HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLHL5 (Q96PQ7)
Kelch-like protein 5
Gene: KLHL5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	31652307, 34878901, 35563538, 21145461, 21988832, 34591642, 30190310
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 755
+	Hs
		1042624 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL1_HUMAN (47-754): 0: 603: 62.70
+	Hs
		1042489 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL4_HUMAN (45-755): 0: 589: 63.13
+	Hs
		1041718 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH26_HUMAN (197-755): 0: 543: 30.02
+	Hs
		1042167 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL6_HUMAN (161-754): 0: 538: 26.35
+	Hs
		1041852 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH17_HUMAN (140-755): 4.75e-165: 492: 39.17
+	Rn
		78189 CUL3_RAT (1-768): 0: 951: 99.61		KLH17_RAT (143-755): 6.72e-165: 492: 39.65
+	Hs
		1042727 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH13_HUMAN (124-753): 8.75e-164: 489: 29.91
+	Hs
		299515 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH18_HUMAN (186-755): 1.07e-161: 481: 39.37
+	Hs
		1042722 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL9_HUMAN (174-753): 9.88e-160: 478: 30.74
+	Hs
		1042674 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH28_HUMAN (202-753): 3.38e-155: 464: 38.43
+	Hs
		1041986 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL7_HUMAN (210-753): 8.03e-81: 271: 29.66
+	Hs
		1041712 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH12_HUMAN (259-656): 3.99e-53: 195: 24.37
+	Hs
		1041547 CUL3_HUMAN (1-768): 0: 951: 100.00		KEAP1_HUMAN (559-753): 2.52e-48: 182: 37.19
+	Hs
		1042027 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH36_HUMAN (609-754): 3.72e-28: 122: 28.86
+	Hs
		1042508 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH25_HUMAN (592-755): 7.58e-21: 99.2: 25.29
+	Hs
		152489 CUL3_HUMAN (1-768): 0: 951: 100.00		ENC1_HUMAN (596-755): 2.86e-20: 97.5: 24.85
+	Hs
		307170 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL2_HUMAN (657-754): 2.84e-16: 84.9: 27.55
+	Hs
		1042720 CUL3_HUMAN (1-768): 0: 951: 100.00		KLHL8_HUMAN (447-559): 8.48e-16: 83.4: 35.40
+	Hs
		1041807 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH10_HUMAN (347-581): 1.19e-14: 79.5: 23.11
+	Hs
		1041853 CUL3_HUMAN (1-768): 0: 951: 100.00		KLH24_HUMAN (377-562): 6.64e-10: 64.5: 15.51