Protein: K2C5
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)

Gene: K2C5, KRT5
Organism: Homo sapiens
Interactions: 201
UniProt ID: P13647

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

566330

K1C15
Keratin, type I cytoskeletal 15

4

20

High-throughput

0.903

High

300722

KRT38
Keratin, type I cuticular Ha8

3

20

High-throughput

0.871

High

566387

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.871

High

566401

K1C40
Keratin, type I cytoskeletal 40

3

20

High-throughput

0.871

High

385047

K1C14
Keratin, type I cytoskeletal 14

2

20

Small-scale

0.846

High

475510

K1C19
Keratin, type I cytoskeletal 19

3

20

High-throughput

0.843

High

476261

K1C16
Keratin, type I cytoskeletal 16

3

20

High-throughput

0.843

High

436782

K1C18
Keratin, type I cytoskeletal 18

3

20

Small-scale

0.821

High

566390

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

566411

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

566412

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

566413

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

566429

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

566362

K1C17
Keratin, type I cytoskeletal 17

2

20

High-throughput

0.754

High

566442

KIFC3
Kinesin-like protein KIFC3

3

9

High-throughput

0.675

High

300293

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.621

High

300548

KRT36
Keratin, type I cuticular Ha6

1

20

High-throughput

0.621

High

300624

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.621

High

566235

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.621

High

566378

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.621

High

566379

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

341733

K2C75
Keratin, type II cytoskeletal 75

1

20

High-throughput

0.618

High

385231

K2C6A
Keratin, type II cytoskeletal 6A

1

20

High-throughput

0.618

High

407247

K2C6B
Keratin, type II cytoskeletal 6B

1

20

High-throughput

0.618

High

407377

K2C1
Keratin, type II cytoskeletal 1

1

20

High-throughput

0.618

High

437077

K2C8
Keratin, type II cytoskeletal 8

1

19

High-throughput

0.618

High

474440

VIME
Vimentin

1

20

High-throughput

0.618

High

475739

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.618

High

551532

K2C3
Keratin, type II cytoskeletal 3

1

19

High-throughput

0.618

High

566093

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.618

High

566328

DESM
Desmin

1

20

High-throughput

0.618

High

566336

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.618

High

566337

K22E
Keratin, type II cytoskeletal 2 epidermal

1

18

High-throughput

0.618

High

566339

PERI
Peripherin

1

20

High-throughput

0.618

High

566343

K2C6C
Keratin, type II cytoskeletal 6C

1

19

High-throughput

0.618

High

566360

K22O
Keratin, type II cytoskeletal 2 oral

1

20

High-throughput

0.618

High

566382

K2C72
Keratin, type II cytoskeletal 72

1

20

High-throughput

0.618

High

566391

K2C71
Keratin, type II cytoskeletal 71

1

20

High-throughput

0.618

High

566399

K2C79
Keratin, type II cytoskeletal 79

1

19

High-throughput

0.618

High

566410

K2C74
Keratin, type II cytoskeletal 74

1

20

High-throughput

0.618

High

566414

K2C1B
Keratin, type II cytoskeletal 1b

1

20

High-throughput

0.618

High

566418

K2C73
Keratin, type II cytoskeletal 73

1

20

High-throughput

0.618

High

566438

K1C12
Keratin, type I cytoskeletal 12

1

20

High-throughput

0.618

High

566460

KRT84
Keratin, type II cuticular Hb4

1

20

High-throughput

0.618

High

566368

MTM1
Myotubularin

2

1

High-throughput

0.611

High

566366

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

271864

OBSL1
Obscurin-like protein 1

2

8

High-throughput

0.584

High

413104

P53
Cellular tumor antigen p53

2

7

Small-scale

0.584

High

566392

LARP7
La-related protein 7

2

10

High-throughput

0.584

High

362682

EGFR
Epidermal growth factor receptor

2

6

Small-scale

0.571

High

566440

PKP2
Plakophilin-2

1

6

Small-scale

0.561

High

566329

LOX12
Polyunsaturated fatty acid lipoxygenase ALOX12

1

0

Small-scale

0.549

High

566334

APC
Adenomatous polyposis coli protein

1

5

High-throughput

0.541

High

340287

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.536

High

388977

FINC
Fibronectin

1

6

High-throughput

0.536

High

389949

ALBU
Albumin

1

2

High-throughput

0.536

High

566364

BTK
Tyrosine-protein kinase BTK

1

2

Small-scale

0.536

High

566369

CUL1
Cullin-1

1

20

High-throughput

0.536

High

566370

CUL2
Cullin-2

1

20

High-throughput

0.536

High

566371

CUL3
Cullin-3

1

20

High-throughput

0.536

High

566372

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

566384

FL2D
Pre-mRNA-splicing regulator WTAP

1

5

High-throughput

0.536

High

566388

NEDD8
Ubiquitin-like protein NEDD8

1

3

High-throughput

0.536

High

566409

CSN6
COP9 signalosome complex subunit 6

1

9

High-throughput

0.536

High

566415

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

12

High-throughput

0.536

High

566416

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.536

High

566417

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

566425

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.536

High

566431

CSN5
COP9 signalosome complex subunit 5

1

14

High-throughput

0.536

High

566432

CUL5
Cullin-5

1

20

High-throughput

0.536

High

566437

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

566454

P63
Tumor protein 63

1

7

Small-scale

0.536

High

566457

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

12

High-throughput

0.536

High

566441

TCHP
Trichoplein keratin filament-binding protein

1

10

Small-scale

0.527

High

566363

UBE3A
Ubiquitin-protein ligase E3A

1

3

Small-scale

0.501

High

566359

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.484

High

136279

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

141307

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

Small-scale

0.479

High

187277

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

High-throughput

0.479

High

209462

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

227345

SPOP
Speckle-type POZ protein

1

8

High-throughput

0.479

High

240626

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

277266

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.479

High

293138

CD123
Translation initiation factor eIF2 assembly protein

1

8

High-throughput

0.479

High

302356

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

High-throughput

0.479

High

323144

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

324482

HEXI1
Protein HEXIM1

1

17

High-throughput

0.479

High

348956

LATS1
Serine/threonine-protein kinase LATS1

1

6

High-throughput

0.479

High

371052

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

405744

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

442989

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

2

Small-scale

0.479

High

458262

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

482295

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

484886

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

521182

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.479

High

563098

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.479

High

566326

DESP
Desmoplakin

1

20

Small-scale

0.479

High

566331

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

566333

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.479

High

566335

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

566338

IF4A3
Eukaryotic initiation factor 4A-III

1

9

High-throughput

0.479

High

566340

EPS15
Epidermal growth factor receptor substrate 15

1

11

High-throughput

0.479

High

566341

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

566342

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

566344

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

566345

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

566346

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

566349

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

566350

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

7

High-throughput

0.479

High

566352

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

566353

RND3
Rho-related GTP-binding protein RhoE

1

1

High-throughput

0.479

High

566354

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.479

High

566355

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

566356

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

566357

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.479

High

566358

H33
Histone H3.3

1

1

High-throughput

0.479

High

566367

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.479

High

566373

PKP1
Plakophilin-1

1

4

Small-scale

0.479

High

566374

DX39B
Spliceosome RNA helicase DDX39B

1

18

High-throughput

0.479

High

566377

DCTN1
Dynactin subunit 1

1

15

High-throughput

0.479

High

566380

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

High-throughput

0.479

High

566381

CUL7
Cullin-7

1

5

High-throughput

0.479

High

566385

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

566386

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

13

High-throughput

0.479

High

566389

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

566393

MIDN
Midnolin

1

1

High-throughput

0.479

High

566394

DCAF6
DDB1- and CUL4-associated factor 6

1

6

High-throughput

0.479

High

566397

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

1

High-throughput

0.479

High

566398

OTU1
Ubiquitin thioesterase OTU1

1

6

High-throughput

0.479

High

566400

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

566402

PRP8
Pre-mRNA-processing-splicing factor 8

1

7

High-throughput

0.479

High

566404

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.479

High

566406

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

566407

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

566408

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.479

High

566419

RBM45
RNA-binding protein 45

1

1

High-throughput

0.479

High

566421

RHG24
Rho GTPase-activating protein 24

1

4

High-throughput

0.479

High

566423

TNIP2
TNFAIP3-interacting protein 2

1

3

High-throughput

0.479

High

566424

TRI58
E3 ubiquitin-protein ligase TRIM58

1

5

Small-scale

0.479

High

566426

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

566427

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

566428

RND1
Rho-related GTP-binding protein Rho6

1

1

High-throughput

0.479

High

566430

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.479

High

566433

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

6

Small-scale

0.479

High

566434

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

566435

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

566436

RNF31
E3 ubiquitin-protein ligase RNF31

1

13

High-throughput

0.479

High

566439

NECD
Necdin

1

3

High-throughput

0.479

High

566445

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

566446

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

7

High-throughput

0.479

High

566447

TRI31
E3 ubiquitin-protein ligase TRIM31

1

16

High-throughput

0.479

High

566449

DDX24
ATP-dependent RNA helicase DDX24

1

17

High-throughput

0.479

High

566451

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

566452

RN208
RING finger protein 208

1

19

Small-scale

0.479

High

566453

ATG5
Autophagy protein 5

1

2

High-throughput

0.479

High

566456

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

566458

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

9

High-throughput

0.479

High

566459

ANLN
Anillin

1

10

High-throughput

0.479

High

566461

RNF12
E3 ubiquitin-protein ligase RLIM

1

13

High-throughput

0.479

High

566462

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

566463

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

Small-scale

0.479

High

566466

HDAC6
Protein deacetylase HDAC6

1

11

High-throughput

0.479

High

566467

KS6B2
Ribosomal protein S6 kinase beta-2

1

4

High-throughput

0.479

High

566468

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

566469

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

566471

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

566473

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

566361

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

566464

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

566465

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

566444

RNF26
E3 ubiquitin-protein ligase RNF26

1

2

Small-scale

0.457

High

327774

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

379206

IGHG1
Immunoglobulin heavy constant gamma 1

1

5

High-throughput

0.445

High

528977

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

566325

TCTP
Translationally-controlled tumor protein

1

2

Small-scale

0.445

High

566351

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

566365

LG3BP
Galectin-3-binding protein

1

7

High-throughput

0.445

High

566375

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

5

High-throughput

0.445

High

566395

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

566448

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

566450

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

566455

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

105234

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

192439

INSI1
Insulin-induced gene 1 protein

1

6

High-throughput

0.437

High

377940

TNFA
Tumor necrosis factor

1

4

High-throughput

0.437

High

566327

TIMP2
Metalloproteinase inhibitor 2

1

5

High-throughput

0.437

High

566332

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

566347

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

566348

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

566376

TRI29
Tripartite motif-containing protein 29

1

10

Small-scale

0.437

High

566383

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.437

High

566396

RC3H1
Roquin-1

1

5

High-throughput

0.437

High

566405

LRC31
Leucine-rich repeat-containing protein 31

1

7

High-throughput

0.437

High

566422

NIN
Ninein

1

15

High-throughput

0.437

High

566443

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

566470

PHTF1
Protein PHTF1

1

9

High-throughput

0.437

High

566472

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

566474

INSI2
Insulin-induced gene 2 protein

1

6

High-throughput

0.437

High

911

SIM26
Small integral membrane protein 26

1

5

High-throughput

0.407

High

566420

SULF2
Extracellular sulfatase Sulf-2

1

8

High-throughput

0.407

High

566403

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025