109385 CUL3_CAEEL (4-768): 0: 792: 48.08		H2KY83_CAEEL (22-178): 8.97e-40: 139: 27.04
+	Ce
		184054 CUL3_CAEEL (4-768): 0: 792: 48.08		O16612_CAEEL (22-170): 1.64e-38: 137: 22.73
+	Ce
		1088879 CUL3_CAEEL (4-768): 0: 792: 48.08		Q18986_CAEEL (22-124): 3.67e-37: 134: 35.58
+	Hs
		1041480 CUL2_HUMAN (30-768): 0: 672: 26.17		KCTD5_HUMAN (13-212): 7.69e-64: 203: 73.13