HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: DCNL1 (Q96GG9)
DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
Gene: DCUN1D1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.985

Property	Details
Experiments	28514442, 33961781, 35563538, 21145461, 19617556, 25349211, 23201271, 26906416, 30587576, 18826954, 24192928
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~Cullin_binding
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 259
+	Hs
		1041837 CUL3_HUMAN (1-768): 0: 951: 100.00		DCNL2_HUMAN (1-257): 3.46e-130: 370: 78.21
+	Hs
		1042176 CUL3_HUMAN (1-768): 0: 951: 100.00		DCNL4_HUMAN (42-250): 9.75e-90: 269: 31.10
+	Hs
		1041979 CUL3_HUMAN (1-768): 0: 951: 100.00		DCNL3_HUMAN (54-250): 7.87e-85: 257: 41.58
+	Hs
		1042423 CUL3_HUMAN (1-768): 0: 951: 100.00		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Hs
		1043159 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCNL1_HUMAN (1-259): 3.35e-134: 380: 100.00
+	Hs
		1043062 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCNL2_HUMAN (1-257): 3.46e-130: 370: 78.21
+	Hs
		1043514 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCNL1_HUMAN (1-259): 3.35e-134: 380: 100.00
+	Hs
		1043412 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCNL2_HUMAN (1-257): 3.46e-130: 370: 78.21
+	Ce
		1088891 CUL3_CAEEL (4-768): 0: 792: 48.08		DCN1_CAEEL (1-251): 8.74e-107: 312: 36.73
+	Hs
		1041145 CUL1_HUMAN (18-768): 0: 707: 30.57		DCNL1_HUMAN (1-259): 3.35e-134: 380: 100.00
+	Hs
		1041051 CUL1_HUMAN (18-768): 0: 707: 30.57		DCNL2_HUMAN (1-257): 3.46e-130: 370: 78.21
+	Hs
		1043133 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCNL4_HUMAN (42-250): 9.75e-90: 269: 31.10
+	Hs
		1043091 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCNL3_HUMAN (54-250): 7.87e-85: 257: 41.58
+	Hs
		1043486 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCNL4_HUMAN (42-250): 9.75e-90: 269: 31.10
+	Hs
		1043197 CUL4A_HUMAN (10-768): 0: 791: 38.32		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Hs
		1043445 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCNL3_HUMAN (54-250): 7.87e-85: 257: 41.58
+	Hs
		1043549 CUL4B_HUMAN (5-768): 0: 779: 36.77		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Dm
		1124377 Q5BI50_DROME (5-768): 0: 764: 37.45		DCNL3_DROME (37-250): 4.91e-79: 243: 35.95
+	Hs
		1041123 CUL1_HUMAN (18-768): 0: 707: 30.57		DCNL4_HUMAN (42-250): 9.75e-90: 269: 31.10
+	Hs
		1041081 CUL1_HUMAN (18-768): 0: 707: 30.57		DCNL3_HUMAN (54-250): 7.87e-85: 257: 41.58